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The Alzheimer's disease beta-secretase enzyme, BACE1.

Cole SL, Vassar R.

Mol Neurodegener. 2007 Nov 15;2:22.PMID: 18005427 [PubMed - in process]Related articlesFree article

BACE1 structure and function in health and Alzheimer's disease.

Cole SL, Vassar R.

Curr Alzheimer Res. 2008 Apr;5(2):100-20. Review.PMID: 18393796 [PubMed - indexed for MEDLINE]Related articles

The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.

Cole SL, Vassar R.

Curr Genomics. 2007 Dec;8(8):509-30.PMID: 19415126 [PubMed - in process]Related articlesFree article

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

J Neurosci. 2007 Apr 4;27(14):3639-49.PMID: 17409228 [PubMed - indexed for MEDLINE]Related articlesFree article

Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1.

Cole SL, Vassar R.

Neurobiol Aging. 2009 Oct;30(10):1535-44. Epub 2008 Mar 4. Review.PMID: 18289733 [PubMed - indexed for MEDLINE]Related articles

The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.

Cole SL, Vassar R.

J Biol Chem. 2008 Oct 31;283(44):29621-5. Epub 2008 Jul 23. Review.PMID: 18650431 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease.

Hampel H, Shen Y.

Scand J Clin Lab Invest. 2009;69(1):8-12. Review.PMID: 18609117 [PubMed - indexed for MEDLINE]Related articles

Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Kimura R, Devi L, Ohno M.

J Neurochem. 2010 Jan 20. [Epub ahead of print]PMID: 20089133 [PubMed - as supplied by publisher]Related articles

Function, regulation and therapeutic properties of beta-secretase (BACE1).

Willem M, Lammich S, Haass C.

Semin Cell Dev Biol. 2009 Apr;20(2):175-82. Epub 2009 Jan 20. Review.PMID: 19429494 [PubMed - indexed for MEDLINE]Related articles

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.PMID: 18156464 [PubMed - indexed for MEDLINE]Related articlesFree article

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.

J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. Epub 2008 May 22.PMID: 18499745 [PubMed - indexed for MEDLINE]Related articlesFree article

BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.

Kobayashi D, Zeller M, Cole T, Buttini M, McConlogue L, Sinha S, Freedman S, Morris RG, Chen KS.

Neurobiol Aging. 2008 Jun;29(6):861-73. Epub 2007 Feb 28.PMID: 17331621 [PubMed - indexed for MEDLINE]Related articles

Human beta-secretase and Alzheimer's disease.

Citron M.

Expert Opin Ther Targets. 2001 Jun;5(3):341-348.PMID: 12540269 [PubMed - as supplied by publisher]Related articles

Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease.

Stockley JH, O'Neill C.

Cell Mol Life Sci. 2008 Oct;65(20):3265-89. Review.PMID: 18695942 [PubMed - indexed for MEDLINE]Related articles

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6415-20. Epub 2008 Apr 23.PMID: 18434550 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease.

Chen L, Na R, Gu M, Richardson A, Ran Q.

J Neurochem. 2008 Oct;107(1):197-207. Epub 2008 Aug 2.PMID: 18680556 [PubMed - indexed for MEDLINE]Related articlesFree article

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.

Vassar R, Kovacs DM, Yan R, Wong PC.

J Neurosci. 2009 Oct 14;29(41):12787-94. Review.PMID: 19828790 [PubMed - indexed for MEDLINE]Related articles

Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease.

Zhiyou C, Yong Y, Shanquan S, Jun Z, Liangguo H, Ling Y, Jieying L.

Neurochem Res. 2009 Jul;34(7):1226-35. Epub 2009 Jan 4.PMID: 19123057 [PubMed - indexed for MEDLINE]Related articles

Identification of beta-secretase (BACE1) substrates using quantitative proteomics.

Hemming ML, Elias JE, Gygi SP, Selkoe DJ.

PLoS One. 2009 Dec 29;4(12):e8477.PMID: 20041192 [PubMed - in process]Related articlesFree article

Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease.

Laws SM, Eckart K, Friedrich P, Kurz A, Förstl H, Riemenschneider M.

Neurobiol Aging. 2009 Apr 1. [Epub ahead of print]PMID: 19344981 [PubMed - as supplied by publisher]Related articles