PubMed

Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69.

Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC.

Diabetes. 2008 Feb;57(2):484-93. Epub 2007 Nov 14.PMID: 18003758 [PubMed - indexed for MEDLINE]Related articlesFree article

Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.

Whetzel AM, Bolick DT, Srinivasan S, Macdonald TL, Morris MA, Ley K, Hedrick CC.

Circ Res. 2006 Sep 29;99(7):731-9. Epub 2006 Sep 7.PMID: 16960101 [PubMed - indexed for MEDLINE]Related articlesFree article

Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP kinase phosphatase-3.

Whetzel AM, Bolick DT, Hedrick CC.

Am J Physiol Cell Physiol. 2009 Feb;296(2):C339-45. Epub 2008 Dec 17.PMID: 19091959 [PubMed - indexed for MEDLINE]Related articles

Suppression of diabetes mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (anti-I-Ag7) islet-derived CD4+ T-cell line.

Chosich N, Harrison LC.

Diabetologia. 1993 Aug;36(8):716-21.PMID: 8405738 [PubMed - indexed for MEDLINE]Related articles

Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation.

Jin Y, Knudsen E, Wang L, Bryceson Y, Damaj B, Gessani S, Maghazachi AA.

Blood. 2003 Jun 15;101(12):4909-15. Epub 2003 Feb 13.PMID: 12586615 [PubMed - indexed for MEDLINE]Related articlesFree article

The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice.

Hultcrantz M, Jacobson S, Hill NJ, Santamaria P, Flodström-Tullberg M.

Diabetologia. 2009 Feb;52(2):299-305. Epub 2008 Nov 25.PMID: 19031069 [PubMed - indexed for MEDLINE]Related articles

Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.

Matsuyuki H, Maeda Y, Yano K, Sugahara K, Chiba K, Kohno T, Igarashi Y.

Cell Mol Immunol. 2006 Dec;3(6):429-37.PMID: 17257496 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in adhesion markers, activation markers, and TcR in islet infiltrating vs. peripheral lymphocytes in the NOD mouse.

Goldrath AW, Barber L, Chen KE, Alters SE.

J Autoimmun. 1995 Apr;8(2):209-20.PMID: 7612149 [PubMed - indexed for MEDLINE]Related articles

Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.

Hughes JE, Srinivasan S, Lynch KR, Proia RL, Ferdek P, Hedrick CC.

Circ Res. 2008 Apr 25;102(8):950-8. Epub 2008 Mar 6.PMID: 18323526 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines.

Fieger CB, Huang MC, Van Brocklyn JR, Goetzl EJ.

FASEB J. 2005 Nov;19(13):1926-8. Epub 2005 Sep 7.PMID: 16148028 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenic and protective roles of CD45RB(low) CD4+ cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse.

Shimada A, Rohane P, Fathman CG, Charlton B.

Diabetes. 1996 Jan;45(1):71-8.PMID: 8522063 [PubMed - indexed for MEDLINE]Related articles

Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.

Augstein P, Dunger A, Heinke P, Wachlin G, Berg S, Hehmke B, Salzsieder E.

Biochem Biophys Res Commun. 2003 May 2;304(2):378-84.PMID: 12711326 [PubMed - indexed for MEDLINE]Related articles

Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes.

Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, Wenger RH, Ohta A, Sitkovsky M.

J Immunol. 2006 Oct 15;177(8):4962-5.PMID: 17015677 [PubMed - indexed for MEDLINE]Related articlesFree article

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs.

Shiow LR, Rosen DB, Brdicková N, Xu Y, An J, Lanier LL, Cyster JG, Matloubian M.

Nature. 2006 Mar 23;440(7083):540-4. Epub 2006 Mar 8.PMID: 16525420 [PubMed - indexed for MEDLINE]Related articles

Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor.

Dorsam G, Graeler MH, Seroogy C, Kong Y, Voice JK, Goetzl EJ.

J Immunol. 2003 Oct 1;171(7):3500-7.PMID: 14500646 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells.

Graeler M, Goetzl EJ.

FASEB J. 2002 Dec;16(14):1874-8.PMID: 12468451 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice.

Wang W, Huang MC, Goetzl EJ.

J Immunol. 2007 Apr 15;178(8):4885-90.PMID: 17404269 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells.

Mariño E, Villanueva J, Walters S, Liuwantara D, Mackay F, Grey ST.

Diabetes. 2009 Jul;58(7):1568-77. Epub 2009 Mar 31.PMID: 19336675 [PubMed - indexed for MEDLINE]Related articlesFree article

Administration of IL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice.

Tominaga Y, Nagata M, Yasuda H, Okamoto N, Arisawa K, Moriyama H, Miki M, Yokono K, Kasuga M.

Clin Immunol Immunopathol. 1998 Feb;86(2):209-18.PMID: 9473384 [PubMed - indexed for MEDLINE]Related articles

[Effects of pravastatin in prevention of diabetes and mechanism thereof: experiment with non-obese diabetic mice]

Zhang S, Yan X, Zhou PC, Huang C, Yang L, Li X, Lin J, Zhou ZG.

Zhonghua Yi Xue Za Zhi. 2008 Feb 26;88(8):568-72. Chinese. PMID: 18649776 [PubMed - indexed for MEDLINE]Related articles