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    Results: 1 to 20 of 798

    1.

    Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity.

    Riboulet-Chavey A, Diraison F, Siew LK, Wong FS, Rutter GA.

    Diabetes. 2008 Feb;57(2):415-23. Epub 2007 Nov 14.PMID: 18003756 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo.

    Richards SK, Parton LE, Leclerc I, Rutter GA, Smith RM.

    J Endocrinol. 2005 Nov;187(2):225-35.PMID: 16293770 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.

    Chong MM, Chen Y, Darwiche R, Dudek NL, Irawaty W, Santamaria P, Allison J, Kay TW, Thomas HE.

    J Immunol. 2004 May 1;172(9):5714-21.PMID: 15100317 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Perturbations in nuclear factor-kappaB or c-Jun N-terminal kinase pathways in pancreatic beta cells confer susceptibility to cytokine-induced cell death.

    Thomas HE, Angstetra E, Fernandes RV, Mariana L, Irawaty W, Jamieson EL, Dudek NL, Kay TW.

    Immunol Cell Biol. 2006 Feb;84(1):20-7. Epub 2005 Nov 7.PMID: 16277639 [PubMed - indexed for MEDLINE]Related articles

    5.

    Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

    McKenzie MD, Carrington EM, Kaufmann T, Strasser A, Huang DC, Kay TW, Allison J, Thomas HE.

    Diabetes. 2008 May;57(5):1284-92. Epub 2008 Feb 5.PMID: 18252892 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Increased cytokine-induced cytotoxicity of pancreatic islet cells from transgenic mice expressing the Src-like tyrosine kinase GTK.

    Annerén C, Welsh M.

    Mol Med. 2001 May;7(5):301-10.PMID: 11474576 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.

    Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, Van de Casteele M.

    J Mol Endocrinol. 2003 Apr;30(2):151-61.PMID: 12683939 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis.

    Kim WH, Lee JW, Suh YH, Lee HJ, Lee SH, Oh YK, Gao B, Jung MH.

    Cell Signal. 2007 Apr;19(4):791-805. Epub 2006 Nov 28.PMID: 17127032 [PubMed - indexed for MEDLINE]Related articles

    9.

    Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

    Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.

    Br J Pharmacol. 2007 Apr;150(8):1031-43. Epub 2007 Mar 5.PMID: 17339833 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    AMP-activated protein kinase protects against anti-epidermal growth factor receptor-Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death.

    Andersson Y, Le H, Juell S, Fodstad Ø.

    Mol Cancer Ther. 2006 Apr;5(4):1050-9.PMID: 16648577 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.

    Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M.

    Biochem Pharmacol. 2008 May 15;75(10):1981-93. Epub 2008 Feb 26.PMID: 18377870 [PubMed - indexed for MEDLINE]Related articles

    12.

    Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

    Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

    Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.

    Kim HS, Hwang JT, Yun H, Chi SG, Lee SJ, Kang I, Yoon KS, Choe WJ, Kim SS, Ha J.

    J Biol Chem. 2008 Feb 15;283(7):3731-42. Epub 2007 Dec 13.PMID: 18079115 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice.

    Hill DJ, Petrik J, Arany E, McDonald TJ, Delovitch TL.

    J Endocrinol. 1999 Apr;161(1):153-65.PMID: 10194539 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

    Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis.

    Rabinovitch A, Suarez-Pinzon WL, Sooy K, Strynadka K, Christakos S.

    Endocrinology. 2001 Aug;142(8):3649-55.PMID: 11459814 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes.

    Brodie GM, Wallberg M, Santamaria P, Wong FS, Green EA.

    Diabetes. 2008 Apr;57(4):909-17. Epub 2008 Jan 9.PMID: 18184927 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas.

    Augstein P, Bahr J, Wachlin G, Heinke P, Berg S, Salzsieder E, Harrison LC.

    J Autoimmun. 2004 Dec;23(4):301-9.PMID: 15571924 [PubMed - indexed for MEDLINE]Related articles

    19.

    Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells.

    Han X, Sun Y, Scott S, Bleich D.

    Diabetes. 2001 May;50(5):1047-55.PMID: 11334407 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death.

    Schrader J, Rennekamp W, Niebergall U, Schoppet M, Jahr H, Brendel MD, Hörsch D, Hofbauer LC.

    Diabetologia. 2007 Jun;50(6):1243-7. Epub 2007 Apr 19.PMID: 17443309 [PubMed - indexed for MEDLINE]Related articles

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