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    Results: 1 to 20 of 989

    1.

    Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

    Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

    Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet.

    Arantes VC, Reis MA, Latorraca MQ, Ferreira F, Stoppiglia LF, Carneiro EM, Boschero AC.

    Br J Nutr. 2006 Dec;96(6):1006-12.PMID: 17181874 [PubMed - indexed for MEDLINE]Related articles

    3.

    Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats.

    Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A.

    Diabetes. 1999 Mar;48(3):524-30.PMID: 10078552 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation.

    Sako Y, Grill VE.

    Endocrinology. 1990 Oct;127(4):1580-9.PMID: 1698143 [PubMed - indexed for MEDLINE]Related articles

    5.

    In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression.

    Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP.

    Diabetes. 1999 Oct;48(10):1995-2000.PMID: 10512364 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans.

    Hagman DK, Hays LB, Parazzoli SD, Poitout V.

    J Biol Chem. 2005 Sep 16;280(37):32413-8. Epub 2005 Jun 8.PMID: 15944145 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats.

    Perfetti R, Zhou J, Doyle ME, Egan JM.

    Endocrinology. 2000 Dec;141(12):4600-5.PMID: 11108273 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression.

    Steil GM, Trivedi N, Jonas JC, Hasenkamp WM, Sharma A, Bonner-Weir S, Weir GC.

    Am J Physiol Endocrinol Metab. 2001 May;280(5):E788-96.PMID: 11287362 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

    Briaud I, Kelpe CL, Johnson LM, Tran PO, Poitout V.

    Diabetes. 2002 Mar;51(3):662-8.PMID: 11872664 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

    Seufert J, Weir GC, Habener JF.

    J Clin Invest. 1998 Jun 1;101(11):2528-39.PMID: 9616224 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.

    Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K.

    Diabetes. 2003 Oct;52(10):2461-74.PMID: 14514628 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Selective induction of inducible nitric oxide synthase in pancreatic islet of rat after an intravenous glucose or intralipid challenge.

    Ekelund M, Qader SS, Jimenez-Feltstrom J, Salehi A.

    Nutrition. 2006 Jun;22(6):652-60. Epub 2006 Apr 25.PMID: 16635563 [PubMed - indexed for MEDLINE]Related articles

    13.

    IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes.

    Leibowitz G, Ferber S, Apelqvist A, Edlund H, Gross DJ, Cerasi E, Melloul D, Kaiser N.

    Diabetes. 2001 Aug;50(8):1799-806.PMID: 11473041 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

    Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

    Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Elevation of plasma fatty acids by ten-hour intralipid infusion has no effect on basal or glucose-stimulated insulin secretion in normal man.

    Amery CM, Round RA, Smith JM, Nattrass M.

    Metabolism. 2000 Apr;49(4):450-4.PMID: 10778867 [PubMed - indexed for MEDLINE]Related articles

    16.

    Insulin-sparing effects of troglitazone in rat pancreatic islets.

    Bollheimer LC, Troll S, Landauer H, Wrede CE, Schölmerich J, Buettner R.

    J Mol Endocrinol. 2003 Aug;31(1):61-9.PMID: 12914525 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.

    Mosley AL, Corbett JA, Ozcan S.

    Mol Endocrinol. 2004 Sep;18(9):2279-90. Epub 2004 May 27.PMID: 15166251 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells.

    Lottmann H, Vanselow J, Hessabi B, Walther R.

    J Mol Med. 2001 Jun;79(5-6):321-8.PMID: 11485027 [PubMed - indexed for MEDLINE]Related articles

    19.

    Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element.

    Pino MF, Ye DZ, Linning KD, Green CD, Wicksteed B, Poitout V, Olson LK.

    Mol Endocrinol. 2005 May;19(5):1343-60. Epub 2005 Jan 13.PMID: 15650027 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox.

    Yoshikawa H, Tajiri Y, Sako Y, Hashimoto T, Umeda F, Nawata H.

    Metabolism. 2001 May;50(5):613-8.PMID: 11319727 [PubMed - indexed for MEDLINE]Related articles

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