PubMed

Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.

Le Stunff C, Dechartres A, Mariot V, Lotton C, Trainor C, Miraglia Del Giudice E, Meyre D, Bieche I, Laurendeau I, Froguel P, Zelenika D, Fallin D, Lathrop M, Roméo PH, Bougnères P.

Diabetes. 2008 Feb;57(2):494-502. Epub 2007 Oct 31.PMID: 17977952 [PubMed - indexed for MEDLINE]Related articlesFree article

In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes.

Clément K, Le Stunff C, Meirhaeghe A, Dechartres A, Ferrieres J, Basdevant A, Boitard C, Amouyel P, Bougnères P.

Mol Genet Metab. 2009 Mar;96(3):129-32. Epub 2008 Dec 18.PMID: 19097921 [PubMed - indexed for MEDLINE]Related articles

A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents.

Le Stunff C, Dechartres A, Miraglia Del Giudice E, Froguel P, Bougnères P.

J Clin Endocrinol Metab. 2008 Jan;93(1):212-5. Epub 2007 Oct 30.PMID: 17971428 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity.

Johansson LE, Lindblad U, Larsson CA, Råstam L, Ridderstråle M.

Eur J Endocrinol. 2008 Nov;159(5):577-83. Epub 2008 Aug 26. Erratum in: Eur J Endocrinol. 2008 Dec;159(6):843. PMID: 18728122 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the TNF-alpha -308 G/A promoter polymorphism with insulin resistance in obesity.

Dalziel B, Gosby AK, Richman RM, Bryson JM, Caterson ID.

Obes Res. 2002 May;10(5):401-7.PMID: 12006640 [PubMed - indexed for MEDLINE]Related articles

The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss.

Shin MJ, Jang Y, Koh SJ, Chae JS, Kim OY, Lee JE, Ordovas JM, Lee JH.

Int J Obes (Lond). 2006 Dec;30(12):1702-8. Epub 2006 Apr 11.PMID: 16607383 [PubMed - indexed for MEDLINE]Related articles

The tumour necrosis factor (TNF)-alpha-308GA promoter polymorphism is related to prenatal growth and postnatal insulin resistance.

Casano-Sancho P, López-Bermejo A, Fernández-Real JM, Monrós E, Valls C, Rodríguez-González FX, Ricart W, Ibáñez L.

Clin Endocrinol (Oxf). 2006 Feb;64(2):129-35.PMID: 16430709 [PubMed - indexed for MEDLINE]Related articles

A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro.

Dos Santos C, Bougnères P, Fradin D.

Diabetes. 2009 Feb;58(2):489-92. Epub 2008 Nov 4.PMID: 18984742 [PubMed - indexed for MEDLINE]Related articlesFree article

A new variation in the promoter region, the -604 C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance.

Zavarella S, Petrone A, Zampetti S, Gueorguiev M, Spoletini M, Mein CA, Leto G, Korbonits M, Buzzetti R.

Int J Obes (Lond). 2008 Apr;32(4):663-8. Epub 2007 Dec 11.PMID: 18071345 [PubMed - indexed for MEDLINE]Related articles

Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.

Jacobsson JA, Klovins J, Kapa I, Danielsson P, Svensson V, Ridderstråle M, Gyllensten U, Marcus C, Fredriksson R, Schiöth HB.

Int J Obes (Lond). 2008 Nov;32(11):1730-5. Epub 2008 Sep 16.PMID: 18794893 [PubMed - indexed for MEDLINE]Related articles

Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults.

Gianotti TF, Sookoian S, Gemma C, Burgueño AL, González CD, Pirola CJ.

Obesity (Silver Spring). 2008 Jul;16(7):1702-7. Epub 2008 Apr 24.PMID: 18451776 [PubMed - indexed for MEDLINE]Related articles

PAI-1 gene 4G/5G polymorphism, cytokine levels and their relations with metabolic parameters in obese children.

Kinik ST, Ozbek N, Yuce M, Yazici AC, Verdi H, Ataç FB.

Thromb Haemost. 2008 Feb;99(2):352-6.PMID: 18278185 [PubMed - indexed for MEDLINE]Related articles

Body composition and -174G/C interleukin-6 promoter gene polymorphism: association with progression of insulin resistance in normal weight obese syndrome.

Di Renzo L, Bertoli A, Bigioni M, Del Gobbo V, Premrov MG, Calabrese V, Di Daniele N, De Lorenzo A.

Curr Pharm Des. 2008;14(26):2699-706.PMID: 18991689 [PubMed - indexed for MEDLINE]Related articles

Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity.

Johansson LE, Danielsson P, Norgren S, Marcus C, Ridderstråle M.

Int J Pediatr Obes. 2009;4(2):119-25.PMID: 18645733 [PubMed - indexed for MEDLINE]Related articles

Promoter polymorphisms -359T/C and -303A/G of the catalytic subunit p110beta gene of human phosphatidylinositol 3-kinase are not associated with insulin secretion or insulin sensitivity in finnish subjects.

Kossila M, Pihlajamäki J, Kärkkäinen P, Miettinen R, Kekäläinen P, Vauhkonen I, Ylä-Herttuala S, Laakso M.

Diabetes Care. 2003 Jan;26(1):179-82.PMID: 12502677 [PubMed - indexed for MEDLINE]Related articlesFree article

ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.

Böttcher Y, Körner A, Reinehr T, Enigk B, Kiess W, Stumvoll M, Kovacs P.

J Clin Endocrinol Metab. 2006 Dec;91(12):4948-52. Epub 2006 Sep 12.PMID: 16968801 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study.

Palmer ND, Goodarzi MO, Langefeld CD, Ziegler J, Norris JM, Haffner SM, Bryer-Ash M, Bergman RN, Wagenknecht LE, Taylor KD, Rotter JI, Bowden DW.

Diabetes. 2008 Apr;57(4):1093-100. Epub 2008 Feb 5.PMID: 18252897 [PubMed - indexed for MEDLINE]Related articlesFree article

The peroxisome proliferator-activated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study.

Li S, Chen W, Srinivasan SR, Boerwinkle E, Berenson GS; Bogalusa Heart Study.

Diabetes. 2003 May;52(5):1265-9.PMID: 12716762 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population.

Halsall DJ, Luan J, Saker P, Huxtable S, Farooqi IS, Keogh J, Wareham NJ, O'Rahilly S.

Int J Obes Relat Metab Disord. 2001 Apr;25(4):472-7.PMID: 11319649 [PubMed - indexed for MEDLINE]Related articles

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.

Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC.

Diabetes. 2008 Jul;57(7):1971-7. Epub 2008 Apr 21.PMID: 18426862 [PubMed - indexed for MEDLINE]Related articlesFree article