PubMed

Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study.

Doi Y, Kubo M, Ninomiya T, Yonemoto K, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y.

Diabetes. 2007 Nov;56(11):2829-33.PMID: 17965318 [PubMed - indexed for MEDLINE]Related articlesFree article

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.

Nielsen EM, Hansen L, Carstensen B, Echwald SM, Drivsholm T, Glümer C, Thorsteinsson B, Borch-Johnsen K, Hansen T, Pedersen O.

Diabetes. 2003 Feb;52(2):573-7.PMID: 12540638 [PubMed - indexed for MEDLINE]Related articlesFree article

The E23K variant in the Kir6.2 subunit of the ATP-sensitive K+ channel does not augment impaired glucose tolerance in Caribbean subjects with a family history of type 2 diabetes.

Ezenwaka C, Kalloo R, Uhlig M, Schwenk R, Eckel J.

J Endocrinol. 2005 Jun;185(3):439-44.PMID: 15930170 [PubMed - indexed for MEDLINE]Related articlesFree article

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.

Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS.

Diabetes. 2009 Aug;58(8):1869-78. Epub 2009 Jun 2.PMID: 19491206 [PubMed - indexed for MEDLINE]Related articlesFree article

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.

Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2003 Feb;52(2):568-72.PMID: 12540637 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variants in the ATP-sensitive K+ channel genes KCNJ11 (Kir6.2) and ABCC8 (SUR1) in relation to glucose intolerance: population-based studies and meta-analyses.

van Dam RM, Hoebee B, Seidell JC, Schaap MM, de Bruin TW, Feskens EJ.

Diabet Med. 2005 May;22(5):590-8.PMID: 15842514 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.

Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group.

J Clin Endocrinol Metab. 2004 Dec;89(12):6286-90.PMID: 15579791 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the E23K polymorphism in the KCNJ11 gene with gestational diabetes mellitus.

Shaat N, Ekelund M, Lernmark A, Ivarsson S, Almgren P, Berntorp K, Groop L.

Diabetologia. 2005 Dec;48(12):2544-51. Epub 2005 Nov 17.PMID: 16320083 [PubMed - indexed for MEDLINE]Related articles

The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P.

J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. Epub 2006 Apr 4.PMID: 16595597 [PubMed - indexed for MEDLINE]Related articlesFree article

An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance.

Rietveld I, Hofman A, Pols HA, van Duijn CM, Lamberts SW, Janssen JA.

Eur J Endocrinol. 2006 May;154(5):715-21.PMID: 16645019 [PubMed - indexed for MEDLINE]Related articlesFree article

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.

Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, Velho G, Froguel P.

Diabetologia. 1998 Dec;41(12):1511-5.PMID: 9867219 [PubMed - indexed for MEDLINE]Related articles

Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.

Oizumi T, Daimon M, Saitoh T, Kameda W, Yamaguchi H, Ohnuma H, Igarashi M, Eguchi H, Manaka H, Tominaga M, Kato T; Funagata Diabetes Study.

Diabetes Care. 2001 Sep;24(9):1579-83.PMID: 11522702 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.

Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D.

Diabetes. 2007 Feb;56(2):531-6.PMID: 17259403 [PubMed - indexed for MEDLINE]Related articlesFree article

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.

Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

Diabetes. 2004 May;53(5):1360-8.PMID: 15111507 [PubMed - indexed for MEDLINE]Related articlesFree article

The E23K polymorphism in Kir6.2 gene and coronary heart disease.

Xiong C, Zheng F, Wan J, Zhou X, Yin Z, Sun X.

Clin Chim Acta. 2006 May;367(1-2):93-7. Epub 2006 Feb 7.PMID: 16455067 [PubMed - indexed for MEDLINE]Related articles

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC; UK Prospective Diabetes Study (UKPDS 53).

Diabet Med. 2001 Mar;18(3):206-12. Erratum in: Diabet Med. 2003 Mar;20(3):252.. PMID: 11318841 [PubMed - indexed for MEDLINE]Related articles

Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects.

Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S.

Diabetes. 2006 Aug;55(8):2379-86.PMID: 16873704 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.

Vaxillaire M, Veslot J, Dina C, Proença C, Cauchi S, Charpentier G, Tichet J, Fumeron F, Marre M, Meyre D, Balkau B, Froguel P; DESIR Study Group.

Diabetes. 2008 Jan;57(1):244-54. Epub 2007 Oct 31.PMID: 17977958 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women.

Qi L, van Dam RM, Asselbergs FW, Hu FB.

Diabet Med. 2007 Nov;24(11):1187-91. Epub 2007 Sep 26.PMID: 17894829 [PubMed - indexed for MEDLINE]Related articles

The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish Diabetes Prevention Study.

Todorova B, Kubaszek A, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study.

J Clin Endocrinol Metab. 2004 May;89(5):2019-23.PMID: 15126514 [PubMed - indexed for MEDLINE]Related articlesFree article