PubMed

Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation.

Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, Nielsen AL, Albrechtsen A, Borch-Johnsen K, Rasmussen SS, Clausen JO, Sandbaek A, Lauritzen T, Hansen L, Jørgensen T, Pedersen O, Hansen T.

Diabetes. 2008 Jan;57(1):95-101. Epub 2007 Oct 17.PMID: 17942823 [PubMed - indexed for MEDLINE]Related articlesFree article

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.

Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, Ruokonen A, Ebrahim S, Shields B, Zeggini E, Weedon MN, Lindgren CM, Lango H, Melzer D, Ferrucci L, Paolisso G, Neville MJ, Karpe F, Palmer CN, Morris AD, Elliott P, Jarvelin MR, Smith GD, McCarthy MI, Hattersley AT, Frayling TM.

Diabetes. 2008 May;57(5):1419-26. Epub 2008 Mar 17.PMID: 18346983 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study.

Legry V, Cottel D, Ferrières J, Arveiler D, Andrieux N, Bingham A, Wagner A, Ruidavets JB, Ducimetière P, Amouyel P, Meirhaeghe A.

Metabolism. 2009 Jul;58(7):971-5.PMID: 19375760 [PubMed - indexed for MEDLINE]Related articles

FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness.

Kring SI, Holst C, Zimmermann E, Jess T, Berentzen T, Toubro S, Hansen T, Astrup A, Pedersen O, Sørensen TI.

PLoS One. 2008 Aug 13;3(8):e2958.PMID: 18698412 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome.

Barber TM, Bennett AJ, Groves CJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Hartikainen AL, Elliott P, Lindgren CM, Freathy RM, Koch K, Ouwehand WH, Karpe F, Conway GS, Wass JA, Järvelin MR, Franks S, McCarthy MI.

Diabetologia. 2008 Jul;51(7):1153-8. Epub 2008 May 14.PMID: 18478198 [PubMed - indexed for MEDLINE]Related articles

Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.

Qi L, Kang K, Zhang C, van Dam RM, Kraft P, Hunter D, Lee CH, Hu FB.

Diabetes. 2008 Nov;57(11):3145-51. Epub 2008 Jul 22.PMID: 18647953 [PubMed - indexed for MEDLINE]Related articlesFree article

The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients.

Zabena C, González-Sánchez JL, Martínez-Larrad MT, Torres-García A, Alvarez-Fernández-Represa J, Corbatón-Anchuelo A, Pérez-Barba M, Serrano-Ríos M.

Obes Surg. 2009 Jan;19(1):87-95. Epub 2008 Oct 15.PMID: 18855084 [PubMed - indexed for MEDLINE]Related articles

Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.

Chang YC, Liu PH, Lee WJ, Chang TJ, Jiang YD, Li HY, Kuo SS, Lee KC, Chuang LM.

Diabetes. 2008 Aug;57(8):2245-52. Epub 2008 May 16.PMID: 18487448 [PubMed - indexed for MEDLINE]Related articlesFree article

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen AL, Marre M, Vol S, Tammelin T, Laitinen J, Gonzalez-Izquierdo A, Blakemore AI, Elliott P, Meyre D, Balkau B, Järvelin MR, Froguel P.

J Mol Med. 2009 May;87(5):537-46. Epub 2009 Mar 3.PMID: 19255736 [PubMed - indexed for MEDLINE]Related articles

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

Grarup N, Urhammer SA, Ek J, Albrechtsen A, Glümer C, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O.

Diabetologia. 2006 Sep;49(9):2097-104. Epub 2006 Jul 25.PMID: 16865358 [PubMed - indexed for MEDLINE]Related articles

Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue.

Grunnet LG, Nilsson E, Ling C, Hansen T, Pedersen O, Groop L, Vaag A, Poulsen P.

Diabetes. 2009 Oct;58(10):2402-8. Epub 2009 Jul 8.PMID: 19587359 [PubMed - indexed for MEDLINE]Related articles

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR.

PLoS Genet. 2007 Jul;3(7):e115.PMID: 17658951 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study.

Do R, Bailey SD, Desbiens K, Belisle A, Montpetit A, Bouchard C, Pérusse L, Vohl MC, Engert JC.

Diabetes. 2008 Apr;57(4):1147-50. Epub 2008 Mar 3.PMID: 18316358 [PubMed - indexed for MEDLINE]Related articlesFree article

'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.

Müller TD, Hinney A, Scherag A, Nguyen TT, Schreiner F, Schäfer H, Hebebrand J, Roth CL, Reinehr T.

BMC Med Genet. 2008 Sep 17;9:85.PMID: 18799002 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene.

Vimaleswaran KS, Li S, Zhao JH, Luan J, Bingham SA, Khaw KT, Ekelund U, Wareham NJ, Loos RJ.

Am J Clin Nutr. 2009 Aug;90(2):425-8. Epub 2009 Jun 24.PMID: 19553294 [PubMed - indexed for MEDLINE]Related articles

Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults.

Jonsson A, Renström F, Lyssenko V, Brito EC, Isomaa B, Berglund G, Nilsson PM, Groop L, Franks PW.

Diabetologia. 2009 Jul;52(7):1334-8. Epub 2009 Apr 17.PMID: 19373445 [PubMed - indexed for MEDLINE]Related articles

FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

Yajnik CS, Janipalli CS, Bhaskar S, Kulkarni SR, Freathy RM, Prakash S, Mani KR, Weedon MN, Kale SD, Deshpande J, Krishnaveni GV, Veena SR, Fall CH, McCarthy MI, Frayling TM, Hattersley AT, Chandak GR.

Diabetologia. 2009 Feb;52(2):247-52. Epub 2008 Nov 13.PMID: 19005641 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population.

Li H, Wu Y, Loos RJ, Hu FB, Liu Y, Wang J, Yu Z, Lin X.

Diabetes. 2008 Jan;57(1):264-8. Epub 2007 Oct 24.PMID: 17959933 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in the FTO gene are associated with severe obesity in the Japanese.

Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Masuzaki H, Yoneda M, Nakajima A, Miyazaki S, Tokunaga K, Kawamoto M, Funahashi T, Hamaguchi K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Nakao K, Sakata T, Matsuzawa Y, Tanaka K, Kamatani N, Nakamura Y.

J Hum Genet. 2008;53(6):546-53. Epub 2008 Apr 1.PMID: 18379722 [PubMed - indexed for MEDLINE]Related articlesFree article

The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.

Grarup N, Andreasen CH, Andersen MK, Albrechtsen A, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O.

J Clin Endocrinol Metab. 2008 Jun;93(6):2294-9. Epub 2008 Mar 25.PMID: 18364377 [PubMed - indexed for MEDLINE]Related articlesFree article