PubMed

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.

McDuffie M, Maybee NA, Keller SR, Stevens BK, Garmey JC, Morris MA, Kropf E, Rival C, Ma K, Carter JD, Tersey SA, Nunemaker CS, Nadler JL.

Diabetes. 2008 Jan;57(1):199-208. Epub 2007 Oct 16.PMID: 17940120 [PubMed - indexed for MEDLINE]Related articlesFree article

An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data.

Weisberg SP, Leibel RL.

Diabetes. 2008 Jan;57(1):1-2. No abstract available. PMID: 18165353 [PubMed - indexed for MEDLINE]Related articlesFree article

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.

Ivakine EA, Mortin-Toth SM, Gulban OM, Valova A, Canty A, Scott C, Danska JS.

Diabetes. 2006 Dec;55(12):3611-9.PMID: 17130511 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.

Grattan M, Mi QS, Meagher C, Delovitch TL.

Diabetes. 2002 Jan;51(1):215-23.PMID: 11756344 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.

Ivakine EA, Gulban OM, Mortin-Toth SM, Wankiewicz E, Scott C, Spurrell D, Canty A, Danska JS.

J Immunol. 2006 Mar 1;176(5):2976-90.PMID: 16493056 [PubMed - indexed for MEDLINE]Related articlesFree article

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.

Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ, Lord CJ, Wilusz MB, Peterson LB, Wicker LS, Todd JA.

Genome Res. 2000 Apr;10(4):446-53.PMID: 10779485 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes.

Gonzalez C, Cuvellier S, Hue-Beauvais C, Lévi-Strauss M.

Diabetologia. 2003 Sep;46(9):1291-5. Epub 2003 Jul 15.PMID: 12879252 [PubMed - indexed for MEDLINE]Related articles

Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes.

Rosmalen JG, Martin T, Dobbs C, Voerman JS, Drexhage HA, Haskins K, Leenen PJ.

Lab Invest. 2000 Jan;80(1):23-30.PMID: 10652999 [PubMed - indexed for MEDLINE]Related articles

Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice.

Kim S, Kim HS, Chung KW, Oh SH, Yun JW, Im SH, Lee MK, Kim KW, Lee MS.

Diabetes. 2007 Oct;56(10):2561-8. Epub 2007 Jul 9.PMID: 17620422 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissimilar background genes control susceptibility to autoimmune disease in the context of different MHC haplotypes: NOD.H-2(s) congenic mice are relatively resistant to both experimental autoimmune encephalomyelitis and type I diabetes.

Greve B, Reddy J, Waldner HP, Sobel RA, Kuchroo VK.

Eur J Immunol. 2004 Jul;34(7):1828-38.PMID: 15214031 [PubMed - indexed for MEDLINE]Related articles

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

Serreze DV, Chapman HD, Varnum DS, Hanson MS, Reifsnyder PC, Richard SD, Fleming SA, Leiter EH, Shultz LD.

J Exp Med. 1996 Nov 1;184(5):2049-53.PMID: 8920894 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.

Litherland SA, Grebe KM, Belkin NS, Paek E, Elf J, Atkinson M, Morel L, Clare-Salzler MJ, McDuffie M.

J Immunol. 2005 Oct 1;175(7):4561-5.PMID: 16177100 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.

Bleich D, Chen S, Zipser B, Sun D, Funk CD, Nadler JL.

J Clin Invest. 1999 May 15;103(10):1431-6.PMID: 10330425 [PubMed - indexed for MEDLINE]Related articlesFree article

Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice.

Simpson PB, Mistry MS, Maki RA, Yang W, Schwarz DA, Johnson EB, Lio FM, Alleva DG.

J Immunol. 2003 Oct 1;171(7):3333-7.PMID: 14500624 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability.

Prasad KM, Thimmalapura PR, Woode EA, Nadler JL.

Biochem Biophys Res Commun. 2003 Aug 29;308(3):427-32.PMID: 12914766 [PubMed - indexed for MEDLINE]Related articles

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice.

Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum JL, Nadler JL, Funk CD, Ley K.

Circulation. 2004 Oct 5;110(14):2024-31. Epub 2004 Sep 27. Erratum in: Circulation. 2004 Nov 9;110(19):3156. PMID: 15451785 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular and molecular mechanisms of the selective regulation of IL-12 production by 12/15-lipoxygenase.

Middleton MK, Rubinstein T, Puré E.

J Immunol. 2006 Jan 1;176(1):265-74.PMID: 16365418 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.

Wen Y, Gu J, Vandenhoff GE, Liu X, Nadler JL.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1933-8. Epub 2008 Feb 22.PMID: 18296557 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC.

Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.PMID: 19336673 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic deficiency of Itgb2 or ItgaL prevents autoimmune diabetes through distinctly different mechanisms in NOD/LtJ mice.

Glawe JD, Patrick DR, Huang M, Sharp CD, Barlow SC, Kevil CG.

Diabetes. 2009 Jun;58(6):1292-301. Epub 2009 Feb 17.PMID: 19223596 [PubMed - indexed for MEDLINE]Related articlesFree article