PubMed

SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis.

Tew SR, Clegg PD, Brew CJ, Redmond CM, Hardingham TE.

Arthritis Res Ther. 2007;9(5):R107.PMID: 17935617 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.

Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE.

Osteoarthritis Cartilage. 2005 Jan;13(1):80-9.PMID: 15639641 [PubMed - indexed for MEDLINE]Related articles

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

Li Y, Tew SR, Russell AM, Gonzalez KR, Hardingham TE, Hawkins RE.

Tissue Eng. 2004 Mar-Apr;10(3-4):575-84.PMID: 15165474 [PubMed - indexed for MEDLINE]Related articles

Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis.

Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F.

Arthritis Rheum. 2007 Nov;56(11):3693-705.PMID: 17968906 [PubMed - indexed for MEDLINE]Related articlesFree article

SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription.

Tew SR, Pothacharoen P, Katopodi T, Hardingham TE.

Biochem J. 2008 Sep 1;414(2):231-6.PMID: 18433381 [PubMed - indexed for MEDLINE]Related articlesFree article

SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes.

Aigner T, Gebhard PM, Schmid E, Bau B, Harley V, Pöschl E.

Matrix Biol. 2003 Jun;22(4):363-72.PMID: 12935820 [PubMed - indexed for MEDLINE]Related articles

SOX9-dependent and -independent transcriptional regulation of human cartilage link protein.

Kou I, Ikegawa S.

J Biol Chem. 2004 Dec 3;279(49):50942-8. Epub 2004 Sep 28.PMID: 15456769 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2.

Finger F, Schörle C, Zien A, Gebhard P, Goldring MB, Aigner T.

Arthritis Rheum. 2003 Dec;48(12):3395-403.PMID: 14673991 [PubMed - indexed for MEDLINE]Related articlesFree article

Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9.

Cucchiarini M, Thurn T, Weimer A, Kohn D, Terwilliger EF, Madry H.

Arthritis Rheum. 2007 Jan;56(1):158-67.PMID: 17195218 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype.

Yagi R, McBurney D, Laverty D, Weiner S, Horton WE Jr.

J Orthop Res. 2005 Sep;23(5):1128-38.PMID: 15936918 [PubMed - indexed for MEDLINE]Related articles

Control of human articular chondrocyte differentiation by reduced oxygen tension.

Murphy CL, Polak JM.

J Cell Physiol. 2004 Jun;199(3):451-9.PMID: 15095292 [PubMed - indexed for MEDLINE]Related articles

Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation.

Dehne T, Karlsson C, Ringe J, Sittinger M, Lindahl A.

Arthritis Res Ther. 2009;11(5):R133. Epub 2009 Sep 2.PMID: 19723327 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential use of Sox9 gene therapy for intervertebral degenerative disc disease.

Paul R, Haydon RC, Cheng H, Ishikawa A, Nenadovich N, Jiang W, Zhou L, Breyer B, Feng T, Gupta P, He TC, Phillips FM.

Spine (Phila Pa 1976). 2003 Apr 15;28(8):755-63.PMID: 12698117 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor 2alpha is essential for hypoxic induction of the human articular chondrocyte phenotype.

Lafont JE, Talma S, Murphy CL.

Arthritis Rheum. 2007 Oct;56(10):3297-306.PMID: 17907154 [PubMed - indexed for MEDLINE]Related articlesFree article

Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis.

Quintavalla J, Kumar C, Daouti S, Slosberg E, Uziel-Fusi S.

J Cell Physiol. 2005 Aug;204(2):560-6.PMID: 15799031 [PubMed - indexed for MEDLINE]Related articles

Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissection.

Fukui N, Ikeda Y, Ohnuki T, Tanaka N, Hikita A, Mitomi H, Mori T, Juji T, Katsuragawa Y, Yamamoto S, Sawabe M, Yamane S, Suzuki R, Sandell LJ, Ochi T.

Arthritis Rheum. 2008 Jan;58(1):154-63.PMID: 18163492 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.

Lafont JE, Talma S, Hopfgarten C, Murphy CL.

J Biol Chem. 2008 Feb 22;283(8):4778-86. Epub 2007 Dec 12.PMID: 18077449 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes.

Saas J, Lindauer K, Bau B, Takigawa M, Aigner T.

Osteoarthritis Cartilage. 2004 Nov;12(11):924-34.PMID: 15501409 [PubMed - indexed for MEDLINE]Related articles

Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.

Olivotto E, Borzi RM, Vitellozzi R, Pagani S, Facchini A, Battistelli M, Penzo M, Li X, Flamigni F, Li J, Falcieri E, Facchini A, Marcu KB.

Arthritis Rheum. 2008 Jan;58(1):227-39. Erratum in: Arthritis Rheum. 2008 Mar;58(3):887. PMID: 18163512 [PubMed - indexed for MEDLINE]Related articlesFree article

Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.

Daouti S, Latario B, Nagulapalli S, Buxton F, Uziel-Fusi S, Chirn GW, Bodian D, Song C, Labow M, Lotz M, Quintavalla J, Kumar C.

Osteoarthritis Cartilage. 2005 Jun;13(6):508-18.PMID: 15922185 [PubMed - indexed for MEDLINE]Related articles