PubMed

Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed mice.

Lamont BJ, Drucker DJ.

Diabetes. 2008 Jan;57(1):190-8. Epub 2007 Oct 10.PMID: 17928394 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice.

Liu X, Harada N, Yamane S, Kitajima L, Uchida S, Hamasaki A, Mukai E, Toyoda K, Yamada C, Yamada Y, Seino Y, Inagaki N.

Life Sci. 2009 Jun 19;84(25-26):876-81. Epub 2009 Apr 7.PMID: 19358859 [PubMed - indexed for MEDLINE]Related articles

Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes.

Herman GA, Bergman A, Stevens C, Kotey P, Yi B, Zhao P, Dietrich B, Golor G, Schrodter A, Keymeulen B, Lasseter KC, Kipnes MS, Snyder K, Hilliard D, Tanen M, Cilissen C, De Smet M, de Lepeleire I, Van Dyck K, Wang AQ, Zeng W, Davies MJ, Tanaka W, Holst JJ, Deacon CF, Gottesdiener KM, Wagner JA.

J Clin Endocrinol Metab. 2006 Nov;91(11):4612-9. Epub 2006 Aug 15.PMID: 16912128 [PubMed - indexed for MEDLINE]Related articlesFree article

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article

Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice.

Flock G, Baggio LL, Longuet C, Drucker DJ.

Diabetes. 2007 Dec;56(12):3006-13. Epub 2007 Aug 23.PMID: 17717280 [PubMed - indexed for MEDLINE]Related articlesFree article

Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice.

Irwin N, Hunter K, Frizzell N, Flatt PR.

Regul Pept. 2009 Feb 25;153(1-3):70-6. Epub 2008 Dec 3.PMID: 19073224 [PubMed - indexed for MEDLINE]Related articles

GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.

McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1746-55. Epub 2007 Sep 11.PMID: 17848629 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors.

Neumiller JJ.

J Am Pharm Assoc (2003). 2009 Sep-Oct;49 Suppl 1:S16-29. Review.PMID: 19801361 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.

Duez H, Smith AC, Xiao C, Giacca A, Szeto L, Drucker DJ, Lewis GF.

Endocrinology. 2009 Jan;150(1):56-62. Epub 2008 Sep 18.PMID: 18801896 [PubMed - indexed for MEDLINE]Related articles

Comparison of the subchronic antidiabetic effects of DPP IV-resistant GIP and GLP-1 analogues in obese diabetic (ob/ob) mice.

Irwin N, McClean PL, Flatt PR.

J Pept Sci. 2007 Jun;13(6):400-5.PMID: 17486662 [PubMed - indexed for MEDLINE]Related articles

Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1.

Green BD, Irwin N, Duffy NA, Gault VA, O'harte FP, Flatt PR.

Eur J Pharmacol. 2006 Oct 10;547(1-3):192-9. Epub 2006 Jul 27.PMID: 16945366 [PubMed - indexed for MEDLINE]Related articles

Incretin and islet hormonal responses to fat and protein ingestion in healthy men.

Carr RD, Larsen MO, Winzell MS, Jelic K, Lindgren O, Deacon CF, Ahrén B.

Am J Physiol Endocrinol Metab. 2008 Oct;295(4):E779-84. Epub 2008 Jul 8.PMID: 18612044 [PubMed - indexed for MEDLINE]Related articlesFree article

Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs.

Deacon CF, Wamberg S, Bie P, Hughes TE, Holst JJ.

J Endocrinol. 2002 Feb;172(2):355-62.PMID: 11834453 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-cell failure in diabetes and preservation by clinical treatment.

Wajchenberg BL.

Endocr Rev. 2007 Apr;28(2):187-218. Epub 2007 Mar 12. Review.PMID: 17353295 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic mice.

Kim SJ, Nian C, Doudet DJ, McIntosh CH.

Diabetes. 2008 May;57(5):1331-9. Epub 2008 Feb 25.PMID: 18299314 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1.

Duffy NA, Green BD, Irwin N, Gault VA, McKillop AM, O'Harte FP, Flatt PR.

Eur J Pharmacol. 2007 Jul 30;568(1-3):278-86. Epub 2007 May 13.PMID: 17573070 [PubMed - indexed for MEDLINE]Related articles

Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

Gault VA, McClean PL, Cassidy RS, Irwin N, Flatt PR.

Diabetologia. 2007 Aug;50(8):1752-62. Epub 2007 Jun 9.PMID: 17558485 [PubMed - indexed for MEDLINE]Related articles

A comparison of the cellular and biological properties of DPP-IV-resistant N-glucitol analogues of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide.

Green BD, Gault VA, O'Harte FP, Flatt PR.

Diabetes Obes Metab. 2005 Sep;7(5):595-604.PMID: 16050953 [PubMed - indexed for MEDLINE]Related articles

GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.

Hansotia T, Drucker DJ.

Regul Pept. 2005 Jun 15;128(2):125-34. Review.PMID: 15780432 [PubMed - indexed for MEDLINE]Related articles

Effects of sub-chronic exposure to naturally occurring N-terminally truncated metabolites of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), GIP(3-42) and GLP-1(9-36)amide, on insulin secretion and glucose homeostasis in ob/ob mice.

Parker JC, Lavery KS, Irwin N, Green BD, Greer B, Harriott P, O'Harte FP, Gault VA, Flatt PR.

J Endocrinol. 2006 Oct;191(1):93-100.PMID: 17065392 [PubMed - indexed for MEDLINE]Related articlesFree article