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    Results: 1 to 20 of 150

    1.

    Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

    Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH, Choi HS.

    Diabetes. 2008 Feb;57(2):306-14. Epub 2007 Oct 1.PMID: 17909097 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.

    Chanda D, Kim SJ, Lee IK, Shong M, Choi HS.

    Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E368-79. Epub 2008 May 27.PMID: 18505831 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression.

    Viana AY, Sakoda H, Anai M, Fujishiro M, Ono H, Kushiyama A, Fukushima Y, Sato Y, Oshida Y, Uchijima Y, Kurihara H, Asano T.

    Diabetes Res Clin Pract. 2006 Aug;73(2):135-42. Epub 2006 Feb 28.PMID: 16503364 [PubMed - indexed for MEDLINE]Related articles

    4.

    Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.

    Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, Chiang JY, Choi HS.

    J Biol Chem. 2009 Oct 16;284(42):28510-21. Epub 2009 Aug 31.PMID: 19720831 [PubMed - in process]Related articles

    5.

    Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase.

    Berasi SP, Huard C, Li D, Shih HH, Sun Y, Zhong W, Paulsen JE, Brown EL, Gimeno RE, Martinez RV.

    J Biol Chem. 2006 Sep 15;281(37):27167-77. Epub 2006 Jul 18.PMID: 16849326 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Role of AMP-activated protein kinase in mechanism of metformin action.

    Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

    J Clin Invest. 2001 Oct;108(8):1167-74.PMID: 11602624 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells.

    Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA.

    J Biol Chem. 2004 Nov 12;279(46):47898-905. Epub 2004 Sep 14.PMID: 15371448 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

    Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

    J Biol Chem. 2004 Oct 15;279(42):43940-51. Epub 2004 Jul 19.PMID: 15265871 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation.

    Jacobs RL, Lingrell S, Dyck JR, Vance DE.

    J Biol Chem. 2007 Feb 16;282(7):4516-23. Epub 2006 Dec 19.PMID: 17179149 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion.

    Leclerc I, Woltersdorf WW, da Silva Xavier G, Rowe RL, Cross SE, Korbutt GS, Rajotte RV, Smith R, Rutter GA.

    Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31. Epub 2004 Feb 10.PMID: 14871885 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

    Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.

    Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.PMID: 16308421 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase.

    Davis BJ, Xie Z, Viollet B, Zou MH.

    Diabetes. 2006 Feb;55(2):496-505.PMID: 16443786 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver.

    Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A, Thorens B, Vaulont S, Viollet B.

    Diabetes. 2005 May;54(5):1331-9.PMID: 15855317 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner.

    Chanda D, Lee CH, Kim YH, Noh JR, Kim DK, Park JH, Hwang JH, Lee MR, Jeong KH, Lee IK, Kweon GR, Shong M, Oh GT, Chiang JY, Choi HS.

    Hepatology. 2009 Sep;50(3):880-92.PMID: 19593819 [PubMed - indexed for MEDLINE]Related articles

    15.

    Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells.

    Hattori Y, Suzuki K, Hattori S, Kasai K.

    Hypertension. 2006 Jun;47(6):1183-8. Epub 2006 Apr 24.PMID: 16636195 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase.

    Rattan R, Giri S, Singh AK, Singh I.

    J Biol Chem. 2005 Nov 25;280(47):39582-93. Epub 2005 Sep 21.PMID: 16176927 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    A physiological role of AMP-activated protein kinase in phenobarbital-mediated constitutive androstane receptor activation and CYP2B induction.

    Shindo S, Numazawa S, Yoshida T.

    Biochem J. 2007 Feb 1;401(3):735-41.PMID: 17032173 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms.

    Saeedi R, Parsons HL, Wambolt RB, Paulson K, Sharma V, Dyck JR, Brownsey RW, Allard MF.

    Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2497-506. Epub 2008 Mar 28.PMID: 18375721 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver.

    Rencurel F, Foretz M, Kaufmann MR, Stroka D, Looser R, Leclerc I, da Silva Xavier G, Rutter GA, Viollet B, Meyer UA.

    Mol Pharmacol. 2006 Dec;70(6):1925-34. Epub 2006 Sep 20.PMID: 16988011 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

    Kukidome D, Nishikawa T, Sonoda K, Imoto K, Fujisawa K, Yano M, Motoshima H, Taguchi T, Matsumura T, Araki E.

    Diabetes. 2006 Jan;55(1):120-7.PMID: 16380484 [PubMed - indexed for MEDLINE]Related articlesFree article

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