PubMed

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers.

Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG.

Mol Neurodegener. 2007 Sep 26;2:18.PMID: 17897471 [PubMed - in process]Related articlesFree article

Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation.

Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C.

J Biol Chem. 2010 Feb 26;285(9):6071-9. Epub 2009 Dec 15.PMID: 20018889 [PubMed - in process]Related articles

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction.

Tomic JL, Pensalfini A, Head E, Glabe CG.

Neurobiol Dis. 2009 Sep;35(3):352-8. Epub 2009 Jun 10.PMID: 19523517 [PubMed - indexed for MEDLINE]Related articles

A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain.

Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E.

Acta Neuropathol. 2009 Oct;118(4):505-17. Epub 2009 Apr 10.PMID: 19360426 [PubMed - indexed for MEDLINE]Related articlesFree article

Structural classification of toxic amyloid oligomers.

Glabe CG.

J Biol Chem. 2008 Oct 31;283(44):29639-43. Epub 2008 Aug 22. Review.PMID: 18723507 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformation-dependent anti-amyloid oligomer antibodies.

Kayed R, Glabe CG.

Methods Enzymol. 2006;413:326-44.PMID: 17046404 [PubMed - indexed for MEDLINE]Related articles

Humoral immune response to fibrillar beta-amyloid peptide.

Miller DL, Currie JR, Mehta PD, Potempska A, Hwang YW, Wegiel J.

Biochemistry. 2003 Oct 14;42(40):11682-92.PMID: 14529278 [PubMed - indexed for MEDLINE]Related articles

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin.

Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J.

Mol Neurodegener. 2008 Oct 21;3:16.PMID: 18939994 [PubMed - in process]Related articlesFree article

Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer.

Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C.

J Biol Chem. 2009 Feb 13;284(7):4230-7. Epub 2008 Dec 18.PMID: 19098006 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.

Meredith SC.

Ann N Y Acad Sci. 2005 Dec;1066:181-221. Review.PMID: 16533927 [PubMed - indexed for MEDLINE]Related articles

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.

Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG.

Science. 2003 Apr 18;300(5618):486-9.PMID: 12702875 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide.

Moretto N, Bolchi A, Rivetti C, Imbimbo BP, Villetti G, Pietrini V, Polonelli L, Del Signore S, Smith KM, Ferrante RJ, Ottonello S.

J Biol Chem. 2007 Apr 13;282(15):11436-45. Epub 2007 Jan 31.PMID: 17267402 [PubMed - indexed for MEDLINE]Related articlesFree article

Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers.

Wang XP, Zhang JH, Wang YJ, Feng Y, Zhang X, Sun XX, Li JL, Du XT, Lambert MP, Yang SG, Zhao M, Klein WL, Liu RT.

FEBS Lett. 2009 Feb 4;583(3):579-84. Epub 2009 Jan 20.PMID: 19162022 [PubMed - indexed for MEDLINE]Related articles

Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers.

Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J.

J Clin Invest. 2006 Feb;116(2):378-85.PMID: 16453022 [PubMed - indexed for MEDLINE]Related articlesFree article

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.

Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.

Diabetes. 2007 May;56(5):1324-32. Epub 2007 Mar 12.PMID: 17353506 [PubMed - indexed for MEDLINE]Related articlesFree article

Amyloid oligomers: formation and toxicity of Abeta oligomers.

Sakono M, Zako T.

FEBS J. 2010 Mar;277(6):1348-58. Epub 2010 Feb 9.PMID: 20148964 [PubMed - in process]Related articles

Direct in vivo intracellular selection of conformation-sensitive antibody domains targeting Alzheimer's amyloid-beta oligomers.

Meli G, Visintin M, Cannistraci I, Cattaneo A.

J Mol Biol. 2009 Apr 3;387(3):584-606. Epub 2009 Feb 4.PMID: 19361429 [PubMed - indexed for MEDLINE]Related articles

Conformational Abs recognizing a generic amyloid fibril epitope.

O'Nuallain B, Wetzel R.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1485-90. Epub 2002 Jan 29.PMID: 11818542 [PubMed - indexed for MEDLINE]Related articlesFree article

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases.

Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG.

J Biol Chem. 2004 Nov 5;279(45):46363-6. Epub 2004 Sep 21.PMID: 15385542 [PubMed - indexed for MEDLINE]Related articlesFree article

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils.

Habicht G, Haupt C, Friedrich RP, Hortschansky P, Sachse C, Meinhardt J, Wieligmann K, Gellermann GP, Brodhun M, Götz J, Halbhuber KJ, Röcken C, Horn U, Fändrich M.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19232-7. Epub 2007 Nov 27.PMID: 18042730 [PubMed - indexed for MEDLINE]Related articlesFree article