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    Results: 1 to 20 of 939

    1.

    Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

    Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

    Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Prolonged elevation of plasma free fatty acids desensitizes the insulin secretory response to glucose in vivo in rats.

    Mason TM, Goh T, Tchipashvili V, Sandhu H, Gupta N, Lewis GF, Giacca A.

    Diabetes. 1999 Mar;48(3):524-30.PMID: 10078552 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

    Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A.

    Diabetes. 2007 Nov;56(11):2722-31. Epub 2007 Aug 6.PMID: 17682092 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

    Piro S, Anello M, Di Pietro C, Lizzio MN, Patanè G, Rabuazzo AM, Vigneri R, Purrello M, Purrello F.

    Metabolism. 2002 Oct;51(10):1340-7.PMID: 12370856 [PubMed - indexed for MEDLINE]Related articles

    5.

    N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.

    Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG.

    Am J Physiol Endocrinol Metab. 2003 Oct;285(4):E744-53. Epub 2003 Jun 10.PMID: 12799318 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.

    Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K.

    Diabetes. 2003 Oct;52(10):2461-74.PMID: 14514628 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Effects of different free fatty acids on insulin resistance in rats.

    Han P, Zhang YY, Lu Y, He B, Zhang W, Xia F.

    Hepatobiliary Pancreat Dis Int. 2008 Feb;7(1):91-6.PMID: 18234646 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

    Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ.

    J Clin Invest. 1998 Mar 1;101(5):1094-101.PMID: 9486980 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion.

    Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S.

    Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E560-7. Epub 2003 Nov 18.PMID: 14625208 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets.

    Ayvaz G, Balos Törüner F, Karakoç A, Yetkin I, Cakir N, Arslan M.

    Diabetes Metab. 2002 Dec;28(6 Pt 2):3S7-12; discussion 3S108-12.PMID: 12688627 [PubMed - indexed for MEDLINE]Related articles

    11.

    Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

    Zhou YP, Grill VE.

    J Clin Invest. 1994 Feb;93(2):870-6.PMID: 8113418 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Effects of fatty acid regulation on visfatin gene expression in adipocytes.

    Wen Y, Wang HW, Wu J, Lu HL, Hu XF, Cianflone K.

    Chin Med J (Engl). 2006 Oct 20;119(20):1701-8.PMID: 17097017 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

    Hagman DK, Latour MG, Chakrabarti SK, Fontes G, Amyot J, Tremblay C, Semache M, Lausier JA, Roskens V, Mirmira RG, Jetton TL, Poitout V.

    Diabetes. 2008 Feb;57(2):424-31. Epub 2007 Nov 8.PMID: 17991758 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.

    Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP.

    Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10857-62.PMID: 10485916 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

    Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF.

    Diabetes. 2000 Mar;49(3):399-408.PMID: 10868961 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

    Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

    Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men.

    Xiao C, Giacca A, Lewis GF.

    Diabetologia. 2008 Jan;51(1):139-46. Epub 2007 Nov 17.PMID: 18026714 [PubMed - indexed for MEDLINE]Related articles

    18.

    Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.

    Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT.

    Diabetes. 1998 Oct;47(10):1613-8.PMID: 9753300 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

    Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M.

    Diabetes. 1999 Dec;48(12):2398-406.PMID: 10580429 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Role and mechanism of rosiglitazone on the impairment of insulin secretion induced by free fatty acids on isolated rat islets.

    Tian JY, Li G, Gu YY, Zhang HL, Zhou WZ, Wang X, Zhu HD, Luo TH, Luo M.

    Chin Med J (Engl). 2006 Apr 5;119(7):574-80.PMID: 16620699 [PubMed - indexed for MEDLINE]Related articlesFree article

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