PubMed

Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects.

Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Sirén J, Hamsten A, Fisher RM, Yki-Järvinen H.

Diabetes. 2007 Nov;56(11):2759-65. Epub 2007 Aug 17.PMID: 17704301 [PubMed - indexed for MEDLINE]Related articlesFree article

Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

Kohjima M, Enjoji M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Fujino T, Yada M, Yada R, Harada N, Takayanagi R, Nakamuta M.

Int J Mol Med. 2007 Sep;20(3):351-8.PMID: 17671740 [PubMed - indexed for MEDLINE]Related articles

The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs.

Gayet C, Leray V, Saito M, Siliart B, Nguyen P.

Br J Nutr. 2007 Sep;98(3):497-503. Epub 2007 May 3.PMID: 17475082 [PubMed - indexed for MEDLINE]Related articles

Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue.

Saravanan N, Haseeb A, Ehtesham NZ, Ghafoorunissa.

Eur J Endocrinol. 2005 Jul;153(1):159-65.PMID: 15998628 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.

Kolak M, Westerbacka J, Velagapudi VR, Wågsäter D, Yetukuri L, Makkonen J, Rissanen A, Häkkinen AM, Lindell M, Bergholm R, Hamsten A, Eriksson P, Fisher RM, Oresic M, Yki-Järvinen H.

Diabetes. 2007 Aug;56(8):1960-8. Epub 2007 Jul 9.PMID: 17620421 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle.

Lapsys NM, Kriketos AD, Lim-Fraser M, Poynten AM, Lowy A, Furler SM, Chisholm DJ, Cooney GJ.

J Clin Endocrinol Metab. 2000 Nov;85(11):4293-7.PMID: 11095470 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammation is associated with a decrease of lipogenic factors in omental fat in women.

Poulain-Godefroy O, Lecoeur C, Pattou F, Frühbeck G, Froguel P.

Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R1-7. Epub 2008 Apr 30.PMID: 18448614 [PubMed - indexed for MEDLINE]Related articles

Insulin regulation of MCP-1 in human adipose tissue of obese and lean women.

Westerbacka J, Cornér A, Kolak M, Makkonen J, Turpeinen U, Hamsten A, Fisher RM, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E841-5. Epub 2008 Feb 12.PMID: 18270300 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages.

Askari B, Kanter JE, Sherrid AM, Golej DL, Bender AT, Liu J, Hsueh WA, Beavo JA, Coleman RA, Bornfeldt KE.

Diabetes. 2007 Apr;56(4):1143-52. Epub 2007 Jan 26.PMID: 17259370 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet.

Nagasawa T, Inada Y, Nakano S, Tamura T, Takahashi T, Maruyama K, Yamazaki Y, Kuroda J, Shibata N.

Eur J Pharmacol. 2006 Apr 24;536(1-2):182-91. Epub 2006 Feb 28.PMID: 16574099 [PubMed - indexed for MEDLINE]Related articles

Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.

Sarov-Blat L, Kiss RS, Haidar B, Kavaslar N, Jaye M, Bertiaux M, Steplewski K, Hurle MR, Sprecher D, McPherson R, Marcel YL.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1115-22. Epub 2007 Feb 22.PMID: 17322100 [PubMed - indexed for MEDLINE]Related articlesFree article

Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study.

Chacón MR, Fernández-Real JM, Richart C, Megía A, Gómez JM, Miranda M, Caubet E, Pastor R, Masdevall C, Vilarrasa N, Ricard W, Vendrell J.

Obesity (Silver Spring). 2007 Mar;15(3):664-72.PMID: 17372317 [PubMed - indexed for MEDLINE]Related articles

The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo.

Bogacka I, Xie H, Bray GA, Smith SR.

Diabetes Care. 2004 Jul;27(7):1660-7.PMID: 15220243 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression in human NAFLD.

Greco D, Kotronen A, Westerbacka J, Puig O, Arkkila P, Kiviluoto T, Laitinen S, Kolak M, Fisher RM, Hamsten A, Auvinen P, Yki-Järvinen H.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1281-7. Epub 2008 Apr 3.PMID: 18388185 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression.

Li L, Beauchamp MC, Renier G.

Atherosclerosis. 2002 Nov;165(1):101-10.PMID: 12208475 [PubMed - indexed for MEDLINE]Related articles

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.

Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J.

J Nutr Biochem. 2008 Apr;19(4):216-28. Epub 2007 Jul 6.PMID: 17618105 [PubMed - indexed for MEDLINE]Related articles

Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy.

Sutinen J, Kannisto K, Korsheninnikova E, Fisher RM, Ehrenborg E, Nyman T, Virkamäki A, Funahashi T, Matsuzawa Y, Vidal H, Hamsten A, Yki-Järvinen H.

Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E941-9. Epub 2004 Jan 28.PMID: 14749206 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease.

Nakamuta M, Kohjima M, Morizono S, Kotoh K, Yoshimoto T, Miyagi I, Enjoji M.

Int J Mol Med. 2005 Oct;16(4):631-5.PMID: 16142397 [PubMed - indexed for MEDLINE]Related articles

Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease.

Yeon JE, Choi KM, Baik SH, Kim KO, Lim HJ, Park KH, Kim JY, Park JJ, Kim JS, Bak YT, Byun KS, Lee CH.

J Gastroenterol Hepatol. 2004 Jul;19(7):799-804.PMID: 15209628 [PubMed - indexed for MEDLINE]Related articles

The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease.

Nakamuta M, Kohjima M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, Yada M, Yada R, Takemoto R, Fukuizumi K, Harada N, Taketomi A, Maehara Y, Nakashima M, Enjoji M.

Int J Mol Med. 2008 Nov;22(5):663-7.PMID: 18949388 [PubMed - indexed for MEDLINE]Related articles