PubMed

A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.

Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ.

Diabetes. 2007 Nov;56(11):2744-52. Epub 2007 Aug 13.PMID: 17698597 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplantation of PC1/3-Expressing alpha-cells improves glucose handling and cold tolerance in leptin-resistant mice.

Wideman RD, Gray SL, Covey SD, Webb GC, Kieffer TJ.

Mol Ther. 2009 Jan;17(1):191-8. Epub 2008 Oct 21.PMID: 18941442 [PubMed - indexed for MEDLINE]Related articles

Proglucagon processing in an islet cell line: effects of PC1 overexpression and PC2 depletion.

Dhanvantari S, Brubaker PL.

Endocrinology. 1998 Apr;139(4):1630-7.PMID: 9528943 [PubMed - indexed for MEDLINE]Related articlesFree article

Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).

Wideman RD, Yu IL, Webber TD, Verchere CB, Johnson JD, Cheung AT, Kieffer TJ.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13468-73. Epub 2006 Aug 28.PMID: 16938896 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets.

Webb GC, Dey A, Wang J, Stein J, Milewski M, Steiner DF.

J Biol Chem. 2004 Jul 23;279(30):31068-75. Epub 2004 May 13.PMID: 15143067 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

Ugleholdt R, Zhu X, Deacon CF, Ørskov C, Steiner DF, Holst JJ.

Endocrinology. 2004 Mar;145(3):1349-55. Epub 2003 Nov 20.PMID: 14630721 [PubMed - indexed for MEDLINE]Related articlesFree article

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.

Ugleholdt R, Poulsen ML, Holst PJ, Irminger JC, Orskov C, Pedersen J, Rosenkilde MM, Zhu X, Steiner DF, Holst JJ.

J Biol Chem. 2006 Apr 21;281(16):11050-7. Epub 2006 Feb 13.PMID: 16476726 [PubMed - indexed for MEDLINE]Related articlesFree article

Proglucagon processing profile in canine L cells expressing endogenous prohormone convertase 1/3 and prohormone convertase 2.

Damholt AB, Buchan AM, Holst JJ, Kofod H.

Endocrinology. 1999 Oct;140(10):4800-8.PMID: 10499540 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats.

Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, Jansen E, Zambre Y, Pipeleers D, Friedman TC.

J Clin Invest. 2000 Apr;105(7):955-65.PMID: 10749575 [PubMed - indexed for MEDLINE]Related articlesFree article

Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.

Dhanvantari S, Izzo A, Jansen E, Brubaker PL.

Endocrinology. 2001 Jan;142(1):37-42.PMID: 11145564 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.

Rouillé Y, Martin S, Steiner DF.

J Biol Chem. 1995 Nov 3;270(44):26488-96.PMID: 7592866 [PubMed - indexed for MEDLINE]Related articlesFree article

Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon.

Dey A, Lipkind GM, Rouillé Y, Norrbom C, Stein J, Zhang C, Carroll R, Steiner DF.

Endocrinology. 2005 Feb;146(2):713-27. Epub 2004 Nov 4.PMID: 15528303 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats.

Cani PD, Daubioul CA, Reusens B, Remacle C, Catillon G, Delzenne NM.

J Endocrinol. 2005 Jun;185(3):457-65.PMID: 15930172 [PubMed - indexed for MEDLINE]Related articlesFree article

Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.

Rothenberg ME, Eilertson CD, Klein K, Zhou Y, Lindberg I, McDonald JK, Mackin RB, Noe BD.

J Biol Chem. 1995 Apr 28;270(17):10136-46.PMID: 7730317 [PubMed - indexed for MEDLINE]Related articlesFree article

Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

Rouillé Y, Westermark G, Martin SK, Steiner DF.

Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3242-6.PMID: 8159732 [PubMed - indexed for MEDLINE]Related articlesFree article

How the hindgut can cure type 2 diabetes. Ileal transposition improves glucose metabolism and beta-cell function in Goto-kakizaki rats through an enhanced Proglucagon gene expression and L-cell number.

Patriti A, Aisa MC, Annetti C, Sidoni A, Galli F, Ferri I, Gullà N, Donini A.

Surgery. 2007 Jul;142(1):74-85.PMID: 17630003 [PubMed - indexed for MEDLINE]Related articles

The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.

Maida A, Lovshin JA, Baggio LL, Drucker DJ.

Endocrinology. 2008 Nov;149(11):5670-8. Epub 2008 Jul 31.PMID: 18669601 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.

Rouillé Y, Kantengwa S, Irminger JC, Halban PA.

J Biol Chem. 1997 Dec 26;272(52):32810-6.PMID: 9407057 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of prohormone convertases in the tissue-specific processing of proglucagon.

Dhanvantari S, Seidah NG, Brubaker PL.

Mol Endocrinol. 1996 Apr;10(4):342-55.PMID: 8721980 [PubMed - indexed for MEDLINE]Related articles

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.

Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.

Diabetes. 2004 Jan;53(1):141-8.PMID: 14693708 [PubMed - indexed for MEDLINE]Related articlesFree article