PubMed

Chondroprotective effects of a proanthocyanidin rich Amazonian genonutrient reflects direct inhibition of matrix metalloproteinases and upregulation of IGF-1 production by human chondrocytes.

Miller MJ, Bobrowski P, Shukla M, Gupta K, Haqqi TM.

J Inflamm (Lond). 2007 Aug 14;4:16.PMID: 17697350 [PubMed - in process]Related articlesFree article

The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta.

Miller MJ, Ahmed S, Bobrowski P, Haqqi TM.

BMC Complement Altern Med. 2006 Apr 7;6:13.PMID: 16603065 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.

Zayed N, Afif H, Chabane N, Mfuna-Endam L, Benderdour M, Martel-Pelletier J, Pelletier JP, Motiani RK, Trebak M, Duval N, Fahmi H.

Arthritis Rheum. 2008 Nov;58(11):3530-40.PMID: 18975308 [PubMed - indexed for MEDLINE]Related articlesFree article

A unique therapeutic approach to emesis and itch with a proanthocyanidin-rich genonutrient.

Miller MJ, Reuter BK, Wallace JL, Sharkey KA.

J Transl Med. 2008 Jan 18;6:3.PMID: 18205911 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of electrical fields on gene and protein expression in human osteoarthritic cartilage explants.

Brighton CT, Wang W, Clark CC.

J Bone Joint Surg Am. 2008 Apr;90(4):833-48.PMID: 18381322 [PubMed - indexed for MEDLINE]Related articles

Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.

Chabane N, Zayed N, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H.

Arthritis Res Ther. 2009;11(2):R44. Epub 2009 Mar 18.PMID: 19296842 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.

Sawaji Y, Hynes J, Vincent T, Saklatvala J.

Arthritis Rheum. 2008 Nov;58(11):3498-509.PMID: 18975307 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Wnt-5A in interleukin-1beta-induced matrix metalloproteinase expression in rabbit temporomandibular joint condylar chondrocytes.

Ge X, Ma X, Meng J, Zhang C, Ma K, Zhou C.

Arthritis Rheum. 2009 Sep;60(9):2714-22.PMID: 19714632 [PubMed - indexed for MEDLINE]Related articles

The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death.

Kimura H, Yukitake H, Suzuki H, Tajima Y, Gomaibashi K, Morimoto S, Funabashi Y, Yamada K, Takizawa M.

J Pharmacol Sci. 2009 Jun;110(2):201-11.PMID: 19542681 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study.

Boileau C, Amiable N, Martel-Pelletier J, Fahmi H, Duval N, Pelletier JP.

Arthritis Res Ther. 2007;9(6):R121.PMID: 18031579 [PubMed - indexed for MEDLINE]Related articlesFree article

Anabolic actions of IGF-I and TGF-beta1 on Interleukin-1beta-treated human articular chondrocytes: evaluation in two and three dimensional cultures.

Seifarth C, Csaki C, Shakibaei M.

Histol Histopathol. 2009 Oct;24(10):1245-62.PMID: 19688693 [PubMed - indexed for MEDLINE]Related articles

Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta.

Sandell LJ, Xing X, Franz C, Davies S, Chang LW, Patra D.

Osteoarthritis Cartilage. 2008 Dec;16(12):1560-71. Epub 2008 Jun 18.PMID: 18565769 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes.

Wang X, Song Y, Jacobi JL, Tuan RS.

Growth Factors. 2009 Feb;27(1):40-9.PMID: 19107653 [PubMed - indexed for MEDLINE]Related articles

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13.

Long D, Blake S, Song XY, Lark M, Loeser RF.

Arthritis Res Ther. 2008;10(1):R23. Epub 2008 Feb 20.PMID: 18289383 [PubMed - indexed for MEDLINE]Related articlesFree article

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.

Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM Jr, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D, Nolte B, Piecha D, Powers TS, Richter F, Schneider M, Steeneck C, Sucholeiki I, Taveras A, Timmermann A, Van Veldhuizen J, Weik J, Wu X, Xia B.

Arthritis Rheum. 2009 Jul;60(7):2008-18.PMID: 19565489 [PubMed - indexed for MEDLINE]Related articles

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study.

Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M.

Arthritis Res Ther. 2008;10(1):R9. Epub 2008 Jan 18.PMID: 18205922 [PubMed - indexed for MEDLINE]Related articlesFree article

Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytes.

Kim HA, Yeo Y, Kim WU, Kim S.

Rheumatology (Oxford). 2009 Aug;48(8):932-8. Epub 2009 Jun 2.PMID: 19491303 [PubMed - indexed for MEDLINE]Related articles

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.

Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lavigne M, Martel-Pelletier J.

Arthritis Res Ther. 2009;11(4):R119. Epub 2009 Aug 7.PMID: 19664212 [PubMed - indexed for MEDLINE]Related articlesFree article

Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: role of IL-1beta and 15-HETE.

Prato M, Gallo V, Giribaldi G, Arese P.

Malar J. 2008 Aug 18;7:157.PMID: 18710562 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants.

Stevens AL, Wheeler CA, Tannenbaum SR, Grodzinsky AJ.

Osteoarthritis Cartilage. 2008 Apr;16(4):489-97. Epub 2007 Oct 10.PMID: 17923423 [PubMed - indexed for MEDLINE]Related articles