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Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis.
Vasavada RC, Wang L, Fujinaka Y, Takane KK, Rosa TC, Mellado-Gil JM, Friedman PA, Garcia-Ocaña A.
Diabetes. 2007 Nov;56(11):2732-43. Epub 2007 Aug 8.PMID: 17686945 [PubMed - indexed for MEDLINE]Related articlesFree article
Growth hormone- and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5).
Friedrichsen BN, Galsgaard ED, Nielsen JH, Møldrup A.
Mol Endocrinol. 2001 Jan;15(1):136-48.PMID: 11145745 [PubMed - indexed for MEDLINE]Related articlesFree article
Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.
J Mol Endocrinol. 2003 Jun;30(3):271-86.PMID: 12790799 [PubMed - indexed for MEDLINE]Related articlesFree article
Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth.
Cai W, Rook SL, Jiang ZY, Takahara N, Aiello LP.
Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1885-93.PMID: 10845613 [PubMed - indexed for MEDLINE]Related articlesFree article
PTHrP signaling targets cyclin D1 and induces osteoblastic cell growth arrest.
Datta NS, Chen C, Berry JE, McCauley LK.
J Bone Miner Res. 2005 Jun;20(6):1051-64. Epub 2005 Jan 18.PMID: 15883646 [PubMed - indexed for MEDLINE]Related articles
Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.
García-Ocaña A, Vasavada RC, Cebrian A, Reddy V, Takane KK, López-Talavera JC, Stewart AF.
Diabetes. 2001 Dec;50(12):2752-62.PMID: 11723058 [PubMed - indexed for MEDLINE]Related articlesFree article
Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death.
Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF.
J Biol Chem. 2003 Jan 3;278(1):343-51. Epub 2002 Oct 25.PMID: 12403787 [PubMed - indexed for MEDLINE]Related articlesFree article
Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia.
Garcia-Ocaña A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF.
J Biol Chem. 2000 Jan 14;275(2):1226-32.PMID: 10625667 [PubMed - indexed for MEDLINE]Related articlesFree article
Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations.
Gahr S, Merger M, Bollheimer LC, Hammerschmied CG, Schölmerich J, Hügl SR.
J Mol Endocrinol. 2002 Apr;28(2):99-110.PMID: 11932207 [PubMed - indexed for MEDLINE]Related articlesFree article
Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.
Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.
Diabetes. 2008 May;57(5):1195-204. Epub 2008 Feb 14.PMID: 18276765 [PubMed - indexed for MEDLINE]Related articlesFree article
Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer.
Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, Sasaki A, Takigawa M.
J Bone Miner Res. 2006 Jul;21(7):1045-59.PMID: 16813525 [PubMed - indexed for MEDLINE]Related articles
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Buteau J, Foisy S, Rhodes CJ, Carpenter L, Biden TJ, Prentki M.
Diabetes. 2001 Oct;50(10):2237-43.PMID: 11574404 [PubMed - indexed for MEDLINE]Related articlesFree article
A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Schuppin GT, Pons S, Hügl S, Aiello LP, King GL, White M, Rhodes CJ.
Diabetes. 1998 Jul;47(7):1074-85.PMID: 9648831 [PubMed - indexed for MEDLINE]Related articlesFree article
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
Cousin SP, Hügl SR, Myers MG Jr, White MF, Reifel-Miller A, Rhodes CJ.
Biochem J. 1999 Dec 15;344 Pt 3:649-58.PMID: 10585851 [PubMed - indexed for MEDLINE]Related articlesFree article
Characterization of mice doubly transgenic for parathyroid hormone-related protein and murine placental lactogen: a novel role for placental lactogen in pancreatic beta-cell survival.
Fujinaka Y, Sipula D, Garcia-Ocaña A, Vasavada RC.
Diabetes. 2004 Dec;53(12):3120-30.PMID: 15561942 [PubMed - indexed for MEDLINE]Related articlesFree article
Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway.
Miao D, Tong XK, Chan GK, Panda D, McPherson PS, Goltzman D.
J Biol Chem. 2001 Aug 24;276(34):32204-13. Epub 2001 Jun 11.PMID: 11402023 [PubMed - indexed for MEDLINE]Related articlesFree article
Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.
Lindberg K, Rønn SG, Tornehave D, Richter H, Hansen JA, Rømer J, Jackerott M, Billestrup N.
J Mol Endocrinol. 2005 Oct;35(2):231-43.PMID: 16216905 [PubMed - indexed for MEDLINE]Related articlesFree article
Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.
Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA.
Diabetologia. 2008 Apr;51(4):623-31. Epub 2008 Jan 25.PMID: 18219478 [PubMed - indexed for MEDLINE]Related articles
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.
J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.PMID: 11274216 [PubMed - indexed for MEDLINE]Related articlesFree article
Glucose stimulates islet beta-cell mitogenesis through GTP-binding proteins and by protein kinase C-dependent mechanisms.
Sjöholm A.
Diabetes. 1997 Jul;46(7):1141-7.PMID: 9200648 [PubMed - indexed for MEDLINE]Related articles
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