PubMed

beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS.

Diabetes. 2007 Oct;56(10):2569-78. Epub 2007 Aug 8.PMID: 17686943 [PubMed - indexed for MEDLINE]Related articlesFree article

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB.

Cell Metab. 2006 Jun;3(6):417-27.PMID: 16753577 [PubMed - indexed for MEDLINE]Related articles

Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells.

Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE.

Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E143-E148. Epub 2005 Sep 6.PMID: 16144817 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Produit-Zengaffinen N, Davis-Lameloise N, Perreten H, Bécard D, Gjinovci A, Keller PA, Wollheim CB, Herrera P, Muzzin P, Assimacopoulos-Jeannet F.

Diabetologia. 2007 Jan;50(1):84-93. Epub 2006 Nov 28.PMID: 17131143 [PubMed - indexed for MEDLINE]Related articles

Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE.

Biochem J. 2007 Apr 1;403(1):197-205.PMID: 17181533 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

Nat Med. 2008 Feb;14(2):144-53. Epub 2008 Jan 27.PMID: 18223655 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion.

Zhou YP, Pena JC, Roe MW, Mittal A, Levisetti M, Baldwin AC, Pugh W, Ostrega D, Ahmed N, Bindokas VP, Philipson LH, Hanahan D, Thompson CB, Polonsky KS.

Am J Physiol Endocrinol Metab. 2000 Feb;278(2):E340-51.PMID: 10662719 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.

Urban KA, Panten U.

Diabetologia. 2005 Dec;48(12):2563-6. Epub 2005 Nov 11.PMID: 16283243 [PubMed - indexed for MEDLINE]Related articles

Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets.

Pascal SM, Guiot Y, Pelengaris S, Khan M, Jonas JC.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E92-102. Epub 2008 Apr 15.PMID: 18413670 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.

Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB.

J Biol Chem. 2002 Apr 5;277(14):11746-55. Epub 2002 Jan 30.PMID: 11821387 [PubMed - indexed for MEDLINE]Related articlesFree article

Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.

Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH.

Diabetes. 2006 Oct;55(10):2730-6.PMID: 17003337 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucosamine-induced alterations of mitochondrial function in pancreatic beta-cells: possible role of protein glycosylation.

Anello M, Spampinato D, Piro S, Purrello F, Rabuazzo AM.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E602-8. Epub 2004 May 18.PMID: 15149952 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy.

Cui Y, Xu X, Bi H, Zhu Q, Wu J, Xia X, Qiushi Ren, Ho PC.

Exp Eye Res. 2006 Oct;83(4):807-16. Epub 2006 Jun 5.PMID: 16750827 [PubMed - indexed for MEDLINE]Related articles

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.

Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A.

Diabetes. 2008 Apr;57(4):938-44. Epub 2008 Jan 2.PMID: 18171713 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG.

Nat Genet. 2000 Nov;26(3):336-40.PMID: 11062475 [PubMed - indexed for MEDLINE]Related articles

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Fex M, Nitert MD, Wierup N, Sundler F, Ling C, Mulder H.

Diabetologia. 2007 Jan;50(1):74-83. Epub 2006 Nov 9.PMID: 17093947 [PubMed - indexed for MEDLINE]Related articles

Measurements of cytoplasmic Ca2+ in islet cell clusters show that glucose rapidly recruits beta-cells and gradually increases the individual cell response.

Jonkers FC, Henquin JC.

Diabetes. 2001 Mar;50(3):540-50.PMID: 11246873 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.

Ward MW, Huber HJ, Weisová P, Düssmann H, Nicholls DG, Prehn JH.

J Neurosci. 2007 Aug 1;27(31):8238-49.PMID: 17670970 [PubMed - indexed for MEDLINE]Related articlesFree article