PubMed

Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.

Tchetina EV, Di Battista JA, Zukor DJ, Antoniou J, Poole AR.

Arthritis Res Ther. 2007;9(4):R75.PMID: 17683641 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.

Tchetina EV, Antoniou J, Tanzer M, Zukor DJ, Poole AR.

Am J Pathol. 2006 Jan;168(1):131-40.PMID: 16400016 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.

Tchetina EV, Squires G, Poole AR.

J Rheumatol. 2005 May;32(5):876-86.PMID: 15868625 [PubMed - indexed for MEDLINE]Related articles

Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.

Roman-Blas JA, Stokes DG, Jimenez SA.

Osteoarthritis Cartilage. 2007 Dec;15(12):1367-77. Epub 2007 Jun 29.PMID: 17604656 [PubMed - indexed for MEDLINE]Related articlesFree article

Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.

Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR.

Matrix Biol. 2006 Sep;25(7):419-29. Epub 2006 Jun 30.PMID: 16919430 [PubMed - indexed for MEDLINE]Related articles

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.

Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR.

Arthritis Rheum. 2005 Jan;52(1):128-35.PMID: 15641080 [PubMed - indexed for MEDLINE]Related articlesFree article

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.

Tchetina EV, Kobayashi M, Yasuda T, Meijers T, Pidoux I, Poole AR.

Matrix Biol. 2007 May;26(4):247-58. Epub 2007 Jan 19.PMID: 17306969 [PubMed - indexed for MEDLINE]Related articles

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).

Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR.

Arthritis Rheum. 2000 Mar;43(3):673-82.PMID: 10728762 [PubMed - indexed for MEDLINE]Related articlesFree article

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses.

Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz MK, Asahara H.

Arthritis Rheum. 2009 Sep;60(9):2723-30.PMID: 19714579 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis.

Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F.

Arthritis Rheum. 2007 Nov;56(11):3693-705.PMID: 17968906 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy.

Brew CJ, Clegg PD, Boot-Handford RP, Andrew JG, Hardingham T.

Ann Rheum Dis. 2010 Jan;69(1):234-40. Epub .PMID: 19103633 [PubMed - indexed for MEDLINE]Related articles

[Type II collagen fragment capacity to induce collagen cleavage and hypertrophy of articular chondrocyte]

Chetkina EV, Pul AR.

Vestn Ross Akad Med Nauk. 2008;(5):15-21. Russian. PMID: 18589731 [PubMed - indexed for MEDLINE]Related articles

Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis.

Li X, Ellman M, Muddasani P, Wang JH, Cs-Szabo G, van Wijnen AJ, Im HJ.

Arthritis Rheum. 2009 Feb;60(2):513-23.PMID: 19180509 [PubMed - indexed for MEDLINE]Related articlesFree article

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.

Wu W, Billinghurst RC, Pidoux I, Antoniou J, Zukor D, Tanzer M, Poole AR.

Arthritis Rheum. 2002 Aug;46(8):2087-94.PMID: 12209513 [PubMed - indexed for MEDLINE]Related articlesFree article

Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta.

Fan Z, Bau B, Yang H, Soeder S, Aigner T.

Arthritis Rheum. 2005 Jan;52(1):136-43.PMID: 15641077 [PubMed - indexed for MEDLINE]Related articlesFree article

Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.

Maneiro E, López-Armada MJ, Fernández-Sueiro JL, Lema B, Galdo F, Blanco FJ.

J Rheumatol. 2001 Dec;28(12):2692-9.PMID: 11764219 [PubMed - indexed for MEDLINE]Related articles

Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9.

Cucchiarini M, Thurn T, Weimer A, Kohn D, Terwilliger EF, Madry H.

Arthritis Rheum. 2007 Jan;56(1):158-67.PMID: 17195218 [PubMed - indexed for MEDLINE]Related articlesFree article

ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage.

Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, Matsumoto H, Sehara-Fujisawa A, Iwamoto Y, Okada Y.

Arthritis Rheum. 2008 Mar;58(3):778-89.PMID: 18311789 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.

Tew SR, Li Y, Pothacharoen P, Tweats LM, Hawkins RE, Hardingham TE.

Osteoarthritis Cartilage. 2005 Jan;13(1):80-9.PMID: 15639641 [PubMed - indexed for MEDLINE]Related articles

Effects of proinflammatory cytokines on canine articular chondrocytes in a three-dimensional culture.

Kuroki K, Stoker AM, Cook JL.

Am J Vet Res. 2005 Jul;66(7):1187-96.PMID: 16111157 [PubMed - indexed for MEDLINE]Related articles