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    Results: 1 to 20 of 308

    1.

    High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition.

    Obrosova IG, Ilnytska O, Lyzogubov VV, Pavlov IA, Mashtalir N, Nadler JL, Drel VR.

    Diabetes. 2007 Oct;56(10):2598-608. Epub 2007 Jul 12.PMID: 17626889 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice.

    Vareniuk I, Pavlov IA, Drel VR, Lyzogubov VV, Ilnytska O, Bell SR, Tibrewala J, Groves JT, Obrosova IG.

    Exp Neurol. 2007 Jun;205(2):425-36. Epub 2007 Mar 27.PMID: 17475250 [PubMed - indexed for MEDLINE]Related articles

    3.

    The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity.

    Drel VR, Mashtalir N, Ilnytska O, Shin J, Li F, Lyzogubov VV, Obrosova IG.

    Diabetes. 2006 Dec;55(12):3335-43.PMID: 17130477 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes.

    Vareniuk I, Pavlov IA, Obrosova IG.

    Diabetologia. 2008 Nov;51(11):2126-33. Epub 2008 Sep 19.PMID: 18802679 [PubMed - indexed for MEDLINE]Related articles

    5.

    Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes.

    Drel VR, Pacher P, Vareniuk I, Pavlov IA, Ilnytska O, Lyzogubov VV, Bell SR, Groves JT, Obrosova IG.

    Int J Mol Med. 2007 Dec;20(6):783-92.PMID: 17982684 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice.

    Drel VR, Pacher P, Vareniuk I, Pavlov I, Ilnytska O, Lyzogubov VV, Tibrewala J, Groves JT, Obrosova IG.

    Eur J Pharmacol. 2007 Aug 13;569(1-2):48-58. Epub 2007 Jun 9.PMID: 17644085 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency.

    Vareniuk I, Pacher P, Pavlov IA, Drel VR, Obrosova IG.

    Int J Mol Med. 2009 May;23(5):571-80.PMID: 19360314 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications.

    Obrosova IG, Pacher P, Szabó C, Zsengeller Z, Hirooka H, Stevens MJ, Yorek MA.

    Diabetes. 2005 Jan;54(1):234-42.PMID: 15616034 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor.

    Calcutt NA, Freshwater JD, Mizisin AP.

    Diabetologia. 2004 Apr;47(4):718-24.PMID: 15298349 [PubMed - indexed for MEDLINE]Related articles

    10.

    A novel model of type 2 diabetes mellitus based on obesity induced by high-fat diet in BDF1 mice.

    Karasawa H, Nagata-Goto S, Takaishi K, Kumagae Y.

    Metabolism. 2009 Mar;58(3):296-303.PMID: 19217442 [PubMed - indexed for MEDLINE]Related articles

    11.

    Effect of the aldose reductase inhibitor fidarestat on experimental diabetic neuropathy in the rat.

    Kuzumoto Y, Kusunoki S, Kato N, Kihara M, Low PA.

    Diabetologia. 2006 Dec;49(12):3085-93. Epub 2006 Oct 25.PMID: 17063327 [PubMed - indexed for MEDLINE]Related articles

    12.

    Continuous inhibition of excessive polyol pathway flux in peripheral nerves by aldose reductase inhibitor fidarestat leads to improvement of diabetic neuropathy.

    Mizuno K, Kato N, Makino M, Suzuki T, Shindo M.

    J Diabetes Complications. 1999 May-Jun;13(3):141-50.PMID: 10509874 [PubMed - indexed for MEDLINE]Related articles

    13.

    Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.

    Calcutt NA, Jorge MC, Yaksh TL, Chaplan SR.

    Pain. 1996 Dec;68(2-3):293-9.PMID: 9121817 [PubMed - indexed for MEDLINE]Related articles

    14.

    An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.

    Obrosova IG, Van Huysen C, Fathallah L, Cao XC, Greene DA, Stevens MJ.

    FASEB J. 2002 Jan;16(1):123-5. Epub 2001 Nov 14.PMID: 11709499 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Neuropathy in diabetic mice overexpressing human aldose reductase and effects of aldose reductase inhibitor.

    Yagihashi S, Yamagishi SI, Wada Ri R, Baba M, Hohman TC, Yabe-Nishimura C, Kokai Y.

    Brain. 2001 Dec;124(Pt 12):2448-58.PMID: 11701599 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.

    Kato N, Mizuno K, Makino M, Suzuki T, Yagihashi S.

    Diabetes Res Clin Pract. 2000 Oct;50(2):77-85.PMID: 10960717 [PubMed - indexed for MEDLINE]Related articles

    17.

    Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat.

    Sima AA, Prashar A, Zhang WX, Chakrabarti S, Greene DA.

    J Clin Invest. 1990 May;85(5):1410-20.PMID: 2110189 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.

    Price SA, Agthong S, Middlemas AB, Tomlinson DR.

    Diabetes. 2004 Jul;53(7):1851-6.PMID: 15220210 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study.

    Hotta N, Toyota T, Matsuoka K, Shigeta Y, Kikkawa R, Kaneko T, Takahashi A, Sugimura K, Koike Y, Ishii J, Sakamoto N; SNK-860 Diabetic Neuropathy Study Group.

    Diabetes Care. 2001 Oct;24(10):1776-82. Erratum in: Diabetes Care 2002 Feb;25(2):413-4. PMID: 11574441 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.

    Obrosova IG, Xu W, Lyzogubov VV, Ilnytska O, Mashtalir N, Vareniuk I, Pavlov IA, Zhang J, Slusher B, Drel VR.

    Free Radic Biol Med. 2008 Mar 15;44(6):972-81. Epub 2007 Oct 3.PMID: 17976390 [PubMed - indexed for MEDLINE]Related articles

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