PubMed

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED.

Diabetes. 2007 Oct;56(10):2457-66. Epub 2007 Jul 10.PMID: 17623815 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED.

Diabetes. 2008 Nov;57(11):2924-32. Epub 2008 Aug 4.PMID: 18678617 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.

Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED.

Circulation. 2005 Oct 25;112(17):2686-95.PMID: 16246967 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial adaptations to obesity-related oxidant stress.

Yang S, Zhu H, Li Y, Lin H, Gabrielson K, Trush MA, Diehl AM.

Arch Biochem Biophys. 2000 Jun 15;378(2):259-68.PMID: 10860543 [PubMed - indexed for MEDLINE]Related articles

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. Epub 2008 May 16.PMID: 18487436 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart.

Murray AJ, Cole MA, Lygate CA, Carr CA, Stuckey DJ, Little SE, Neubauer S, Clarke K.

J Mol Cell Cardiol. 2008 Apr;44(4):694-700. Epub 2008 Feb 9.PMID: 18328500 [PubMed - indexed for MEDLINE]Related articles

Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice.

How OJ, Aasum E, Severson DL, Chan WY, Essop MF, Larsen TS.

Diabetes. 2006 Feb;55(2):466-73.PMID: 16443782 [PubMed - indexed for MEDLINE]Related articlesFree article

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ.

Diabetes. 2007 Aug;56(8):2085-92. Epub 2007 May 22.PMID: 17519422 [PubMed - indexed for MEDLINE]Related articlesFree article

What are the biochemical mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabetic db/db mice?

Carley AN, Severson DL.

Cardiovasc Drugs Ther. 2008 Apr;22(2):83-9. Review.PMID: 18247111 [PubMed - indexed for MEDLINE]Related articles

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria.

Chen Q, Moghaddas S, Hoppel CL, Lesnefsky EJ.

Am J Physiol Cell Physiol. 2008 Feb;294(2):C460-6. Epub 2007 Dec 12.PMID: 18077608 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

MacLellan JD, Gerrits MF, Gowing A, Smith PJ, Wheeler MB, Harper ME.

Diabetes. 2005 Aug;54(8):2343-50.PMID: 16046300 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ, Cooksey RC, Litwin SE, Abel ED.

Endocrinology. 2005 Dec;146(12):5341-9. Epub 2005 Sep 1.PMID: 16141388 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration.

Anderson EJ, Yamazaki H, Neufer PD.

J Biol Chem. 2007 Oct 26;282(43):31257-66. Epub 2007 Aug 30.PMID: 17761668 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver mitochondrial properties from the obesity-resistant Lou/C rat.

Lacraz G, Couturier K, Taleux N, Servais S, Sibille B, Letexier D, Guigas B, Dubouchaud H, Leverve X, Favier R.

Int J Obes (Lond). 2008 Apr;32(4):629-38. Epub 2008 Jan 15.PMID: 18197185 [PubMed - indexed for MEDLINE]Related articles

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED.

Circulation. 2009 Mar 10;119(9):1272-83. Epub 2009 Feb 23.PMID: 19237663 [PubMed - indexed for MEDLINE]Related articles

Exercise training decreases rat heart mitochondria free radical generation but does not prevent Ca2+-induced dysfunction.

Starnes JW, Barnes BD, Olsen ME.

J Appl Physiol. 2007 May;102(5):1793-8. Epub 2007 Feb 15.PMID: 17303708 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of mitochondrial uncoupling respiration during exercise in rat heart: role of reactive oxygen species (ROS) and uncoupling protein 2.

Bo H, Jiang N, Ma G, Qu J, Zhang G, Cao D, Wen L, Liu S, Ji LL, Zhang Y.

Free Radic Biol Med. 2008 Apr 1;44(7):1373-81. Epub 2008 Jan 4.PMID: 18226608 [PubMed - indexed for MEDLINE]Related articles

Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart.

Boehm EA, Jones BE, Radda GK, Veech RL, Clarke K.

Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H977-83.PMID: 11179038 [PubMed - indexed for MEDLINE]Related articlesFree article

Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.

Redout EM, Wagner MJ, Zuidwijk MJ, Boer C, Musters RJ, van Hardeveld C, Paulus WJ, Simonides WS.

Cardiovasc Res. 2007 Sep 1;75(4):770-81. Epub 2007 May 17.PMID: 17582388 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy.

Cui Y, Xu X, Bi H, Zhu Q, Wu J, Xia X, Qiushi Ren, Ho PC.

Exp Eye Res. 2006 Oct;83(4):807-16. Epub 2006 Jun 5.PMID: 16750827 [PubMed - indexed for MEDLINE]Related articles