PubMed

Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice.

Kim S, Kim HS, Chung KW, Oh SH, Yun JW, Im SH, Lee MK, Kim KW, Lee MS.

Diabetes. 2007 Oct;56(10):2561-8. Epub 2007 Jul 9.PMID: 17620422 [PubMed - indexed for MEDLINE]Related articlesFree article

IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death.

Suk K, Kim S, Kim YH, Kim KA, Chang I, Yagita H, Shong M, Lee MS.

J Immunol. 2001 Apr 1;166(7):4481-9.PMID: 11254704 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN.

Lee HJ, Oh YK, Rhee M, Lim JY, Hwang JY, Park YS, Kwon Y, Choi KH, Jo I, Park SI, Gao B, Kim WH.

J Mol Biol. 2007 Jun 15;369(4):967-84. Epub 2007 Apr 1.PMID: 17475277 [PubMed - indexed for MEDLINE]Related articles

IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gamma.

Trembleau S, Penna G, Gregori S, Giarratana N, Adorini L.

J Immunol. 2003 Jun 1;170(11):5491-501.PMID: 12759426 [PubMed - indexed for MEDLINE]Related articlesFree article

Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction.

Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A.

Diabetes. 1996 Oct;45(10):1350-7.PMID: 8826970 [PubMed - indexed for MEDLINE]Related articles

An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus.

Rabinovitch A.

Diabetes Metab Rev. 1998 Jun;14(2):129-51. Review.PMID: 9679667 [PubMed - indexed for MEDLINE]Related articles

Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: identification of iNOS- expressing cells and relationships to cytokines expressed in the islets.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC.

Endocrinology. 1996 May;137(5):2093-9.PMID: 8612552 [PubMed - indexed for MEDLINE]Related articles

NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice.

Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS.

Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1913-8. Epub 2007 Jan 31.PMID: 17267600 [PubMed - indexed for MEDLINE]Related articlesFree article

A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice.

Han HS, Jun HS, Utsugi T, Yoon JW.

J Autoimmun. 1996 Jun;9(3):331-9.PMID: 8816968 [PubMed - indexed for MEDLINE]Related articles

Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL.

Am J Pathol. 1995 Nov;147(5):1193-9.PMID: 7485382 [PubMed - indexed for MEDLINE]Related articlesFree article

In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.

Pakala SV, Chivetta M, Kelly CB, Katz JD.

J Exp Med. 1999 Apr 5;189(7):1053-62.PMID: 10190896 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine signalling in the beta-cell: a dual role for IFNgamma.

Gysemans C, Callewaert H, Overbergh L, Mathieu C.

Biochem Soc Trans. 2008 Jun;36(Pt 3):328-33. Review.PMID: 18481951 [PubMed - indexed for MEDLINE]Related articles

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.

Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.

Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.PMID: 17473223 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent progress in research on beta-cell apoptosis by cytokines.

Kim KA, Lee MS.

Front Biosci. 2009 Jan 1;14:657-64. Review.PMID: 19273093 [PubMed - indexed for MEDLINE]Related articles

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells.

Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL.

Diabetologia. 2001 Mar;44(3):325-32.PMID: 11317664 [PubMed - indexed for MEDLINE]Related articles

Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene.

Serreze DV, Pierce MA, Post CM, Chapman HD, Savage H, Bronson RT, Rothman PB, Cox GA.

J Immunol. 2003 Mar 1;170(5):2742-9.PMID: 12594305 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes.

Amrani A, Verdaguer J, Thiessen S, Bou S, Santamaria P.

J Clin Invest. 2000 Feb;105(4):459-68.PMID: 10683375 [PubMed - indexed for MEDLINE]Related articlesFree article

IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF.

J Immunol. 1995 May 1;154(9):4874-82.PMID: 7722337 [PubMed - indexed for MEDLINE]Related articles

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.

Diabetes. 2005 Aug;54(8):2396-403.PMID: 16046307 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of autoimmune diabetes in NOD mice by troglitazone is associated with modulation of ICAM-1 expression on pancreatic islet cells and IFN-gamma expression in splenic T cells.

Augstein P, Dunger A, Heinke P, Wachlin G, Berg S, Hehmke B, Salzsieder E.

Biochem Biophys Res Commun. 2003 May 2;304(2):378-84.PMID: 12711326 [PubMed - indexed for MEDLINE]Related articles