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Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy.
Lindegaard B, Frøsig C, Petersen AM, Plomgaard P, Ditlevsen S, Mittendorfer B, Van Hall G, Wojtaszewski JF, Pedersen BK.
Diabetes. 2007 Aug;56(8):2070-7. Epub 2007 Jun 29.PMID: 17601993 [PubMed - indexed for MEDLINE]Related articlesFree article
Inhibition of lipolysis during acute GH exposure increases insulin sensitivity in previously untreated GH-deficient adults.
Segerlantz M, Bramnert M, Manhem P, Laurila E, Groop LC.
Eur J Endocrinol. 2003 Dec;149(6):511-9.PMID: 14640991 [PubMed - indexed for MEDLINE]Related articlesFree article
Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy.
Haugaard SB, Andersen O, Madsbad S, Frøsig C, Iversen J, Nielsen JO, Wojtaszewski JF.
Diabetes. 2005 Dec;54(12):3474-83.PMID: 16306364 [PubMed - indexed for MEDLINE]Related articlesFree article
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA.
Diabetes. 2005 Nov;54(11):3148-53.PMID: 16249438 [PubMed - indexed for MEDLINE]Related articlesFree article
Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia.
Hadigan C, Liebau J, Torriani M, Andersen R, Grinspoon S.
J Clin Endocrinol Metab. 2006 Nov;91(11):4438-44. Epub 2006 Aug 29.PMID: 16940448 [PubMed - indexed for MEDLINE]Related articlesFree article
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
Bajaj M, Suraamornkul S, Kashyap S, Cusi K, Mandarino L, DeFronzo RA.
J Clin Endocrinol Metab. 2004 Sep;89(9):4649-55.PMID: 15356076 [PubMed - indexed for MEDLINE]Related articlesFree article
Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.
Thong FS, Derave W, Kiens B, Graham TE, Ursø B, Wojtaszewski JF, Hansen BF, Richter EA.
Diabetes. 2002 Mar;51(3):583-90.PMID: 11872654 [PubMed - indexed for MEDLINE]Related articlesFree article
Inhibition of lipolysis improves insulin sensitivity in protease inhibitor-treated HIV-infected men with fat redistribution.
Hadigan C, Rabe J, Meininger G, Aliabadi N, Breu J, Grinspoon S.
Am J Clin Nutr. 2003 Feb;77(2):490-4.PMID: 12540412 [PubMed - indexed for MEDLINE]Related articlesFree article
Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.
Vaag A, Skött P, Damsbo P, Gall MA, Richter EA, Beck-Nielsen H.
J Clin Invest. 1991 Oct;88(4):1282-90.PMID: 1918378 [PubMed - indexed for MEDLINE]Related articlesFree article
Tumor necrosis factor alpha is associated with insulin-mediated suppression of free fatty acids and net lipid oxidation in HIV-infected patients with lipodystrophy.
Haugaard SB, Andersen O, Pedersen SB, Dela F, Fenger M, Richelsen B, Madsbad S, Iversen J.
Metabolism. 2006 Feb;55(2):175-82.PMID: 16423623 [PubMed - indexed for MEDLINE]Related articles
Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.
Santomauro AT, Boden G, Silva ME, Rocha DM, Santos RF, Ursich MJ, Strassmann PG, Wajchenberg BL.
Diabetes. 1999 Sep;48(9):1836-41.PMID: 10480616 [PubMed - indexed for MEDLINE]Related articlesFree article
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.
Miyazaki Y, He H, Mandarino LJ, DeFronzo RA.
Diabetes. 2003 Aug;52(8):1943-50.PMID: 12882909 [PubMed - indexed for MEDLINE]Related articlesFree article
Physiologic growth hormone replacement improves fasting lipid kinetics in patients with HIV lipodystrophy syndrome.
D'Amico S, Shi J, Sekhar RV, Jahoor F, Ellis KJ, Rehman K, Willis J, Maldonado M, Balasubramanyam A.
Am J Clin Nutr. 2006 Jul;84(1):204-11.PMID: 16825697 [PubMed - indexed for MEDLINE]Related articlesFree article
Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells.
Haugaard SB, Andersen O, Dela F, Holst JJ, Storgaard H, Fenger M, Iversen J, Madsbad S.
Eur J Endocrinol. 2005 Jan;152(1):103-12.PMID: 15762193 [PubMed - indexed for MEDLINE]Related articlesFree article
Inhibition of the rise in FFA by Acipimox partially prevents GH-induced insulin resistance in GH-deficient adults.
J Clin Endocrinol Metab. 2001 Dec;86(12):5813-8.PMID: 11739444 [PubMed - indexed for MEDLINE]Related articlesFree article
Dose-response effects of free fatty acids on glucose and lipid metabolism during somatostatin blockade of growth hormone and insulin in humans.
Gormsen LC, Jessen N, Gjedsted J, Gjedde S, Nørrelund H, Lund S, Christiansen JS, Nielsen S, Schmitz O, Møller N.
J Clin Endocrinol Metab. 2007 May;92(5):1834-42. Epub 2007 Mar 6.PMID: 17341555 [PubMed - indexed for MEDLINE]Related articlesFree article
Lipodystrophy in HIV-1-positive patients is associated with insulin resistance in multiple metabolic pathways.
van der Valk M, Bisschop PH, Romijn JA, Ackermans MT, Lange JM, Endert E, Reiss P, Sauerwein HP.
AIDS. 2001 Nov 9;15(16):2093-100.PMID: 11684928 [PubMed - indexed for MEDLINE]Related articles
Pharmacological antilipolysis restores insulin sensitivity during growth hormone exposure.
Nielsen S, Møller N, Christiansen JS, Jørgensen JO.
Diabetes. 2001 Oct;50(10):2301-8.PMID: 11574412 [PubMed - indexed for MEDLINE]Related articlesFree article
Irreversibility of the defect in glycogen synthase activity in skeletal muscle from obese patients with NIDDM treated with diet and metformin.
Damsbo P, Hermann LS, Vaag A, Hother-Nielsen O, Beck-Nielsen H.
Diabetes Care. 1998 Sep;21(9):1489-94.PMID: 9727896 [PubMed - indexed for MEDLINE]Related articlesFree article
Lowering plasma free fatty acids with Acipimox mimics the antidiabetic effects of the beta 3-adrenergic agonist CL-316243 in obese Zucker diabetic fatty rats.
Blachère JC, Pérusse F, Bukowiecki LJ.
Metabolism. 2001 Aug;50(8):945-51.PMID: 11474483 [PubMed - indexed for MEDLINE]Related articles
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