PubMed

Physiological hyperinsulinemia has no detectable effect on access of macromolecules to insulin-sensitive tissues in healthy humans.

Weinhandl H, Pachler C, Mader JK, Ikeoka D, Mautner A, Falk A, Suppan M, Pieber TR, Ellmerer M.

Diabetes. 2007 Sep;56(9):2213-7. Epub 2007 Jun 29.PMID: 17601990 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological hyperinsulinemia in dogs augments access of macromolecules to insulin-sensitive tissues.

Ellmerer M, Kim SP, Hamilton-Wessler M, Hücking K, Kirkman E, Bergman RN.

Diabetes. 2004 Nov;53(11):2741-7.PMID: 15504953 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake.

Ellmerer M, Hamilton-Wessler M, Kim SP, Huecking K, Kirkman E, Chiu J, Richey J, Bergman RN.

Diabetes. 2006 Jun;55(6):1769-75.PMID: 16731841 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinemia rapidly increases human muscle microvascular perfusion but fails to increase muscle insulin clearance: evidence that a saturable process mediates muscle insulin uptake.

Eggleston EM, Jahn LA, Barrett EJ.

Diabetes. 2007 Dec;56(12):2958-63. Epub 2007 Aug 24.PMID: 17720897 [PubMed - indexed for MEDLINE]Related articlesFree article

Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.

Bodenlenz M, Schaupp LA, Druml T, Sommer R, Wutte A, Schaller HC, Sinner F, Wach P, Pieber TR.

Am J Physiol Endocrinol Metab. 2005 Aug;289(2):E296-300. Epub 2005 Mar 15.PMID: 15769794 [PubMed - indexed for MEDLINE]Related articlesFree article

Increase in systolic blood pressure and catecholamine level during hyperinsulinemia in a placebo-controlled euglycemic clamp in healthy subjects.

Kern W, Fittje A, Fohr W, Kerner W, Born J, Fehm HL.

Exp Clin Endocrinol Diabetes. 2000;108(8):498-505.PMID: 11149624 [PubMed - indexed for MEDLINE]Related articles

Mechanism of action in dogs of slow-acting insulin analog O346.

Ellmerer M, Hamilton-Wessler M, Kim SP, Dea MK, Kirkman E, Perianayagam A, Markussen J, Bergman RN.

J Clin Endocrinol Metab. 2003 May;88(5):2256-62.PMID: 12727983 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics.

Steil GM, Richey J, Kim JK, Wi JK, Rebrin K, Bergman RN, Youn JH.

Am J Physiol. 1996 Nov;271(5 Pt 1):E855-64.PMID: 8944672 [PubMed - indexed for MEDLINE]Related articles

Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects.

Sjöstrand M, Gudbjörnsdottir S, Holmäng A, Lönn L, Strindberg L, Lönnroth P.

Diabetes. 2002 Sep;51(9):2742-8.PMID: 12196467 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulates epinephrine release under euglycemic conditions in humans.

Tack CJ, Lenders JW, Willemsen JJ, van Druten JA, Thien T, Lutterman JA, Smits P.

Metabolism. 1998 Mar;47(3):243-9.PMID: 9500557 [PubMed - indexed for MEDLINE]Related articles

Mode of transcapillary transport of insulin and insulin analog NN304 in dog hindlimb: evidence for passive diffusion.

Hamilton-Wessler M, Ader M, Dea MK, Moore D, Loftager M, Markussen J, Bergman RN.

Diabetes. 2002 Mar;51(3):574-82.PMID: 11872653 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin on the distribution and disposition of glucose in man.

Ferrannini E, Smith JD, Cobelli C, Toffolo G, Pilo A, DeFronzo RA.

J Clin Invest. 1985 Jul;76(1):357-64.PMID: 3894421 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II induces insulin resistance independent of changes in interstitial insulin.

Richey JM, Ader M, Moore D, Bergman RN.

Am J Physiol. 1999 Nov;277(5 Pt 1):E920-6.PMID: 10567021 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.

Vincent MA, Dawson D, Clark AD, Lindner JR, Rattigan S, Clark MG, Barrett EJ.

Diabetes. 2002 Jan;51(1):42-8.PMID: 11756321 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased forearm blood flow during glucose clamp is related neither to insulin sensitivity nor to hyperinsulinemia in borderline hypertensive young men.

Høieggen A, Fossum E, Moan A, Rostrup M, Eide IK, Kjeldsen SE.

Blood Press. 1999;8(4):227-32.PMID: 10697303 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II increases glucose utilization during acute hyperinsulinemia via a hemodynamic mechanism.

Buchanan TA, Thawani H, Kades W, Modrall JG, Weaver FA, Laurel C, Poppiti R, Xiang A, Hsueh W.

J Clin Invest. 1993 Aug;92(2):720-6.PMID: 8349811 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of insulin on basal and cholecystokinin-stimulated gallbladder motility in humans.

Gielkens HA, Lam WF, Coenraad M, Frölich M, van Oostayen JA, Lamers CB, Masclee AA.

J Hepatol. 1998 Apr;28(4):595-602.PMID: 9566827 [PubMed - indexed for MEDLINE]Related articles

Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle.

Clerk LH, Vincent MA, Jahn LA, Liu Z, Lindner JR, Barrett EJ.

Diabetes. 2006 May;55(5):1436-42.PMID: 16644702 [PubMed - indexed for MEDLINE]Related articlesFree article

Dose-response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues.

Yang YJ, Hope I, Ader M, Poulin RA, Bergman RN.

Diabetes. 1992 Feb;41(2):241-53. Erratum in: Diabetes 1997 Apr;46(4):731. PMID: 1733816 [PubMed - indexed for MEDLINE]Related articles

Local methacholine but not bradykinin potentiates insulin-mediated glucose uptake in muscle in vivo by augmenting capillary recruitment.

Mahajan H, Richards SM, Rattigan S, Clark MG.

Diabetologia. 2004 Dec;47(12):2226-34. Epub 2004 Dec 16.PMID: 15602653 [PubMed - indexed for MEDLINE]Related articles