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    Results: 1 to 20 of 1984

    1.

    Normalization of prandial blood glucose and improvement of glucose tolerance by liver-specific inhibition of SH2 domain containing inositol phosphatase 2 (SHIP2) in diabetic KKAy mice: SHIP2 inhibition causes insulin-mimetic effects on glycogen metabolism, gluconeogenesis, and glycolysis.

    Grempler R, Zibrova D, Schoelch C, van Marle A, Rippmann JF, Redemann N.

    Diabetes. 2007 Sep;56(9):2235-41. Epub 2007 Jun 27.PMID: 17596404 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.

    Kagawa S, Soeda Y, Ishihara H, Oya T, Sasahara M, Yaguchi S, Oshita R, Wada T, Tsuneki H, Sasaoka T.

    Endocrinology. 2008 Feb;149(2):642-50. Epub 2007 Nov 26.PMID: 18039790 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5'-phosphatase 2) on insulin signaling and glucose metabolism in mice.

    Fukui K, Wada T, Kagawa S, Nagira K, Ikubo M, Ishihara H, Kobayashi M, Sasaoka T.

    Diabetes. 2005 Jul;54(7):1958-67.PMID: 15983195 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.

    Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.

    Mol Cell Biol. 2001 Mar;21(5):1633-46.PMID: 11238900 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    The lipid phosphatase SHIP2 controls insulin sensitivity.

    Clément S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S.

    Nature. 2001 Jan 4;409(6816):92-7. Erratum in: Nature. 2004 Oct 14;431(7010):878. PMID: 11343120 [PubMed - indexed for MEDLINE]Related articles

    6.

    SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.

    Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M.

    Diabetologia. 2001 Oct;44(10):1258-67.PMID: 11692174 [PubMed - indexed for MEDLINE]Related articles

    7.

    Inhibition of SH2-domain containing inositol phosphatase 2 (SHIP2) in insulin producing INS1E cells improves insulin signal transduction and induces proliferation.

    Grempler R, Leicht S, Kischel I, Eickelmann P, Redemann N.

    FEBS Lett. 2007 Dec 22;581(30):5885-90. Epub 2007 Dec 3.PMID: 18061583 [PubMed - indexed for MEDLINE]Related articles

    8.

    Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.

    Sasaoka T, Wada T, Tsuneki H.

    Pharmacol Ther. 2006 Dec;112(3):799-809. Epub 2006 Jul 13. Review.PMID: 16842857 [PubMed - indexed for MEDLINE]Related articles

    9.

    Perturbation of glucose flux in the liver by decreasing F26P2 levels causes hepatic insulin resistance and hyperglycemia.

    Wu C, Khan SA, Peng LJ, Li H, Carmella SG, Lange AJ.

    Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E536-43. Epub 2006 Apr 18. Erratum in: Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E370. PMID: 16621898 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.

    Ishihara H, Sasaoka T, Ishiki M, Wada T, Hori H, Kagawa S, Kobayashi M.

    Mol Endocrinol. 2002 Oct;16(10):2371-81.PMID: 12351701 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.

    Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M.

    J Biol Chem. 2004 Apr 9;279(15):14835-43. Epub 2004 Jan 26.PMID: 14744864 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Glucose metabolism in transgenic mice containing a chimeric P-enolpyruvate carboxykinase/bovine growth hormone gene.

    Valera A, Rodriguez-Gil JE, Yun JS, McGrane MM, Hanson RW, Bosch F.

    FASEB J. 1993 Jun;7(9):791-800.PMID: 8330686 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding.

    Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW.

    Diabetes. 1997 Nov;46(11):1768-74.PMID: 9356024 [PubMed - indexed for MEDLINE]Related articles

    14.

    Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome.

    Buettner R, Ottinger I, Gerhardt-Salbert C, Wrede CE, Schölmerich J, Bollheimer LC.

    Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1871-8. Epub 2007 Feb 27.PMID: 17327370 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats.

    Alemzadeh R, Holshouser S, Massey P, Koontz J.

    Eur J Endocrinol. 2002 Jun;146(6):871-9.PMID: 12039709 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade.

    Bertelli DF, Ueno M, Amaral ME, Toyama MH, Carneiro EM, Marangoni S, Carvalho CR, Saad MJ, Velloso LA, Boschero AC.

    Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E679-87. Epub 2002 Nov 26.PMID: 12453826 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Amelioration of glucose tolerance by hepatic inhibition of nuclear factor kappaB in db/db mice.

    Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T, Sato F, Hirose T, Tanaka Y, Mochizuki H, Kawamori R, Watada H.

    Diabetologia. 2007 Jan;50(1):131-41. Epub 2006 Nov 9.PMID: 17093946 [PubMed - indexed for MEDLINE]Related articles

    18.

    Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway.

    Burcelin R, del Carmen Muñoz M, Guillam MT, Thorens B.

    J Biol Chem. 2000 Apr 14;275(15):10930-6.PMID: 10753892 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice.

    Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y.

    Metabolism. 2007 Mar;56(3):420-9.PMID: 17292733 [PubMed - indexed for MEDLINE]Related articles

    20.

    Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats.

    Becker DJ, Reul B, Ozcelikay AT, Buchet JP, Henquin JC, Brichard SM.

    Diabetologia. 1996 Jan;39(1):3-11.PMID: 8720597 [PubMed - indexed for MEDLINE]Related articles

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