PubMed

Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction.

Hao M, Head WS, Gunawardana SC, Hasty AH, Piston DW.

Diabetes. 2007 Sep;56(9):2328-38. Epub 2007 Jun 15.PMID: 17575085 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice.

Nagasumi K, Esaki R, Iwachidow K, Yasuhara Y, Ogi K, Tanaka H, Nakata M, Yano T, Shimakawa K, Taketomi S, Takeuchi K, Odaka H, Kaisho Y.

Diabetes. 2009 May;58(5):1067-76. Erratum in: Diabetes. 2009 Jul;58(7):1721. PMID: 19401434 [PubMed - indexed for MEDLINE]Related articlesFree article

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction.

Kooptiwut S, Kebede M, Zraika S, Visinoni S, Aston-Mourney K, Favaloro J, Tikellis C, Thomas MC, Forbes JM, Cooper ME, Dunlop M, Proietto J, Andrikopoulos S.

J Mol Endocrinol. 2005 Aug;35(1):39-48.PMID: 16087720 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes.

Asghar Z, Yau D, Chan F, Leroith D, Chan CB, Wheeler MB.

Diabetologia. 2006 Jan;49(1):90-9. Epub 2005 Dec 15. Erratum in: Diabetologia. 2006 Mar;49(3):614. PMID: 16362284 [PubMed - indexed for MEDLINE]Related articles

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR.

Nat Med. 2007 Mar;13(3):340-7. Epub 2007 Feb 18.PMID: 17322896 [PubMed - indexed for MEDLINE]Related articles

Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test.

Festa A, Williams K, Hanley AJ, Haffner SM.

Diabetes. 2008 Jun;57(6):1638-44. Epub 2008 Mar 10.PMID: 18332099 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Beneficial effects of lipids and prolactin on insulin secretion and beta-cell proliferation: a role for lipids in the adaptation of islets to pregnancy.

Brelje TC, Bhagroo NV, Stout LE, Sorenson RL.

J Endocrinol. 2008 May;197(2):265-76.PMID: 18434356 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells.

Cantley J, Burchfield JG, Pearson GL, Schmitz-Peiffer C, Leitges M, Biden TJ.

Diabetes. 2009 Aug;58(8):1826-34. Epub 2009 Apr 28.PMID: 19401415 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of beta-cell function of pancreatic islets isolated from bank voles developing glucose intolerance/diabetes: an animal model showing features of both type 1 and type 2 diabetes mellitus, and a possible role of the Ljungan virus.

Blixt M, Niklasson B, Sandler S.

Gen Comp Endocrinol. 2007 Oct-Dec;154(1-3):41-7. Epub 2007 Jul 4.PMID: 17686482 [PubMed - indexed for MEDLINE]Related articles

Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

Kebede M, Favaloro J, Gunton JE, Laybutt DR, Shaw M, Wong N, Fam BC, Aston-Mourney K, Rantzau C, Zulli A, Proietto J, Andrikopoulos S.

Diabetes. 2008 Jul;57(7):1887-95. Epub 2008 Mar 28.PMID: 18375435 [PubMed - indexed for MEDLINE]Related articlesFree article

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity.

Ishikawa M, Iwasaki Y, Yatoh S, Kato T, Kumadaki S, Inoue N, Yamamoto T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Yamada N, Shimano H.

J Lipid Res. 2008 Dec;49(12):2524-34. Epub 2008 Aug 5.PMID: 18682608 [PubMed - indexed for MEDLINE]Related articlesFree article

Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells.

Yang J, Wong RK, Park M, Wu J, Cook JR, York DA, Deng S, Markmann J, Naji A, Wolf BA, Gao Z.

Diabetes. 2006 Jan;55(1):193-201.PMID: 16380493 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormalities in insulin secretion in type 2 diabetes mellitus.

Guillausseau PJ, Meas T, Virally M, Laloi-Michelin M, Médeau V, Kevorkian JP.

Diabetes Metab. 2008 Feb;34 Suppl 2:S43-8. Review.PMID: 18640585 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice.

Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, Ferrara N, Gerber H, Kawamori R, Inoue M, Watada H.

Diabetologia. 2007 Feb;50(2):380-9. Epub 2006 Dec 16.PMID: 17180351 [PubMed - indexed for MEDLINE]Related articles

Fatty acid signaling in the beta-cell and insulin secretion.

Nolan CJ, Madiraju MS, Delghingaro-Augusto V, Peyot ML, Prentki M.

Diabetes. 2006 Dec;55 Suppl 2:S16-23. Review.PMID: 17130640 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute and chronic effects of different concentrations of free fatty acids on the insulin secreting function of islets.

Ayvaz G, Balos Törüner F, Karakoç A, Yetkin I, Cakir N, Arslan M.

Diabetes Metab. 2002 Dec;28(6 Pt 2):3S7-12; discussion 3S108-12.PMID: 12688627 [PubMed - indexed for MEDLINE]Related articles

[New aspects of pancreatic beta cell functions and their possible therapeutic applications]

Tiedge M.

Dtsch Med Wochenschr. 2006 Dec;131 Suppl 8:S226-30. Review. German. PMID: 17139575 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice.

Sone H, Kagawa Y.

Diabetologia. 2005 Jan;48(1):58-67. Epub 2004 Dec 29.PMID: 15624098 [PubMed - indexed for MEDLINE]Related articles