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    Results: 1 to 20 of 860

    1.

    Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin.

    Dezaki K, Kakei M, Yada T.

    Diabetes. 2007 Sep;56(9):2319-27. Epub 2007 Jun 15.PMID: 17575083 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents.

    Dezaki K, Hosoda H, Kakei M, Hashiguchi S, Watanabe M, Kangawa K, Yada T.

    Diabetes. 2004 Dec;53(12):3142-51.PMID: 15561944 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways.

    Han XF, Zhu YL, Hernandez M, Keating DJ, Chen C.

    Endocrine. 2005 Nov;28(2):217-24.PMID: 16388096 [PubMed - indexed for MEDLINE]Related articles

    4.

    Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential.

    Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M.

    Curr Diabetes Rev. 2008 Feb;4(1):18-23. Review.PMID: 18220691 [PubMed - indexed for MEDLINE]Related articles

    5.

    Pertussis toxin-sensitive pathway inhibits glucose-stimulated Ca2+ signals of rat islet beta-cells by affecting L-type Ca2+ channels and voltage-dependent K+ channels.

    Suga S, Takeo T, Nakano K, Sato T, Igarashi T, Yamana D, Wakui M.

    Cell Calcium. 2004 Dec;36(6):469-77.PMID: 15488596 [PubMed - indexed for MEDLINE]Related articles

    6.

    Effects of caffeine on cytoplasmic free Ca2+ concentration in pancreatic beta-cells are mediated by interaction with ATP-sensitive K+ channels and L-type voltage-gated Ca2+ channels but not the ryanodine receptor.

    Islam MS, Larsson O, Nilsson T, Berggren PO.

    Biochem J. 1995 Mar 15;306 ( Pt 3):679-86.PMID: 7702559 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance.

    Dezaki K, Sone H, Koizumi M, Nakata M, Kakei M, Nagai H, Hosoda H, Kangawa K, Yada T.

    Diabetes. 2006 Dec;55(12):3486-93.PMID: 17130496 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.

    Braun M, Ramracheya R, Bengtsson M, Zhang Q, Karanauskaite J, Partridge C, Johnson PR, Rorsman P.

    Diabetes. 2008 Jun;57(6):1618-28. Epub 2008 Apr 4.PMID: 18390794 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.

    Düfer M, Gier B, Wolpers D, Krippeit-Drews P, Ruth P, Drews G.

    Diabetes. 2009 Aug;58(8):1835-43. Epub 2009 Apr 28.PMID: 19401418 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.

    Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S.

    Eur J Endocrinol. 2003 Oct;149(4):343-50.PMID: 14514350 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Oleic acid interacts with GPR40 to induce Ca2+ signaling in rat islet beta-cells: mediation by PLC and L-type Ca2+ channel and link to insulin release.

    Fujiwara K, Maekawa F, Yada T.

    Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E670-7. Epub 2005 May 24.PMID: 15914509 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

    MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, Sakellaropoulos G, Wang J, Saleh MC, Chan CB, Tsushima RG, Salapatek AM, Wheeler MB.

    J Biol Chem. 2002 Nov 22;277(47):44938-45. Epub 2002 Sep 20.PMID: 12270920 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids.

    Feng DD, Luo Z, Roh SG, Hernandez M, Tawadros N, Keating DJ, Chen C.

    Endocrinology. 2006 Feb;147(2):674-82. Epub 2005 Oct 27.PMID: 16254037 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Neuropeptide W in the rat pancreas: potentiation of glucose-induced insulin release and Ca2+ influx through L-type Ca2+ channels in beta-cells and localization in islets.

    Dezaki K, Kageyama H, Seki M, Shioda S, Yada T.

    Regul Pept. 2008 Jan 10;145(1-3):153-8. Epub 2007 Aug 24.PMID: 17868932 [PubMed - indexed for MEDLINE]Related articles

    15.

    HIV protease inhibitors: suppression of insulin secretion by inhibition of voltage-dependent K+ currents and anion currents.

    Neye Y, Düfer M, Drews G, Krippeit-Drews P.

    J Pharmacol Exp Ther. 2006 Jan;316(1):106-12. Epub 2005 Sep 14.PMID: 16162820 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Crosstalk between membrane potential and cytosolic Ca2+ concentration in beta cells from Sur1-/- mice.

    Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G, Düfer M.

    Diabetologia. 2005 May;48(5):913-21. Epub 2005 Apr 14.PMID: 15830184 [PubMed - indexed for MEDLINE]Related articles

    17.

    Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

    Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J.

    J Pharmacol Exp Ther. 2007 Aug;322(2):871-8. Epub 2007 May 23.PMID: 17522344 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.

    Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F, Destefanis S, Annunziata M, Martinetti M, Catapano F, Ghè C, Isgaard J, Papotti M, Ghigo E, Muccioli G.

    Endocrinology. 2007 Feb;148(2):512-29. Epub 2006 Oct 26.PMID: 17068144 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Glucose stimulates Ca2+ influx and insulin secretion in 2-week-old beta-cells lacking ATP-sensitive K+ channels.

    Szollosi A, Nenquin M, Aguilar-Bryan L, Bryan J, Henquin JC.

    J Biol Chem. 2007 Jan 19;282(3):1747-56. Epub 2006 Nov 30.PMID: 17138557 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis.

    Dezaki K, Sone H, Yada T.

    Pharmacol Ther. 2008 May;118(2):239-49. Epub 2008 Mar 10. Review.PMID: 18433874 [PubMed - indexed for MEDLINE]Related articles

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