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    Results: 1 to 20 of 212

    1.

    Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.

    Croce MA, Eagon JC, LaRiviere LL, Korenblat KM, Klein S, Finck BN.

    Diabetes. 2007 Sep;56(9):2395-9. Epub 2007 Jun 11.PMID: 17563064 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

    Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr, Kelly DP.

    Cell Metab. 2006 Sep;4(3):199-210.PMID: 16950137 [PubMed - indexed for MEDLINE]Related articles

    3.

    Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.

    Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM.

    Diabetes. 2009 Jul;58(7):1499-508. Epub 2009 Apr 14.PMID: 19366863 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome.

    Mlinar B, Pfeifer M, Vrtacnik-Bokal E, Jensterle M, Marc J.

    Eur J Endocrinol. 2008 Dec;159(6):833-9. Epub 2008 Oct 1.PMID: 18829900 [PubMed - indexed for MEDLINE]Related articles

    5.

    Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation.

    Yao-Borengasser A, Rasouli N, Varma V, Miles LM, Phanavanh B, Starks TN, Phan J, Spencer HJ 3rd, McGehee RE Jr, Reue K, Kern PA.

    Diabetes. 2006 Oct;55(10):2811-8.PMID: 17003347 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.

    Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF.

    Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E945-54. Epub 2009 Feb 10.PMID: 19208857 [PubMed - indexed for MEDLINE]Related articles

    7.

    Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.

    Donkor J, Sparks LM, Xie H, Smith SR, Reue K.

    J Clin Endocrinol Metab. 2008 Jan;93(1):233-9. Epub 2007 Oct 9.PMID: 17925338 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

    Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

    J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.PMID: 17416903 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    PGC-1beta in the regulation of hepatic glucose and energy metabolism.

    Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM.

    J Biol Chem. 2003 Aug 15;278(33):30843-8. Epub 2003 Jun 13.PMID: 12807885 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.

    van Harmelen V, Rydén M, Sjölin E, Hoffstedt J.

    J Lipid Res. 2007 Jan;48(1):201-6. Epub 2006 Oct 11.PMID: 17035674 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.

    Fanelli M, Filippi E, Sentinelli F, Romeo S, Fallarino M, Buzzetti R, Leonetti F, Baroni MG.

    Dis Markers. 2005;21(4):175-80.PMID: 16403952 [PubMed - indexed for MEDLINE]Related articles

    12.

    Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene (PGC1A) during weight loss is related to insulin sensitivity but not to energy expenditure.

    Gastaldi G, Russell A, Golay A, Giacobino JP, Habicht F, Barthassat V, Muzzin P, Bobbioni-Harsch E.

    Diabetologia. 2007 Nov;50(11):2348-55. Epub 2007 Sep 8.PMID: 17828388 [PubMed - indexed for MEDLINE]Related articles

    13.

    Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.

    Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM.

    J Biol Chem. 2002 Jan 18;277(3):1645-8. Epub 2001 Nov 30.PMID: 11733490 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    The role of lipin 1 in adipogenesis and lipid metabolism.

    Reue K.

    Novartis Found Symp. 2007;286:58-68; discussion 68-71, 162-3, 196-203.PMID: 18269174 [PubMed - indexed for MEDLINE]Related articles

    15.

    Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice.

    De Souza CT, Araújo EP, Prada PO, Saad MJ, Boschero AC, Velloso LA.

    Diabetologia. 2005 Sep;48(9):1860-71. Epub 2005 Jul 16.PMID: 16025253 [PubMed - indexed for MEDLINE]Related articles

    16.

    Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway.

    Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP.

    Circulation. 2007 Feb 20;115(7):909-17. Epub 2007 Jan 29.PMID: 17261654 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

    Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

    PLoS Biol. 2006 Nov;4(11):e369.PMID: 17090215 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.

    Chen Z, Gropler MC, Norris J, Lawrence JC Jr, Harris TE, Finck BN.

    Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1738-44. Epub 2008 Jul 31.PMID: 18669885 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.

    De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ.

    Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E607-14. Epub 2008 Jan 8.PMID: 18182465 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.

    Ponugoti B, Fang S, Kemper JK.

    Mol Endocrinol. 2007 Nov;21(11):2698-712. Epub 2007 Jul 17.PMID: 17636037 [PubMed - indexed for MEDLINE]Related articlesFree article

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