PubMed

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells.

Logie L, Ruiz-Alcaraz AJ, Keane M, Woods YL, Bain J, Marquez R, Alessi DR, Sutherland C.

Diabetes. 2007 Sep;56(9):2218-27. Epub 2007 Jun 11.PMID: 17563061 [PubMed - indexed for MEDLINE]Related articlesFree article

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.

Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS.

J Biol Chem. 2008 Oct 10;283(41):27653-67. Epub 2008 Jul 31.PMID: 18669636 [PubMed - indexed for MEDLINE]Related articlesFree article

Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein kinase B/Akt in muscles of obese diabetic humans.

Casaubon L, Sajan MP, Rivas J, Powe JL, Standaert ML, Farese RV.

Diabetologia. 2006 Dec;49(12):3000-8. Epub 2006 Oct 7.PMID: 17028898 [PubMed - indexed for MEDLINE]Related articles

The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB.

Hunter RW, Harper MT, Hers I.

J Thromb Haemost. 2008 Nov;6(11):1923-32. Epub 2008 Aug 28.PMID: 18761726 [PubMed - indexed for MEDLINE]Related articles

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

Lipina C, Huang X, Finlay D, McManus EJ, Alessi DR, Sutherland C.

Biochem J. 2005 Dec 15;392(Pt 3):633-9.PMID: 16176184 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a).

Orth HM, Krüger KD, Schmoll D, Grempler R, Scherbaum WA, Joost HG, Bornstein SR, Barthel A.

Regul Pept. 2004 Sep 15;121(1-3):19-24.PMID: 15256269 [PubMed - indexed for MEDLINE]Related articles

Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.

Xu H, Yang Q, Shen M, Huang X, Dembski M, Gimeno R, Tartaglia LA, Kapeller R, Wu Z.

J Biol Chem. 2005 Oct 28;280(43):36013-8. Epub 2005 Aug 26.PMID: 16126724 [PubMed - indexed for MEDLINE]Related articlesFree article

The involvement of phosphatidylinositol 3-kinase in gonadotropin-releasing hormone-induced gonadotropin alpha- and FSHbeta-subunit genes expression in clonal gonadotroph LbetaT2 cells.

Mutiara S, Kanasaki H, Harada T, Oride A, Miyazaki K.

Mol Cell Endocrinol. 2008 Feb 13;283(1-2):1-11. Epub 2007 Dec 8.PMID: 18206295 [PubMed - indexed for MEDLINE]Related articles

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.

Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR.

Biochem J. 2005 Feb 1;385(Pt 3):639-48.PMID: 15554902 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulates the expression of several metabolism-related genes in the liver and primary hepatocytes of rainbow trout (Oncorhynchus mykiss).

Plagnes-Juan E, Lansard M, Seiliez I, Médale F, Corraze G, Kaushik S, Panserat S, Skiba-Cassy S.

J Exp Biol. 2008 Aug;211(Pt 15):2510-8.PMID: 18626086 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio.

Shao J, Qiao L, Janssen RC, Pagliassotti M, Friedman JE.

Diabetes. 2005 Apr;54(4):976-84.PMID: 15793235 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin regulation of PEPCK gene expression: a model for rapid and reversible modulation.

Quinn PG, Yeagley D.

Curr Drug Targets Immune Endocr Metabol Disord. 2005 Dec;5(4):423-37. Review.PMID: 16375695 [PubMed - indexed for MEDLINE]Related articles

IGF-1 protects against dexamethasone-induced cell death in insulin secreting INS-1 cells independent of AKT/PKB phosphorylation.

Avram D, Ranta F, Hennige AM, Berchtold S, Hopp S, Häring HU, Lang F, Ullrich S.

Cell Physiol Biochem. 2008;21(5-6):455-62. Epub 2008 Apr 24.PMID: 18453753 [PubMed - indexed for MEDLINE]Related articles

Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line.

Govorko D, Logendra S, Wang Y, Esposito D, Komarnytsky S, Ribnicky D, Poulev A, Wang Z, Cefalu WT, Raskin I.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1503-10. Epub 2007 Sep 11.PMID: 17848630 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.

Liu HK, Perrier S, Lipina C, Finlay D, McLauchlan H, Hastie CJ, Hundal HS, Sutherland C.

BMC Mol Biol. 2006 Apr 6;7:14.PMID: 16600022 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats.

Xu JT, Tu HY, Xin WJ, Liu XG, Zhang GH, Zhai CH.

Exp Neurol. 2007 Aug;206(2):269-79. Epub 2007 Jun 14.PMID: 17628541 [PubMed - indexed for MEDLINE]Related articles

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.

Cozzone D, Fröjdö S, Disse E, Debard C, Laville M, Pirola L, Vidal H.

Diabetologia. 2008 Mar;51(3):512-21. Epub 2008 Jan 18.PMID: 18204829 [PubMed - indexed for MEDLINE]Related articles

Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes.

Kitazawa M, Ohizumi Y, Oike Y, Hishinuma T, Hashimoto S.

J Pharmacol Exp Ther. 2007 Dec;323(3):787-93. Epub 2007 Sep 5.PMID: 17804676 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability.

Barry RE, Allan BB, Cummins EP, Kattla JJ, Giblin A, Scally N, Taylor CT, Brazil DP.

Eur J Cell Biol. 2007 Jul;86(7):393-403. Epub 2007 Jun 4.PMID: 17544543 [PubMed - indexed for MEDLINE]Related articles

Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure.

González M, Böer U, Dickel C, Quentin T, Cierny I, Oetjen E, Knepel W.

Diabetologia. 2008 Nov;51(11):2012-21. Epub 2008 Sep 2.PMID: 18762908 [PubMed - indexed for MEDLINE]Related articles