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Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome.

Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H, Højlund K.

Diabetes. 2007 Sep;56(9):2349-55. Epub 2007 Jun 11.PMID: 17563058 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome.

Skov V, Glintborg D, Knudsen S, Tan Q, Jensen T, Kruse TA, Beck-Nielsen H, Højlund K.

PLoS One. 2008 Jun 18;3(6):e2466.PMID: 18560589 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Højlund K, Glintborg D, Andersen NR, Birk JB, Treebak JT, Frøsig C, Beck-Nielsen H, Wojtaszewski JF.

Diabetes. 2008 Feb;57(2):357-66. Epub 2007 Oct 31.PMID: 17977950 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional profiling of myotubes from patients with type 2 diabetes: no evidence for a primary defect in oxidative phosphorylation genes.

Frederiksen CM, Højlund K, Hansen L, Oakeley EJ, Hemmings B, Abdallah BM, Brusgaard K, Beck-Nielsen H, Gaster M.

Diabetologia. 2008 Nov;51(11):2068-77. Epub 2008 Aug 22.PMID: 18719883 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance in skeletal muscle and adipose tissue in polycystic ovary syndrome: are the molecular mechanisms distinct from type 2 diabetes?

Corbould A.

Panminerva Med. 2008 Dec;50(4):279-94. Review.PMID: 19078869 [PubMed - indexed for MEDLINE]Related articles

[Genetic aspects of polycystic ovary syndrome]

Jakubowski L.

Endokrynol Pol. 2005 May-Jun;56(3):285-93. Review. Polish. PMID: 16350721 [PubMed - indexed for MEDLINE]Related articles

Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.

De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E607-14. Epub 2008 Jan 8.PMID: 18182465 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.

Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71. Epub 2003 Jun 27.PMID: 12832613 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.

Richardson DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA, Jenkinson CP, Mandarino LJ.

J Biol Chem. 2005 Mar 18;280(11):10290-7. Epub 2004 Dec 14.PMID: 15598661 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity.

San Millán JL, Cortón M, Villuendas G, Sancho J, Peral B, Escobar-Morreale HF.

J Clin Endocrinol Metab. 2004 Jun;89(6):2640-6.PMID: 15181035 [PubMed - indexed for MEDLINE]Related articlesFree article

Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose.

Tan BK, Adya R, Farhatullah S, Lewandowski KC, O'Hare P, Lehnert H, Randeva HS.

Diabetes. 2008 Apr;57(4):801-8. Epub 2008 Jan 3.PMID: 18174521 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.PMID: 17416903 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired insulin activation and dephosphorylation of glycogen synthase in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.

Glintborg D, Højlund K, Andersen NR, Hansen BF, Beck-Nielsen H, Wojtaszewski JF.

J Clin Endocrinol Metab. 2008 Sep;93(9):3618-26. Epub 2008 Jun 10.PMID: 18544618 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 2 diabetes and the polycystic ovary syndrome.

Pelusi B, Gambineri A, Pasquali R.

Minerva Ginecol. 2004 Feb;56(1):41-51. Review.PMID: 14973409 [PubMed - indexed for MEDLINE]Related articles

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ.

Diabetes. 2007 Aug;56(8):2085-92. Epub 2007 May 22.PMID: 17519422 [PubMed - indexed for MEDLINE]Related articlesFree article

Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma gene in first-degree relatives of subjects with polycystic ovary syndrome.

Yilmaz M, Ergün MA, Karakoç A, Yurtçu E, Yetkin I, Ayvaz G, Cakir N, Arslan M.

Gynecol Endocrinol. 2005 Oct;21(4):206-10.PMID: 16316841 [PubMed - indexed for MEDLINE]Related articles

Insulin sensitivity, insulin secretion, and metabolic and hormonal parameters in healthy women and women with polycystic ovarian syndrome.

Morin-Papunen LC, Vauhkonen I, Koivunen RM, Ruokonen A, Tapanainen JS.

Hum Reprod. 2000 Jun;15(6):1266-74.PMID: 10831553 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?

Patti ME.

Curr Opin Clin Nutr Metab Care. 2004 Jul;7(4):383-90. Review.PMID: 15192439 [PubMed - indexed for MEDLINE]Related articles

Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance.

Ciaraldi TP, Aroda V, Mudaliar S, Chang RJ, Henry RR.

J Clin Endocrinol Metab. 2009 Jan;94(1):157-63. Epub 2008 Oct 14.PMID: 18854391 [PubMed - indexed for MEDLINE]Related articles

Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients.

Debard C, Laville M, Berbe V, Loizon E, Guillet C, Morio-Liondore B, Boirie Y, Vidal H.

Diabetologia. 2004 May;47(5):917-25. Epub 2004 May 1.PMID: 15127202 [PubMed - indexed for MEDLINE]Related articles