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    Results: 1 to 20 of 104

    1.

    Selective cytotoxicity of pancratistatin-related natural Amaryllidaceae alkaloids: evaluation of the activity of two new compounds.

    Griffin C, Sharda N, Sood D, Nair J, McNulty J, Pandey S.

    Cancer Cell Int. 2007 Jun 5;7:10.PMID: 17550595 [PubMed]Related articlesFree article

    2.

    Induction of apoptotic cell death specifically in rat and human cancer cells by pancratistatin.

    Pandey S, Kekre N, Naderi J, McNulty J.

    Artif Cells Blood Substit Immobil Biotechnol. 2005;33(3):279-95.PMID: 16152693 [PubMed - indexed for MEDLINE]Related articles

    3.

    Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis.

    McLachlan A, Kekre N, McNulty J, Pandey S.

    Apoptosis. 2005 May;10(3):619-30.PMID: 15909123 [PubMed - indexed for MEDLINE]Related articles

    4.

    Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids.

    McNulty J, Nair JJ, Singh M, Crankshaw DJ, Holloway AC, Bastida J.

    Bioorg Med Chem Lett. 2009 Jun 15;19(12):3233-7. Epub 2009 Apr 24.PMID: 19428250 [PubMed - indexed for MEDLINE]Related articles

    5.

    Synergy of Pancratistatin and Tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria.

    Siedlakowski P, McLachlan-Burgess A, Griffin C, Tirumalai SS, McNulty J, Pandey S.

    Cancer Biol Ther. 2008 Mar;7(3):376-84. Epub 2007 Dec 2.PMID: 18075307 [PubMed - indexed for MEDLINE]Related articles

    6.

    Synthesis and biological evaluation of aromatic analogues of conduritol F, L-chiro-inositol, and dihydroconduritol F structurally related to the amaryllidaceae anticancer constituents.

    Kireev AS, Nadein ON, Agustin VJ, Bush NE, Evidente A, Manpadi M, Ogasawara MA, Rastogi SK, Rogelj S, Shors ST, Kornienko A.

    J Org Chem. 2006 Jul 21;71(15):5694-707.PMID: 16839151 [PubMed - indexed for MEDLINE]Related articles

    7.

    A synthesis of 3-deoxydihydrolycoricidine: refinement of a structurally minimum pancratistatin pharmacophore.

    McNulty J, Larichev V, Pandey S.

    Bioorg Med Chem Lett. 2005 Dec 1;15(23):5315-8. Epub 2005 Sep 23.PMID: 16183280 [PubMed - indexed for MEDLINE]Related articles

    8.

    Synthesis of structurally simplified analogues of pancratistatin: truncation of the cyclitol ring.

    Manpadi M, Kireev AS, Magedov IV, Altig J, Tongwa P, Antipin MY, Evidente A, van Otterlo WA, Kornienko A.

    J Org Chem. 2009 Sep 18;74(18):7122-31.PMID: 19743883 [PubMed - indexed for MEDLINE]Related articles

    9.

    Structure activity studies on the crinane alkaloid apoptosis-inducing pharmacophore.

    McNulty J, Nair JJ, Bastida J, Pandey S, Griffin C.

    Nat Prod Commun. 2009 Apr;4(4):483-8.PMID: 19475990 [PubMed - indexed for MEDLINE]Related articles

    10.

    Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells.

    McNulty J, Nair JJ, Bastida J, Pandey S, Griffin C.

    Phytochemistry. 2009 May;70(7):913-9. Epub 2009 May 20.PMID: 19464034 [PubMed - indexed for MEDLINE]Related articles

    11.

    synthesis and biological evaluation of fully functionalized seco-pancratistatin analogues.

    McNulty J, Nair JJ, Griffin C, Pandey S.

    J Nat Prod. 2008 Mar;71(3):357-63. Epub 2008 Jan 29.PMID: 18225861 [PubMed - indexed for MEDLINE]Related articles

    12.

    Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids.

    McNulty J, Nair JJ, Codina C, Bastida J, Pandey S, Gerasimoff J, Griffin C.

    Phytochemistry. 2007 Apr;68(7):1068-74. Epub 2007 Feb 28.PMID: 17331551 [PubMed - indexed for MEDLINE]Related articles

    13.

    Sodium pancratistatin 3,4-o-cyclic phosphate, a water-soluble synthetic derivative of pancratistatin, is highly effective in a human colon tumor model.

    Shnyder SD, Cooper PA, Millington NJ, Gill JH, Bibby MC.

    J Nat Prod. 2008 Mar;71(3):321-4. Epub 2007 Dec 22.PMID: 18154271 [PubMed - indexed for MEDLINE]Related articles

    14.

    Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells.

    Griffin C, Hamm C, McNulty J, Pandey S.

    Cancer Cell Int. 2010 Mar 6;10(1):6. [Epub ahead of print]PMID: 20205924 [PubMed - as supplied by publisher]Related articlesFree article

    15.

    Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

    Donnelly A, Blagg BS.

    Curr Med Chem. 2008;15(26):2702-17. Review.PMID: 18991631 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy.

    de Fátima A, Zambuzzi WF, Modolo LV, Tarsitano CA, Gadelha FR, Hyslop S, de Carvalho JE, Salgado I, Ferreira CV, Pilli RA.

    Chem Biol Interact. 2008 Nov 25;176(2-3):143-50. Epub 2008 Aug 14.PMID: 18771661 [PubMed - indexed for MEDLINE]Related articles

    17.

    Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.

    Lamoral-Theys D, Andolfi A, Van Goietsenoven G, Cimmino A, Le Calvé B, Wauthoz N, Mégalizzi V, Gras T, Bruyère C, Dubois J, Mathieu V, Kornienko A, Kiss R, Evidente A.

    J Med Chem. 2009 Oct 22;52(20):6244-56.PMID: 19788245 [PubMed - indexed for MEDLINE]Related articles

    18.

    Biological evaluation of structurally diverse amaryllidaceae alkaloids and their synthetic derivatives: discovery of novel leads for anticancer drug design.

    Evidente A, Kireev AS, Jenkins AR, Romero AE, Steelant WF, Van Slambrouck S, Kornienko A.

    Planta Med. 2009 Apr;75(5):501-7. Epub 2009 Feb 23.PMID: 19235683 [PubMed - indexed for MEDLINE]Related articles

    19.

    Synthesis and structure-activity relationships of ferrocenyl tamoxifen derivatives with modified side chains.

    Nguyen A, Top S, Pigeon P, Vessières A, Hillard EA, Plamont MA, Huché M, Rigamonti C, Jaouen G.

    Chemistry. 2009;15(3):684-96.PMID: 19053086 [PubMed - indexed for MEDLINE]Related articles

    20.

    Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.

    McKee ML, Kerwin SM.

    Bioorg Med Chem. 2008 Feb 15;16(4):1775-83. Epub 2007 Nov 12.PMID: 18037301 [PubMed - indexed for MEDLINE]Related articlesFree article

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