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Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses.

Luque-Ramírez M, Alvarez-Blasco F, Botella-Carretero JI, Sanchón R, San Millán JL, Escobar-Morreale HF.

Diabetes Care. 2007 Sep;30(9):2309-13. Epub 2007 May 29.PMID: 17536071 [PubMed - indexed for MEDLINE]Related articlesFree article

Endocrine and metabolic effects of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome: a randomized study.

Morin-Papunen LC, Vauhkonen I, Koivunen RM, Ruokonen A, Martikainen HK, Tapanainen JS.

J Clin Endocrinol Metab. 2000 Sep;85(9):3161-8.PMID: 10999803 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome.

Luque-Ramírez M, Alvarez-Blasco F, Botella-Carretero JI, Martínez-Bermejo E, Lasunción MA, Escobar-Morreale HF.

J Clin Endocrinol Metab. 2007 Jul;92(7):2453-61. Epub 2007 Apr 10.PMID: 17426085 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study.

Morin-Papunen L, Vauhkonen I, Koivunen R, Ruokonen A, Martikainen H, Tapanainen JS.

J Clin Endocrinol Metab. 2003 Jan;88(1):148-56.PMID: 12519844 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin.

Luque-Ramírez M, Alvarez-Blasco F, Uriol Rivera MG, Escobar-Morreale HF.

Hum Reprod. 2008 Jul;23(7):1594-601. Epub 2008 Mar 27.PMID: 18375410 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of metformin and ethinyl estradiol-cyproterone acetate on clinical, endocrine and metabolic factors in women with polycystic ovary syndrome.

Wu J, Zhu Y, Jiang Y, Cao Y.

Gynecol Endocrinol. 2008 Jul;24(7):392-8.PMID: 18608522 [PubMed - indexed for MEDLINE]Related articles

Effects of an antiandrogenic oral contraceptive pill compared with metformin on blood coagulation tests and endothelial function in women with the polycystic ovary syndrome: influence of obesity and smoking.

Luque-Ramírez M, Mendieta-Azcona C, del Rey Sánchez JM, Matíes M, Escobar-Morreale HF.

Eur J Endocrinol. 2009 Mar;160(3):469-80. Epub 2009 Jan 12.PMID: 19139031 [PubMed - indexed for MEDLINE]Related articles

Effects of metformin versus ethinyl-estradiol plus cyproterone acetate on ambulatory blood pressure monitoring and carotid intima media thickness in women with the polycystic ovary syndrome.

Luque-Ramírez M, Mendieta-Azcona C, Alvarez-Blasco F, Escobar-Morreale HF.

Fertil Steril. 2009 Jun;91(6):2527-36. Epub 2008 Jun 18.PMID: 18565522 [PubMed - indexed for MEDLINE]Related articles

Antiandrogenic contraceptives increase serum adiponectin in obese polycystic ovary syndrome patients.

Luque-Ramírez M, Alvarez-Blasco F, Escobar-Morreale HF.

Obesity (Silver Spring). 2009 Jan;17(1):3-9. Epub 2008 Nov 6.PMID: 18997670 [PubMed - indexed for MEDLINE]Related articles

Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome.

Rautio K, Tapanainen JS, Ruokonen A, Morin-Papunen LC.

Eur J Endocrinol. 2005 Feb;152(2):269-75.PMID: 15745936 [PubMed - indexed for MEDLINE]Related articlesFree article

[Effect of 6-month treatment with oral antiandrogen alone and in combination with insulin sensitizers on body composition, hormonal and metabolic parameters in women with polycystic ovary syndrome (PCOS) in order to determine therapeutic strategy]

Orbetsova M, Kamenov Z, Kolarov G, Zakharieva S, Khristov V, Atanasova I, Shigarminova R, Milcheva B, Genchev G.

Akush Ginekol (Sofiia). 2006;45(7):16-28. Bulgarian. PMID: 17489164 [PubMed - indexed for MEDLINE]Related articles

Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study.

Elter K, Imir G, Durmusoglu F.

Hum Reprod. 2002 Jul;17(7):1729-37.PMID: 12093831 [PubMed - indexed for MEDLINE]Related articlesFree article

Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia.

Genazzani AD, Lanzoni C, Ricchieri F, Baraldi E, Casarosa E, Jasonni VM.

Gynecol Endocrinol. 2007 Mar;23(3):146-52.PMID: 17454168 [PubMed - indexed for MEDLINE]Related articles

Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome.

Morin-Papunen L, Rautio K, Ruokonen A, Hedberg P, Puukka M, Tapanainen JS.

J Clin Endocrinol Metab. 2003 Oct;88(10):4649-54.PMID: 14557435 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinol-binding protein 4 and insulin resistance in polycystic ovary syndrome.

Hutchison SK, Harrison C, Stepto N, Meyer C, Teede HJ.

Diabetes Care. 2008 Jul;31(7):1427-32. Epub 2008 Apr 4.PMID: 18390799 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome.

Yilmaz M, Biri A, Karakoç A, Törüner F, Bingöl B, Cakir N, Tiras B, Ayvaz G, Arslan M.

J Endocrinol Invest. 2005 Dec;28(11):1003-8.PMID: 16483179 [PubMed - indexed for MEDLINE]Related articles

Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity.

Ibáñez L, de Zegher F.

J Clin Endocrinol Metab. 2004 Apr;89(4):1592-7.PMID: 15070917 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of metformin on insulin resistance and ovarian steroidogenesis in women with polycystic ovary syndrome.

Unlühizarci K, Keleştimur F, Bayram F, Sahin Y, Tutuş A.

Clin Endocrinol (Oxf). 1999 Aug;51(2):231-6.PMID: 10468995 [PubMed - indexed for MEDLINE]Related articles

Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome.

Gambineri A, Pelusi C, Genghini S, Morselli-Labate AM, Cacciari M, Pagotto U, Pasquali R.

Clin Endocrinol (Oxf). 2004 Feb;60(2):241-9.PMID: 14725687 [PubMed - indexed for MEDLINE]Related articles

The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review.

Jing Z, Liang-Zhi X, Tai-Xiang W, Ying T, Yu-Jian J.

Gynecol Endocrinol. 2008 Oct;24(10):590-600. Review.PMID: 19012104 [PubMed - indexed for MEDLINE]Related articles