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    Results: 1 to 20 of 424

    1.

    Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

    Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ.

    Diabetes. 2007 Aug;56(8):1986-98. Epub 2007 May 22.PMID: 17519423 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet.

    Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, Knauf C, Peiretti F, Verdier M, Juhan-Vague I, Tanti JF, Burcelin R, Alessi MC.

    Diabetologia. 2007 Jun;50(6):1267-76. Epub 2007 Apr 11.PMID: 17426960 [PubMed - indexed for MEDLINE]Related articles

    3.

    Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

    Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW.

    Circ Res. 2007 Jun 8;100(11):1589-96. Epub 2007 May 3.PMID: 17478729 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.

    Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J.

    Mol Endocrinol. 2004 Aug;18(8):2024-34. Epub 2004 May 13.PMID: 15143153 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    TLR4 links innate immunity and fatty acid-induced insulin resistance.

    Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS.

    J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.PMID: 17053832 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

    Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME.

    Obesity (Silver Spring). 2008 Jun;16(6):1248-55. Epub 2008 Apr 10.PMID: 18421279 [PubMed - indexed for MEDLINE]Related articles

    7.

    Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion.

    Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Höer NF, Boschero AC, Saad MJ.

    Endocrinology. 2005 Mar;146(3):1576-87. Epub 2004 Dec 9.PMID: 15591151 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Pharmacological characterization of a small molecule inhibitor of c-Jun kinase.

    Cho H, Black SC, Looper D, Shi M, Kelly-Sullivan D, Timofeevski S, Siegel K, Yu XH, McDonnell SR, Chen P, Yie J, Ogilvie KM, Fraser J, Briscoe CP.

    Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1142-51. Epub 2008 Aug 26.PMID: 18728225 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

    Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA.

    J Neurosci. 2009 Jan 14;29(2):359-70.PMID: 19144836 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Low salt intake modulates insulin signaling, JNK activity and IRS-1ser307 phosphorylation in rat tissues.

    Prada PO, Coelho MS, Zecchin HG, Dolnikoff MS, Gasparetti AL, Furukawa LN, Saad MJ, Heimann JC.

    J Endocrinol. 2005 Jun;185(3):429-37.PMID: 15930169 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

    Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR.

    Diabetes. 2008 Jan;57(1):77-85. Epub 2007 Oct 10.PMID: 17928396 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.

    Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G.

    Nature. 2004 Sep 9;431(7005):200-5. Epub 2004 Aug 11. Erratum in: Nature. 2004 Sep 23;431(7007):485. PMID: 15306821 [PubMed - indexed for MEDLINE]Related articles

    13.

    Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

    Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW.

    Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1982-8. Epub 2008 Sep 4.PMID: 18772497 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.

    Liu LF, Purushotham A, Wendel AA, Belury MA.

    Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1671-82. Epub 2007 Feb 22.PMID: 17322064 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    A central role for JNK in obesity and insulin resistance.

    Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS.

    Nature. 2002 Nov 21;420(6913):333-6.PMID: 12447443 [PubMed - indexed for MEDLINE]Related articles

    16.

    Changes in adiponectin and inflammatory genes in response to hormonal imbalances in female mice and exacerbation of depot selective visceral adiposity by high-fat diet: implications for insulin resistance.

    Zhang H, Chen X, Aravindakshan J, Sairam MR.

    Endocrinology. 2007 Dec;148(12):5667-79. Epub 2007 Aug 23.PMID: 17717050 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.

    Prada PO, Hirabara SM, de Souza CT, Schenka AA, Zecchin HG, Vassallo J, Velloso LA, Carneiro E, Carvalheira JB, Curi R, Saad MJ.

    Diabetologia. 2007 Sep;50(9):1949-59. Epub 2007 Jun 29.PMID: 17604977 [PubMed - indexed for MEDLINE]Related articles

    18.

    Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice.

    Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y.

    Endocrinology. 2007 Oct;148(10):4548-56. Epub 2007 Jun 21.PMID: 17584959 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity.

    Samane S, Christon R, Dombrowski L, Turcotte S, Charrouf Z, Lavigne C, Levy E, Bachelard H, Amarouch H, Marette A, Haddad PS.

    Metabolism. 2009 Jul;58(7):909-19.PMID: 19394055 [PubMed - indexed for MEDLINE]Related articles

    20.

    Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice.

    Mercader J, Ribot J, Murano I, Feddersen S, Cinti S, Madsen L, Kristiansen K, Bonet ML, Palou A.

    Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E184-93. Epub 2009 May 5.PMID: 19417128 [PubMed - indexed for MEDLINE]Related articles

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