PubMed

Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents.

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ.

Diabetes. 2007 Aug;56(8):2085-92. Epub 2007 May 22.PMID: 17519422 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced adiposity in bitter melon (Momordica charantia)-fed rats is associated with increased lipid oxidative enzyme activities and uncoupling protein expression.

Chan LL, Chen Q, Go AG, Lam EK, Li ET.

J Nutr. 2005 Nov;135(11):2517-23.PMID: 16251604 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. Epub 2008 Dec 9.PMID: 19066218 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM.

Cell Metab. 2008 Jan;7(1):45-56.PMID: 18177724 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.PMID: 17416903 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance.

Bruce CR, Hoy AJ, Turner N, Watt MJ, Allen TL, Carpenter K, Cooney GJ, Febbraio MA, Kraegen EW.

Diabetes. 2009 Mar;58(3):550-8. Epub 2008 Dec 10.PMID: 19073774 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced capacity for fatty acid oxidation in rats with inherited susceptibility to diet-induced obesity.

Ji H, Friedman MI.

Metabolism. 2007 Aug;56(8):1124-30.PMID: 17618960 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPARgamma and key enzymes of lipid oxidation.

Samec S, Seydoux J, Russell AP, Montani JP, Dulloo AG.

Pflugers Arch. 2002 Oct;445(1):80-6. Epub 2002 Jul 17.PMID: 12397391 [PubMed - indexed for MEDLINE]Related articles

Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation.

Bezaire V, Spriet LL, Campbell S, Sabet N, Gerrits M, Bonen A, Harper ME.

FASEB J. 2005 Jun;19(8):977-9. Epub 2005 Apr 6.PMID: 15814607 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart.

Young ME, Guthrie PH, Razeghi P, Leighton B, Abbasi S, Patil S, Youker KA, Taegtmeyer H.

Diabetes. 2002 Aug;51(8):2587-95.PMID: 12145175 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.

Holloway GP, Thrush AB, Heigenhauser GJ, Tandon NN, Dyck DJ, Bonen A, Spriet LL.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1782-9. Epub 2007 Feb 20.PMID: 17311893 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha.

Cha SH, Rodgers JT, Puigserver P, Chohnan S, Lane MD.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15410-5. Epub 2006 Oct 9.PMID: 17030788 [PubMed - indexed for MEDLINE]Related articlesFree article

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites.

Lee JS, Pinnamaneni SK, Eo SJ, Cho IH, Pyo JH, Kim CK, Sinclair AJ, Febbraio MA, Watt MJ.

J Appl Physiol. 2006 May;100(5):1467-74. Epub 2005 Dec 15.PMID: 16357064 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets.

Lee YM, Choi JS, Kim MH, Jung MH, Lee YS, Song J.

Nutrition. 2006 Sep;22(9):956-64. Epub 2006 Jul 11.PMID: 16814985 [PubMed - indexed for MEDLINE]Related articles

Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia.

Smith AC, Mullen KL, Junkin KA, Nickerson J, Chabowski A, Bonen A, Dyck DJ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E172-81. Epub 2007 Mar 20.PMID: 17374701 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinoic acid treatment increases lipid oxidation capacity in skeletal muscle of mice.

Amengual J, Ribot J, Bonet ML, Palou A.

Obesity (Silver Spring). 2008 Mar;16(3):585-91. Epub 2008 Jan 17.PMID: 18239600 [PubMed - indexed for MEDLINE]Related articles

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. Epub 2008 May 16.PMID: 18487436 [PubMed - indexed for MEDLINE]Related articlesFree article

In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation.

Holloway GP, Benton CR, Mullen KL, Yoshida Y, Snook LA, Han XX, Glatz JF, Luiken JJ, Lally J, Dyck DJ, Bonen A.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E738-47. Epub 2009 Jan 13.PMID: 19141681 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction induces triglyceride accumulation in 3T3-L1 cells: role of fatty acid beta-oxidation and glucose.

Vankoningsloo S, Piens M, Lecocq C, Gilson A, De Pauw A, Renard P, Demazy C, Houbion A, Raes M, Arnould T.

J Lipid Res. 2005 Jun;46(6):1133-49. Epub 2005 Mar 1.PMID: 15741651 [PubMed - indexed for MEDLINE]Related articlesFree article

Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes.

Cabrero A, Alegret M, Sánchez RM, Adzet T, Laguna JC, Vázquez M.

Diabetes. 2001 Aug;50(8):1883-90.PMID: 11473052 [PubMed - indexed for MEDLINE]Related articlesFree article