PubMed

Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection.

Callewaert HI, Gysemans CA, Ladrière L, D'Hertog W, Hagenbrock J, Overbergh L, Eizirik DL, Mathieu C.

Diabetes. 2007 Aug;56(8):2169-73. Epub 2007 May 1.PMID: 17473223 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.

Gysemans CA, Ladrière L, Callewaert H, Rasschaert J, Flamez D, Levy DE, Matthys P, Eizirik DL, Mathieu C.

Diabetes. 2005 Aug;54(8):2396-403.PMID: 16046307 [PubMed - indexed for MEDLINE]Related articlesFree article

Combination therapy with cyclosporine and interleukin-4 or interleukin-10 prolongs survival of synergeneic pancreatic islet grafts in nonobese diabetic mice: islet graft survival does not correlate with mRNA levels of type 1 or type 2 cytokines, or transforming growth factor-beta in the islet grafts.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Rajotte RV, Power RF.

Transplantation. 1997 Dec 15;64(11):1525-31.PMID: 9415551 [PubMed - indexed for MEDLINE]Related articles

Dual role of interferon-gamma signalling pathway in sensitivity of pancreatic beta cells to immune destruction.

Gysemans CA, Pavlovic D, Bouillon R, Eizirik DL, Mathieu C.

Diabetologia. 2001 May;44(5):567-74.PMID: 11380074 [PubMed - indexed for MEDLINE]Related articles

Cytokine signalling in the beta-cell: a dual role for IFNgamma.

Gysemans C, Callewaert H, Overbergh L, Mathieu C.

Biochem Soc Trans. 2008 Jun;36(Pt 3):328-33. Review.PMID: 18481951 [PubMed - indexed for MEDLINE]Related articles

Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.

Gysemans CA, Waer M, Valckx D, Laureys JM, Mihkalsky D, Bouillon R, Mathieu C.

Diabetes. 2000 Dec;49(12):1992-7.PMID: 11117999 [PubMed - indexed for MEDLINE]Related articlesFree article

Differences in suppressor of cytokine signaling-1 (SOCS-1) expressing islet allograft destruction in normal BALB/c and spontaneously-diabetic NOD recipient mice.

Solomon M, Flodström-Tullberg M, Sarvetnick N.

Transplantation. 2005 May 15;79(9):1104-9.PMID: 15880051 [PubMed - indexed for MEDLINE]Related articles

Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice.

Smith DK, Korbutt GS, Suarez-Pinzon WL, Kao D, Rajotte RV, Elliott JF.

Transplantation. 1997 Oct 15;64(7):1040-9.PMID: 9381527 [PubMed - indexed for MEDLINE]Related articles

Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic mouse models of type 1 diabetes.

Mabley JG, Rabinovitch A, Suarez-Pinzon W, Haskó G, Pacher P, Power R, Southan G, Salzman A, Szabó C.

Mol Med. 2003 Mar-Apr;9(3-4):96-104.PMID: 12865945 [PubMed - indexed for MEDLINE]Related articlesFree article

Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice.

Kim S, Kim HS, Chung KW, Oh SH, Yun JW, Im SH, Lee MK, Kim KW, Lee MS.

Diabetes. 2007 Oct;56(10):2561-8. Epub 2007 Jul 9.PMID: 17620422 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose streptozocin-induced autoimmune diabetes in islet transplantation model.

Weide LG, Lacy PE.

Diabetes. 1991 Sep;40(9):1157-62.PMID: 1834505 [PubMed - indexed for MEDLINE]Related articles

Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection.

Guo Z, Wu T, Kirchhof N, Mital D, Williams JW, Azuma M, Sutherland DE, Hering BJ.

Transplantation. 2001 Jun 15;71(11):1656-65.PMID: 11435979 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection.

Rønn SG, Börjesson A, Bruun C, Heding PE, Frobøse H, Mandrup-Poulsen T, Karlsen AE, Rasschaert J, Sandler S, Billestrup N.

Diabetologia. 2008 Oct;51(10):1873-82. Epub 2008 Jul 22.PMID: 18648765 [PubMed - indexed for MEDLINE]Related articles

Recurrent autoimmunity accelerates destruction of minor and major histoincompatible islet grafts in nonobese diabetic (NOD) mice.

Okitsu T, Bartlett ST, Hadley GA, Drachenberg CB, Farney AC.

Am J Transplant. 2001 Jul;1(2):138-45.PMID: 12099361 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of Th1-type and Th2-type cytokine profiles in pancreatic islets of C57BL/6 and BALB/c mice by multiple low doses of streptozotocin.

Müller A, Schott-Ohly P, Dohle C, Gleichmann H.

Immunobiology. 2002 Mar;205(1):35-50.PMID: 11999343 [PubMed - indexed for MEDLINE]Related articles

In vitro xenorecognition of adult pig pancreatic islet cells by splenocytes from nonobese diabetic or non-diabetes-prone mice.

Rivereau AS, You S, Lalain S, Gouin E, Saï P.

Transplantation. 1998 Sep 15;66(5):633-8.PMID: 9753345 [PubMed - indexed for MEDLINE]Related articles

Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice. Analysis of cytokine mRNA expression in the graft.

Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF, Rajotte RV.

Transplantation. 1995 Aug 27;60(4):368-74.PMID: 7652767 [PubMed - indexed for MEDLINE]Related articles

Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice.

Zhang YC, Pileggi A, Molano RD, Wasserfall C, Campbell-Thompson M, Ricordi C, Atkinson MA, Inverardi L.

Transplantation. 2005 Aug 27;80(4):530-3.PMID: 16123729 [PubMed - indexed for MEDLINE]Related articles

Long-term islet graft survival in streptozotocin- and autoimmune-induced diabetes models by immunosuppressive and potential insulinotropic agent FTY720.

Fu F, Hu S, Deleo J, Li S, Hopf C, Hoover J, Wang S, Brinkmann V, Lake P, Shi VC.

Transplantation. 2002 May 15;73(9):1425-30.PMID: 12023620 [PubMed - indexed for MEDLINE]Related articles

Testicular Sertoli cells exert both protective and destructive effects on syngeneic islet grafts in non-obese diabetic mice.

Korbutt GS, Suarez-Pinzon WL, Power RF, Rajotte RV, Rabinovitch A.

Diabetologia. 2000 Apr;43(4):474-80.PMID: 10819241 [PubMed - indexed for MEDLINE]Related articles