PubMed

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.

Olofsson CS, Collins S, Bengtsson M, Eliasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P.

Diabetes. 2007 Jul;56(7):1888-97. Epub 2007 Apr 24.PMID: 17456851 [PubMed - indexed for MEDLINE]Related articlesFree article

Augmentation of Ca2+-stimulated insulin release by glucose and long-chain fatty acids in rat pancreatic islets: free fatty acids mimic ATP-sensitive K+ channel-independent insulinotropic action of glucose.

Komatsu M, Yajima H, Yamada S, Kaneko T, Sato Y, Yamauchi K, Hashizume K, Aizawa T.

Diabetes. 1999 Aug;48(8):1543-9.PMID: 10426371 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential mechanisms of glucose and palmitate in augmentation of insulin secretion in mouse pancreatic islets.

Thams P, Capito K.

Diabetologia. 2001 Jun;44(6):738-46.PMID: 11440367 [PubMed - indexed for MEDLINE]Related articles

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans.

Zhou YP, Grill V.

J Clin Endocrinol Metab. 1995 May;80(5):1584-90.PMID: 7745004 [PubMed - indexed for MEDLINE]Related articles

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

Collins SC, Salehi A, Eliasson L, Olofsson CS, Rorsman P.

Diabetologia. 2008 Sep;51(9):1689-93. Epub 2008 Jul 12.PMID: 18622593 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway.

Westerlund J, Ortsäter H, Palm F, Sundsten T, Bergsten P.

Eur J Endocrinol. 2001 Jun;144(6):667-75.PMID: 11375802 [PubMed - indexed for MEDLINE]Related articlesFree article

Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.

Olofsson CS, Salehi A, Holm C, Rorsman P.

J Physiol. 2004 Jun 15;557(Pt 3):935-48. Epub 2004 Apr 16.PMID: 15090611 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration.

Jacqueminet S, Briaud I, Rouault C, Reach G, Poitout V.

Metabolism. 2000 Apr;49(4):532-6.PMID: 10778881 [PubMed - indexed for MEDLINE]Related articles

Glucose triggers protein kinase A-dependent insulin secretion in mouse pancreatic islets through activation of the K+ATP channel-dependent pathway.

Thams P, Anwar MR, Capito K.

Eur J Endocrinol. 2005 Apr;152(4):671-7.PMID: 15817925 [PubMed - indexed for MEDLINE]Related articlesFree article

The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism.

Sato Y, Henquin JC.

Diabetes. 1998 Nov;47(11):1713-21.PMID: 9792540 [PubMed - indexed for MEDLINE]Related articlesFree article

ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.

Gromada J, Ma X, Høy M, Bokvist K, Salehi A, Berggren PO, Rorsman P.

Diabetes. 2004 Dec;53 Suppl 3:S181-9.PMID: 15561909 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.

Urban KA, Panten U.

Diabetologia. 2005 Dec;48(12):2563-6. Epub 2005 Nov 11.PMID: 16283243 [PubMed - indexed for MEDLINE]Related articles

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.

Diabetes. 2000 May;49(5):735-40.PMID: 10905481 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells.

Sato Y, Anello M, Henquin JC.

Endocrinology. 1999 May;140(5):2252-7.PMID: 10218978 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

Hohmeier HE, Mulder H, Chen G, Henkel-Rieger R, Prentki M, Newgard CB.

Diabetes. 2000 Mar;49(3):424-30.PMID: 10868964 [PubMed - indexed for MEDLINE]Related articlesFree article

C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition.

Buschard K, Blomqvist M, Månsson JE, Fredman P, Juhl K, Gromada J.

Diabetes. 2006 Oct;55(10):2826-34.PMID: 17003349 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content.

Anello M, Gilon P, Henquin JC.

Br J Pharmacol. 1999 Aug;127(8):1883-91.PMID: 10482920 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F.

Diabetes. 2001 Apr;50(4):803-9.PMID: 11289045 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action.

Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB.

Diabetes. 2001 Jun;50(6):1302-10.PMID: 11375330 [PubMed - indexed for MEDLINE]Related articlesFree article

Intracellular depletion of insulin: a comparative study with palmitate, oleate and elaidate in INS-1 cells.

Bollheimer LC, Kemptner DM, Kagerbauer SM, Kestler TM, Wrede CE, Buettner R.

Eur J Endocrinol. 2003 Apr;148(4):481-6.PMID: 12656670 [PubMed - indexed for MEDLINE]Related articlesFree article