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    Results: 1 to 20 of 578

    1.

    Nkx2.2 regulates beta-cell function in the mature islet.

    Doyle MJ, Sussel L.

    Diabetes. 2007 Aug;56(8):1999-2007. Epub 2007 Apr 24.PMID: 17456846 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.

    Doyle MJ, Loomis ZL, Sussel L.

    Development. 2007 Feb;134(3):515-23. Epub 2007 Jan 3.PMID: 17202186 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.

    Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV.

    Development. 2000 Jul;127(13):2883-95.PMID: 10851133 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.

    Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R.

    Mol Cell Biol. 2003 Sep;23(17):6049-62.PMID: 12917329 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.

    Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS.

    Development. 1998 Jun;125(12):2213-21.PMID: 9584121 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.

    Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R.

    Mol Cell Biol. 2006 Aug;26(15):5735-43.PMID: 16847327 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

    Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F.

    Dev Dyn. 2005 Jul;233(3):946-53.PMID: 15906379 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.

    Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M.

    Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3818-23.PMID: 11904435 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

    Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK.

    PLoS Biol. 2006 Feb;4(2):e39. Epub 2006 Jan 31.PMID: 16435884 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.

    Chao CS, Loomis ZL, Lee JE, Sussel L.

    Dev Biol. 2007 Dec 15;312(2):523-32. Epub 2007 Oct 5.PMID: 17988662 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells.

    Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, Powers AC, Gannon M.

    Diabetes. 2006 Dec;55(12):3264-70.PMID: 17130469 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas.

    Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL.

    Diabetes. 2009 Sep;58(9):2059-69. Epub 2009 Jun 5.PMID: 19502415 [PubMed - indexed for MEDLINE]Related articles

    13.

    Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

    Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.

    Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.PMID: 15194489 [PubMed - indexed for MEDLINE]Related articles

    14.

    Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

    Yamagata K, Nammo T, Moriwaki M, Ihara A, Iizuka K, Yang Q, Satoh T, Li M, Uenaka R, Okita K, Iwahashi H, Zhu Q, Cao Y, Imagawa A, Tochino Y, Hanafusa T, Miyagawa J, Matsuzawa Y.

    Diabetes. 2002 Jan;51(1):114-23.PMID: 11756330 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Distinct gene expression programs function in progenitor and mature islet cells.

    Watada H, Scheel DW, Leung J, German MS.

    J Biol Chem. 2003 May 9;278(19):17130-40. Epub 2003 Feb 25.PMID: 12604598 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

    Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

    Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.PMID: 17895289 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

    Cissell MA, Zhao L, Sussel L, Henderson E, Stein R.

    J Biol Chem. 2003 Jan 10;278(2):751-6. Epub 2002 Nov 7.PMID: 12426319 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    Neuroendocrine differentiation in the 12T-10 transgenic prostate mouse model mimics endocrine differentiation of pancreatic beta cells.

    Gupta A, Wang Y, Browne C, Kim S, Case T, Paul M, Wills ML, Matusik RJ.

    Prostate. 2008 Jan 1;68(1):50-60.PMID: 18004726 [PubMed - indexed for MEDLINE]Related articles

    19.

    Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice.

    Guo Y, Lu Y, Houle D, Robertson K, Tang Z, Kopchick JJ, Liu YL, Liu JL.

    Endocrinology. 2005 Jun;146(6):2602-9. Epub 2005 Feb 24.PMID: 15731363 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Interactions between areas I and II direct pdx-1 expression specifically to islet cell types of the mature and developing pancreas.

    Van Velkinburgh JC, Samaras SE, Gerrish K, Artner I, Stein R.

    J Biol Chem. 2005 Nov 18;280(46):38438-44. Epub 2005 Sep 7.PMID: 16147997 [PubMed - indexed for MEDLINE]Related articlesFree article

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