PubMed

LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro.

Huang TS, Myklebust LM, Kjarland E, Gjertsen BT, Pendino F, Bruserud Ø, Døskeland SO, Lillehaug JR.

Mol Cancer. 2007 Apr 23;6:31.PMID: 17451600 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.

Brown-Bryan TA, Leoh LS, Ganapathy V, Pacheco FJ, Mediavilla-Varela M, Filippova M, Linkhart TA, Gijsbers R, Debyser Z, Casiano CA.

Mol Cancer Res. 2008 Aug;6(8):1293-307.PMID: 18708362 [PubMed - indexed for MEDLINE]Related articlesFree article

t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).

Ahuja HG, Hong J, Aplan PD, Tcheurekdjian L, Forman SJ, Slovak ML.

Cancer Res. 2000 Nov 15;60(22):6227-9.PMID: 11103774 [PubMed - indexed for MEDLINE]Related articlesFree article

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.

Mediavilla-Varela M, Pacheco FJ, Almaguel F, Perez J, Sahakian E, Daniels TR, Leoh LS, Padilla A, Wall NR, Lilly MB, De Leon M, Casiano CA.

Mol Cancer. 2009 Aug 28;8:68.PMID: 19715609 [PubMed - indexed for MEDLINE]Related articlesFree article

Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing.

Singh DP, Kimura A, Chylack LT Jr, Shinohara T.

Gene. 2000 Jan 25;242(1-2):265-73.PMID: 10721720 [PubMed - indexed for MEDLINE]Related articles

Transcriptional regulation of vascular endothelial growth factor C by oxidative and thermal stress is mediated by lens epithelium-derived growth factor/p75.

Cohen B, Addadi Y, Sapoznik S, Meir G, Kalchenko V, Harmelin A, Ben-Dor S, Neeman M.

Neoplasia. 2009 Sep;11(9):921-33.PMID: 19724686 [PubMed - indexed for MEDLINE]Related articlesFree article

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y.

J Biol Chem. 2003 Aug 29;278(35):33528-39. Epub 2003 Jun 9.PMID: 12796494 [PubMed - indexed for MEDLINE]Related articlesFree article

Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain.

Chylack LT Jr, Fu L, Mancini R, Martin-Rehrmann MD, Saunders AJ, Konopka G, Tian D, Hedley-Whyte ET, Folkerth RD, Goldstein LE.

Exp Eye Res. 2004 Dec;79(6):941-8.PMID: 15642333 [PubMed - indexed for MEDLINE]Related articles

Human stem cell factor-antibody [anti-SCF] enhances chemotherapy cytotoxicity in human CD34+ resistant myeloid leukaemia cells.

Lu C, Hassan HT.

Leuk Res. 2006 Mar;30(3):296-302. Epub 2005 Aug 19.PMID: 16112192 [PubMed - indexed for MEDLINE]Related articles

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

Bartholomeeusen K, De Rijck J, Busschots K, Desender L, Gijsbers R, Emiliani S, Benarous R, Debyser Z, Christ F.

J Mol Biol. 2007 Sep 14;372(2):407-21. Epub 2007 Jul 12.PMID: 17669426 [PubMed - indexed for MEDLINE]Related articles

Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75.

Takamura Y, Fatma N, Kubo E, Singh DP.

Am J Physiol Cell Physiol. 2006 Feb;290(2):C554-66.PMID: 16403949 [PubMed - indexed for MEDLINE]Related articlesFree article

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.

Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T, Martinelli G, Conte R, Cocco L, McCubrey JA, Martelli AM.

Leukemia. 2007 Mar;21(3):427-38. Epub 2007 Jan 11.PMID: 17215852 [PubMed - indexed for MEDLINE]Related articles

Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders.

Wu X, Daniels T, Molinaro C, Lilly MB, Casiano CA.

Cell Death Differ. 2002 Sep;9(9):915-25.PMID: 12181742 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

Cherepanov P, Devroe E, Silver PA, Engelman A.

J Biol Chem. 2004 Nov 19;279(47):48883-92. Epub 2004 Sep 14.PMID: 15371438 [PubMed - indexed for MEDLINE]Related articlesFree article

Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells.

Wergeland L, Sjøholt G, Haaland I, Hovland R, Bruserud Ø, Gjertsen BT.

Mol Cancer. 2007 May 11;6:33.PMID: 17498302 [PubMed - indexed for MEDLINE]Related articlesFree article

Balance of NF-kappaB and p38 MAPK is a determinant of radiosensitivity of the AML-2 and its doxorubicin-resistant cell lines.

Choi CH, Xu H, Bark H, Lee TB, Yun J, Kang SI, Oh YK.

Leuk Res. 2007 Sep;31(9):1267-76. Epub 2007 Jan 10.PMID: 17218010 [PubMed - indexed for MEDLINE]Related articles

Acute myeloid leukemia cells are protected from spontaneous and drug-induced apoptosis by direct contact with a human bone marrow stromal cell line (HS-5).

Garrido SM, Appelbaum FR, Willman CL, Banker DE.

Exp Hematol. 2001 Apr;29(4):448-57.PMID: 11301185 [PubMed - indexed for MEDLINE]Related articles

Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.

Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A.

J Biol Chem. 2004 Aug 6;279(32):33421-9. Epub 2004 May 25.PMID: 15163664 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C.

Keith FJ, Bradbury DA, Zhu YM, Russell NH.

Leukemia. 1995 Jan;9(1):131-8.PMID: 7845007 [PubMed - indexed for MEDLINE]Related articles

Blasts from elderly acute myeloid leukemia patients are characterized by low levels of culture- and drug-induced apoptosis.

Garrido SM, Cooper JJ, Appelbaum FR, Willman CL, Kopecky K, Banker DE.

Leuk Res. 2001 Jan;25(1):23-32.PMID: 11137557 [PubMed - indexed for MEDLINE]Related articles