PubMed

Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms.

Wahrle SE, Shah AR, Fagan AM, Smemo S, Kauwe JS, Grupe A, Hinrichs A, Mayo K, Jiang H, Thal LJ, Goate AM, Holtzman DM.

Mol Neurodegener. 2007 Apr 12;2:7.PMID: 17430597 [PubMed]Related articlesFree article

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.

Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM.

J Biol Chem. 2005 Dec 30;280(52):43236-42. Epub 2005 Oct 5.PMID: 16207708 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels.

Bekris LM, Millard SP, Galloway NM, Vuletic S, Albers JJ, Li G, Galasko DR, DeCarli C, Farlow MR, Clark CM, Quinn JF, Kaye JA, Schellenberg GD, Tsuang D, Peskind ER, Yu CE.

J Alzheimers Dis. 2008 Apr;13(3):255-66.PMID: 18430993 [PubMed - indexed for MEDLINE]Related articles

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.

Koldamova R, Staufenbiel M, Lefterov I.

J Biol Chem. 2005 Dec 30;280(52):43224-35. Epub 2005 Oct 5.PMID: 16207713 [PubMed - indexed for MEDLINE]Related articlesFree article

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, Holtzman DM.

J Biol Chem. 2004 Sep 24;279(39):40987-93. Epub 2004 Jul 21.PMID: 15269217 [PubMed - indexed for MEDLINE]Related articlesFree article

TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.

Laws SM, Perneczky R, Wagenpfeil S, Müller U, Förstl H, Martins RN, Kurz A, Riemenschneider M.

Hum Mutat. 2005 Jul;26(1):29-35.PMID: 15895461 [PubMed - indexed for MEDLINE]Related articles

Why lipids are important for Alzheimer disease?

Hirsch-Reinshagen V, Burgess BL, Wellington CL.

Mol Cell Biochem. 2009 Jun;326(1-2):121-9. Epub 2008 Dec 31.PMID: 19116777 [PubMed - indexed for MEDLINE]Related articles

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM.

J Clin Invest. 2008 Feb;118(2):671-82.PMID: 18202749 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism.

Katzov H, Chalmers K, Palmgren J, Andreasen N, Johansson B, Cairns NJ, Gatz M, Wilcock GK, Love S, Pedersen NL, Brookes AJ, Blennow K, Kehoe PG, Prince JA.

Hum Mutat. 2004 Apr;23(4):358-67.PMID: 15024730 [PubMed - indexed for MEDLINE]Related articles

Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk.

Rodríguez-Rodríguez E, Mateo I, Infante J, Llorca J, García-Gorostiaga I, Vázquez-Higuera JL, Sánchez-Juan P, Berciano J, Combarros O.

Brain Res. 2009 Jul 14;1280:166-71. Epub 2009 May 14.PMID: 19446537 [PubMed - indexed for MEDLINE]Related articles

Gender-specific association of ATP-binding cassette transporter 1 (ABCA1) polymorphisms with the risk of late-onset Alzheimer's disease.

Sundar PD, Feingold E, Minster RL, DeKosky ST, Kamboh MI.

Neurobiol Aging. 2007 Jun;28(6):856-62. Epub 2006 May 24.PMID: 16725228 [PubMed - indexed for MEDLINE]Related articles

[Correlation of cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 polymorphisms with Alzheimer's disease]

Wang F, Jia JP.

Zhonghua Yi Xue Za Zhi. 2007 Mar 6;87(9):614-8. Chinese. PMID: 17550732 [PubMed - indexed for MEDLINE]Related articles

Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition.

Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM, Holtzman DM, Goate AM.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8050-4. Epub 2008 Jun 9.PMID: 18541914 [PubMed - indexed for MEDLINE]Related articlesFree article

APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.

Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA.

Ann Neurol. 2010 Jan;67(1):122-31.PMID: 20186853 [PubMed - in process]Related articles

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.

Blom ES, Giedraitis V, Zetterberg H, Fukumoto H, Blennow K, Hyman BT, Irizarry MC, Wahlund LO, Lannfelt L, Ingelsson M.

Dement Geriatr Cogn Disord. 2009;27(5):458-64. Epub 2009 May 7.PMID: 19420940 [PubMed - indexed for MEDLINE]Related articles

ABCA1 modulates CSF cholesterol levels and influences the age at onset of Alzheimer's disease.

Wollmer MA, Streffer JR, Lütjohann D, Tsolaki M, Iakovidou V, Hegi T, Pasch T, Jung HH, Bergmann K, Nitsch RM, Hock C, Papassotiropoulos A.

Neurobiol Aging. 2003 May-Jun;24(3):421-6.PMID: 12600718 [PubMed - indexed for MEDLINE]Related articles

Association of genetic variants of ABCA1 with Alzheimer's disease risk.

Rodríguez-Rodríguez E, Mateo I, Llorca J, Sánchez-Quintana C, Infante J, García-Gorostiaga I, Sánchez-Juan P, Berciano J, Combarros O.

Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):964-8.PMID: 17510946 [PubMed - indexed for MEDLINE]Related articles

Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.

Ewers M, Zhong Z, Bürger K, Wallin A, Blennow K, Teipel SJ, Shen Y, Hampel H.

Brain. 2008 May;131(Pt 5):1252-8. Epub 2008 Mar 11.PMID: 18334538 [PubMed - indexed for MEDLINE]Related articlesFree article

Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E.

Fan J, Donkin J, Wellington C.

Biofactors. 2009 May-Jun;35(3):239-48. Review.PMID: 19472365 [PubMed - indexed for MEDLINE]Related articles

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL.

J Biol Chem. 2005 Dec 30;280(52):43243-56. Epub 2005 Oct 5.PMID: 16207707 [PubMed - indexed for MEDLINE]Related articlesFree article