PubMed

Glucose infusion in mice: a new model to induce beta-cell replication.

Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A.

Diabetes. 2007 Jul;56(7):1792-801. Epub 2007 Mar 30.PMID: 17400928 [PubMed - indexed for MEDLINE]Related articlesFree article

Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice.

Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP.

J Physiol. 2008 Feb 1;586(3):899-911. Epub 2007 Nov 22.PMID: 18033815 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB.

Mol Cell Biol. 2008 May;28(10):3465-76. Epub 2008 Mar 17.PMID: 18347054 [PubMed - indexed for MEDLINE]Related articlesFree article

High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets.

Rafacho A, Cestari TM, Taboga SR, Boschero AC, Bosqueiro JR.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E681-9. Epub 2009 Jan 21.PMID: 19158320 [PubMed - indexed for MEDLINE]Related articles

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

Georgia S, Bhushan A.

J Clin Invest. 2004 Oct;114(7):963-8.PMID: 15467835 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8977-82. Epub 2007 Apr 6.PMID: 17416680 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

Brun T, He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR.

Hum Mol Genet. 2008 Feb 15;17(4):478-89. Epub 2007 Nov 7.PMID: 17989064 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.

Morioka T, Asilmaz E, Hu J, Dishinger JF, Kurpad AJ, Elias CF, Li H, Elmquist JK, Kennedy RT, Kulkarni RN.

J Clin Invest. 2007 Oct;117(10):2860-8.PMID: 17909627 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo.

Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A.

Diabetes. 2007 Nov;56(11):2722-31. Epub 2007 Aug 6.PMID: 17682092 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent.

Kushner JA.

Cell Cycle. 2006 Feb;5(3):234-7. Epub 2006 Feb 9.PMID: 16410729 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid.

Gustavsson N, Larsson-Nyrén G, Lindström P.

Pancreas. 2005 Oct;31(3):242-50.PMID: 16163056 [PubMed - indexed for MEDLINE]Related articles

Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.

Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S.

Gastroenterology. 2008 Mar;134(3):727-37. Epub 2008 Feb 1.PMID: 18241861 [PubMed - indexed for MEDLINE]Related articles

Exendin-4 treatment expands graft beta-cell mass in diabetic mice transplanted with a marginal number of fresh islets.

Juang JH, Kuo CH, Wu CH, Juang C.

Cell Transplant. 2008;17(6):641-7.PMID: 18819252 [PubMed - indexed for MEDLINE]Related articles

Metabolic adaptations to chronic glucose infusion in rats.

Topp BG, McArthur MD, Finegood DT.

Diabetologia. 2004 Sep;47(9):1602-10. Epub 2004 Sep 2.PMID: 15349726 [PubMed - indexed for MEDLINE]Related articles

Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion.

Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L.

Mol Cell Biol. 2007 Sep;27(17):6026-37. Epub 2007 Jun 18. Erratum in: Mol Cell Biol. 2007 Oct;27(20):7354. PMID: 17576812 [PubMed - indexed for MEDLINE]Related articlesFree article

ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.

Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M.

Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):674-9. Epub 2008 Jan 4.PMID: 18178618 [PubMed - indexed for MEDLINE]Related articlesFree article

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Keller MP, Choi Y, Wang P, Davis DB, Rabaglia ME, Oler AT, Stapleton DS, Argmann C, Schueler KL, Edwards S, Steinberg HA, Chaibub Neto E, Kleinhanz R, Turner S, Hellerstein MK, Schadt EE, Yandell BS, Kendziorski C, Attie AD.

Genome Res. 2008 May;18(5):706-16. Epub 2008 Mar 17.PMID: 18347327 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchangeR NHE1.

Stiernet P, Nenquin M, Moulin P, Jonas JC, Henquin JC.

J Biol Chem. 2007 Aug 24;282(34):24538-46. Epub 2007 Jun 28.PMID: 17599909 [PubMed - indexed for MEDLINE]Related articlesFree article

Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.

Klinger S, Poussin C, Debril MB, Dolci W, Halban PA, Thorens B.

Diabetes. 2008 Mar;57(3):584-93. Epub 2007 Nov 19.PMID: 18025410 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets.

Pascal SM, Guiot Y, Pelengaris S, Khan M, Jonas JC.

Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E92-102. Epub 2008 Apr 15.PMID: 18413670 [PubMed - indexed for MEDLINE]Related articlesFree article