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    Results: 1 to 20 of 241

    1.

    Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy.

    Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH.

    Diabetes. 2007 Apr;56(4):930-9.PMID: 17395740 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy.

    Szeto J, Kaniuk NA, Canadien V, Nisman R, Mizushima N, Yoshimori T, Bazett-Jones DP, Brumell JH.

    Autophagy. 2006 Jul-Sep;2(3):189-99. Epub 2006 Jul 22.PMID: 16874109 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic beta-cells.

    Hartley T, Brumell J, Volchuk A.

    Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E1-10. Epub 2008 Sep 23. Review.PMID: 18812463 [PubMed - indexed for MEDLINE]Related articles

    4.

    IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.

    Potashnik R, Bloch-Damti A, Bashan N, Rudich A.

    Diabetologia. 2003 May;46(5):639-48. Epub 2003 May 15.PMID: 12750770 [PubMed - indexed for MEDLINE]Related articles

    5.

    Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.

    Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS.

    Cell Metab. 2008 Oct;8(4):318-24.PMID: 18840362 [PubMed - indexed for MEDLINE]Related articles

    6.

    Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.

    Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP.

    Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10857-62.PMID: 10485916 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Oxidative stress and pancreatic beta-cell dysfunction.

    Kaneto H, Kawamori D, Matsuoka TA, Kajimoto Y, Yamasaki Y.

    Am J Ther. 2005 Nov-Dec;12(6):529-33. Review.PMID: 16280646 [PubMed - indexed for MEDLINE]Related articles

    8.

    A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

    Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T.

    Mol Cell. 2009 Feb 27;33(4):505-16.PMID: 19250911 [PubMed - indexed for MEDLINE]Related articles

    9.

    Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

    Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

    Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).

    Fujita E, Kouroku Y, Isoai A, Kumagai H, Misutani A, Matsuda C, Hayashi YK, Momoi T.

    Hum Mol Genet. 2007 Mar 15;16(6):618-29. Epub 2007 Mar 1.PMID: 17331981 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery.

    Bjørkøy G, Lamark T, Johansen T.

    Autophagy. 2006 Apr-Jun;2(2):138-9. Epub 2006 Apr 14.PMID: 16874037 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells.

    Li Z, Arnaud L, Rockwell P, Figueiredo-Pereira ME.

    J Neurochem. 2004 Jul;90(1):19-28.PMID: 15198663 [PubMed - indexed for MEDLINE]Related articles

    13.

    Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy.

    Tannous P, Zhu H, Nemchenko A, Berry JM, Johnstone JL, Shelton JM, Miller FJ Jr, Rothermel BA, Hill JA.

    Circulation. 2008 Jun 17;117(24):3070-8. Epub 2008 Jun 9.PMID: 18541737 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.

    Casas S, Gomis R, Gribble FM, Altirriba J, Knuutila S, Novials A.

    Diabetes. 2007 Sep;56(9):2284-94. Epub 2007 Jun 11.PMID: 17563070 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.

    Tank EM, True HL.

    PLoS Genet. 2009 Feb;5(2):e1000382. Epub 2009 Feb 13.PMID: 19214209 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Removal of oxidatively damaged proteins from lens cells by the ubiquitin-proteasome pathway.

    Shang F, Nowell TR Jr, Taylor A.

    Exp Eye Res. 2001 Aug;73(2):229-38.PMID: 11446773 [PubMed - indexed for MEDLINE]Related articles

    17.

    Proteasomal defense of oxidative protein modifications.

    Poppek D, Grune T.

    Antioxid Redox Signal. 2006 Jan-Feb;8(1-2):173-84. Review.PMID: 16487051 [PubMed - indexed for MEDLINE]Related articles

    18.

    Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells.

    Figueiredo-Pereira ME, Yakushin S, Cohen G.

    J Biol Chem. 1998 May 22;273(21):12703-9.PMID: 9582293 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Emerging role for autophagy in the removal of aggresomes in Schwann cells.

    Fortun J, Dunn WA Jr, Joy S, Li J, Notterpek L.

    J Neurosci. 2003 Nov 19;23(33):10672-80.PMID: 14627652 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.

    Komatsu M, Ueno T, Waguri S, Uchiyama Y, Kominami E, Tanaka K.

    Cell Death Differ. 2007 May;14(5):887-94. Epub 2007 Mar 2. Review.PMID: 17332773 [PubMed - indexed for MEDLINE]Related articlesFree article

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