PubMed

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L.

Diabetes. 2007 Jul;56(7):1773-82. Epub 2007 Mar 27.PMID: 17389332 [PubMed - indexed for MEDLINE]Related articlesFree article

Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.

Farrelly D, Brown KS, Tieman A, Ren J, Lira SA, Hagan D, Gregg R, Mookhtiar KA, Hariharan N.

Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14511-6.PMID: 10588736 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI).

Burke CV, Buettger CW, Davis EA, McClane SJ, Matschinsky FM, Raper SE.

Biochem J. 1999 Sep 1;342 ( Pt 2):345-52.PMID: 10455021 [PubMed - indexed for MEDLINE]Related articlesFree article

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemical Characterization of MODY2 Glucokinase Variants V62M and G72R Reveals Reduced Enzymatic Activities Relative to Wild-type.

Sun S.

Biochemistry. 2009 Feb 2. [Epub ahead of print]PMID: 19187021 [PubMed - as supplied by publisher]Related articles

From clinicogenetic studies of maturity-onset diabetes of the young to unraveling complex mechanisms of glucokinase regulation.

Sagen JV, Odili S, Bjørkhaug L, Zelent D, Buettger C, Kwagh J, Stanley C, Dahl-Jørgensen K, de Beaufort C, Bell GI, Han Y, Grimsby J, Taub R, Molven A, Søvik O, Njølstad PR, Matschinsky FM.

Diabetes. 2006 Jun;55(6):1713-22.PMID: 16731834 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA.

J Biol Chem. 2007 May 4;282(18):13906-16. Epub 2007 Mar 12.PMID: 17353190 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.

de la Iglesia N, Veiga-da-Cunha M, Van Schaftingen E, Guinovart JJ, Ferrer JC.

FEBS Lett. 1999 Aug 6;456(2):332-8.PMID: 10456334 [PubMed - indexed for MEDLINE]Related articles

Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.

Heredia VV, Carlson TJ, Garcia E, Sun S.

J Biol Chem. 2006 Dec 29;281(52):40201-7. Epub 2006 Nov 2.PMID: 17082186 [PubMed - indexed for MEDLINE]Related articlesFree article

Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.

Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S.

Am J Physiol. 1997 Oct;273(4 Pt 1):E743-50.PMID: 9357804 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.

Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA.

J Biol Chem. 1999 Jan 1;274(1):305-15.PMID: 9867845 [PubMed - indexed for MEDLINE]Related articlesFree article

A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.

Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ.

Endocrinology. 2004 Feb;145(2):650-8. Epub 2003 Nov 14.PMID: 14617577 [PubMed - indexed for MEDLINE]Related articlesFree article

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L.

Biochem J. 2008 Apr 1;411(1):41-51.PMID: 18039179 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell-specific roles of glucokinase in glucose homeostasis.

Postic C, Shiota M, Magnuson MA.

Recent Prog Horm Res. 2001;56:195-217. Review.PMID: 11237213 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells.

Massa L, Baltrusch S, Okar DA, Lange AJ, Lenzen S, Tiedge M.

Diabetes. 2004 Apr;53(4):1020-9.PMID: 15047617 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase:glucokinase complex.

Smith WE, Langer S, Wu C, Baltrusch S, Okar DA.

Mol Endocrinol. 2007 Jun;21(6):1478-87. Epub 2007 Mar 20.PMID: 17374851 [PubMed - indexed for MEDLINE]Related articlesFree article

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.

Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y.

J Biol Chem. 2006 Dec 8;281(49):37668-74. Epub 2006 Oct 6.PMID: 17028192 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype.

Miller SP, Anand GR, Karschnia EJ, Bell GI, LaPorte DC, Lange AJ.

Diabetes. 1999 Aug;48(8):1645-51.PMID: 10426385 [PubMed - indexed for MEDLINE]Related articlesFree article

Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme.

Liang Y, Kesavan P, Wang LQ, Niswender K, Tanizawa Y, Permutt MA, Magnuson MA, Matschinsky FM.

Biochem J. 1995 Jul 1;309 ( Pt 1):167-73.PMID: 7619052 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.

Baltrusch S, Langer S, Massa L, Tiedge M, Lenzen S.

Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.PMID: 16980436 [PubMed - indexed for MEDLINE]Related articlesFree article