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The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases.

Omoigui S.

Immun Ageing. 2007 Mar 20;4:1.PMID: 17374166 [PubMed]Free PMC ArticleFree textRelated citations

Cholesterol synthesis is the trigger and isoprenoid dependent interleukin-6 mediated inflammation is the common causative factor and therapeutic target for atherosclerotic vascular disease and age-related disorders including osteoporosis and type 2 diabetes.

Omoigui S.

Med Hypotheses. 2005;65(3):559-69.PMID: 15935563 [PubMed - indexed for MEDLINE]Related citations

Dietary approaches that delay age-related diseases.

Everitt AV, Hilmer SN, Brand-Miller JC, Jamieson HA, Truswell AS, Sharma AP, Mason RS, Morris BJ, Le Couteur DG.

Clin Interv Aging. 2006;1(1):11-31. Review.PMID: 18047254 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

[Coronary heart disease and osteoporosis: factors related to development of both diseases]

Nowicka G, Panczenko-Kresowska B.

Przegl Lek. 2007;64(3):153-8. Review. Polish. PMID: 17941467 [PubMed - indexed for MEDLINE]Related citations

Pleiotropic effects of statins and related pharmacological experimental approaches.

Alegret M, Silvestre JS.

Timely Top Med Cardiovasc Dis. 2007 Apr 18;11:E10.PMID: 17473899 [PubMed]Free ArticleRelated citations

Fruit polyphenols and their effects on neuronal signaling and behavior in senescence.

Joseph JA, Shukitt-Hale B, Lau FC.

Ann N Y Acad Sci. 2007 Apr;1100:470-85. Review.PMID: 17460212 [PubMed - indexed for MEDLINE]Related citations

Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress.

Lau FC, Shukitt-Hale B, Joseph JA.

Subcell Biochem. 2007;42:299-318. Review.PMID: 17612057 [PubMed - indexed for MEDLINE]Related citations

Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.

Rodríguez-Vita J, Sánchez-Galán E, Santamaría B, Sánchez-López E, Rodrigues-Díez R, Blanco-Colio LM, Egido J, Ortiz A, Ruiz-Ortega M.

PLoS One. 2008;3(12):e3959. Epub 2008 Dec 17.PMID: 19088845 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Therapeutic potential of statins in Alzheimer's disease.

Kandiah N, Feldman HH.

J Neurol Sci. 2009 Aug 15;283(1-2):230-4. Epub 2009 Mar 24. Review.PMID: 19321181 [PubMed - indexed for MEDLINE]Related citations

Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.

Gan L.

Drug News Perspect. 2007 May;20(4):233-9. Review.PMID: 17637936 [PubMed - indexed for MEDLINE]Related citations

Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry.

Sottero B, Gamba P, Gargiulo S, Leonarduzzi G, Poli G.

Curr Med Chem. 2009;16(6):685-705. Review.PMID: 19199932 [PubMed - indexed for MEDLINE]Related citations

Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency.

Yu B, Becnel J, Zerfaoui M, Rohatgi R, Boulares AH, Nichols CD.

J Pharmacol Exp Ther. 2008 Nov;327(2):316-23. Epub 2008 Aug 15.PMID: 18708586 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Statins inhibit Rho kinase activity in patients with atherosclerosis.

Nohria A, Prsic A, Liu PY, Okamoto R, Creager MA, Selwyn A, Liao JK, Ganz P.

Atherosclerosis. 2009 Aug;205(2):517-21. Epub 2008 Dec 24.PMID: 19167712 [PubMed - indexed for MEDLINE]Related citations

Molecular mechanism of PPAR in the regulation of age-related inflammation.

Chung JH, Seo AY, Chung SW, Kim MK, Leeuwenburgh C, Yu BP, Chung HY.

Ageing Res Rev. 2008 Apr;7(2):126-36. Epub 2008 Jan 19. Review.PMID: 18313368 [PubMed - indexed for MEDLINE]Related citations

Immunomodulation by statins: inhibition of cholesterol vs. isoprenoid biosynthesis.

Kuipers HF, van den Elsen PJ.

Biomed Pharmacother. 2007 Aug;61(7):400-7. Epub 2007 Jul 5. Review.PMID: 17643927 [PubMed - indexed for MEDLINE]Related citations

RAGE signaling in inflammation and arterial aging.

Lin L, Park S, Lakatta EG.

Front Biosci. 2009 Jan 1;14:1403-13. Review.PMID: 19273137 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins.

Reid PC, Urano Y, Kodama T, Hamakubo T.

J Cell Mol Med. 2007 May-Jun;11(3):383-92. Review.PMID: 17635634 [PubMed - indexed for MEDLINE]Related citations

Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons.

Bucelli RC, Gonsiorek EA, Kim WY, Bruun D, Rabin RA, Higgins D, Lein PJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):1172-80. Epub 2007 Dec 13.PMID: 18079356 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Exercise, vascular wall and cardiovascular diseases: an update (Part 1).

Leung FP, Yung LM, Laher I, Yao X, Chen ZY, Huang Y.

Sports Med. 2008;38(12):1009-24. doi: 10.2165/00007256-200838120-00005. Review.PMID: 19026018 [PubMed - indexed for MEDLINE]Related citations

Molecular inflammation: underpinnings of aging and age-related diseases.

Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C.

Ageing Res Rev. 2009 Jan;8(1):18-30. Epub 2008 Jul 18. Review.PMID: 18692159 [PubMed - indexed for MEDLINE]Related citations