PubMed

Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.

Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, Lee KM, Park KG, Lee IK, Kim JB.

Diabetes. 2007 Jun;56(6):1534-43. Epub 2007 Mar 16.PMID: 17369526 [PubMed - indexed for MEDLINE]Related articlesFree article

Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.

Green CD, Jump DB, Olson LK.

Endocrinology. 2009 Jun;150(6):2637-45. Epub 2009 Feb 19.PMID: 19228891 [PubMed - indexed for MEDLINE]Related articles

Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest.

Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X.

Diabetologia. 2009 Jan;52(1):125-35. Epub 2008 Oct 24.PMID: 18949453 [PubMed - indexed for MEDLINE]Related articles

Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

Lund EG, Peterson LB, Adams AD, Lam MH, Burton CA, Chin J, Guo Q, Huang S, Latham M, Lopez JC, Menke JG, Milot DP, Mitnaul LJ, Rex-Rabe SE, Rosa RL, Tian JY, Wright SD, Sparrow CP.

Biochem Pharmacol. 2006 Feb 14;71(4):453-63. Epub 2005 Dec 2.PMID: 16325781 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9. Epub 2006 Jul 6.PMID: 16825483 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

Wente W, Brenner MB, Zitzer H, Gromada J, Efanov AM.

Endocrinology. 2007 Apr;148(4):1843-9. Epub 2006 Dec 28.PMID: 17194744 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression.

Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MG, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, Kim JB.

Mol Cell Biol. 2004 Apr;24(8):3430-44.PMID: 15060163 [PubMed - indexed for MEDLINE]Related articlesFree article

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse.

Chisholm JW, Hong J, Mills SA, Lawn RM.

J Lipid Res. 2003 Nov;44(11):2039-48. Epub 2003 Aug 16.PMID: 12923232 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC.

Endocrinology. 2006 Nov;147(11):5061-8. Epub 2006 Jul 27.PMID: 16873540 [PubMed - indexed for MEDLINE]Related articlesFree article

Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

Zitzer H, Wente W, Brenner MB, Sewing S, Buschard K, Gromada J, Efanov AM.

Endocrinology. 2006 Aug;147(8):3898-905. Epub 2006 Apr 27.PMID: 16644917 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha.

Kim K, Kim KH, Kim HH, Cheong J.

Biochem J. 2008 Dec 1;416(2):219-30.PMID: 18782084 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.

Cozzone D, Debard C, Dif N, Ricard N, Disse E, Vouillarmet J, Rabasa-Lhoret R, Laville M, Pruneau D, Rieusset J, Lefai E, Vidal H.

Diabetologia. 2006 May;49(5):990-9. Epub 2006 Feb 16.PMID: 16482468 [PubMed - indexed for MEDLINE]Related articles

Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes.

Madsen L, Petersen RK, Steffensen KR, Pedersen LM, Hallenborg P, Ma T, Frøyland L, Døskeland SO, Gustafsson JA, Kristiansen K.

J Biol Chem. 2008 Aug 15;283(33):22723-36. Epub 2008 May 16.PMID: 18487205 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility.

Volle DH, Mouzat K, Duggavathi R, Siddeek B, Déchelotte P, Sion B, Veyssière G, Benahmed M, Lobaccaro JM.

Mol Endocrinol. 2007 May;21(5):1014-27. Epub 2007 Mar 6.PMID: 17341595 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.

Efanov AM, Sewing S, Bokvist K, Gromada J.

Diabetes. 2004 Dec;53 Suppl 3:S75-8.PMID: 15561926 [PubMed - indexed for MEDLINE]Related articlesFree article

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.

Cha JY, Repa JJ.

J Biol Chem. 2007 Jan 5;282(1):743-51. Epub 2006 Nov 14.PMID: 17107947 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissection of the insulin-sensitizing effect of liver X receptor ligands.

Commerford SR, Vargas L, Dorfman SE, Mitro N, Rocheford EC, Mak PA, Li X, Kennedy P, Mullarkey TL, Saez E.

Mol Endocrinol. 2007 Dec;21(12):3002-12. Epub 2007 Aug 23.PMID: 17717069 [PubMed - indexed for MEDLINE]Related articlesFree article

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.

Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA.

J Biol Chem. 2005 Jun 17;280(24):23024-31. Epub 2005 Apr 13.PMID: 15831500 [PubMed - indexed for MEDLINE]Related articlesFree article

The nuclear receptor LXR is a glucose sensor.

Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E.

Nature. 2007 Jan 11;445(7124):219-23. Epub 2006 Dec 24.PMID: 17187055 [PubMed - indexed for MEDLINE]Related articles