PubMed

Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish.

Fu M, Sabra MM, Damcott C, Pollin TI, Ma L, Ott S, Shelton JC, Shi X, Reinhart L, O'Connell J, Mitchell BD, Baier LJ, Shuldiner AR.

Diabetes. 2007 May;56(5):1363-8. Epub 2007 Mar 16.PMID: 17369523 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.

Ma L, Hanson RL, Que LN, Cali AM, Fu M, Mack JL, Infante AM, Kobes S; International Type 2 Diabetes 1q Consortium, Bogardus C, Shuldiner AR, Baier LJ.

Diabetes. 2007 May;56(5):1454-9. Epub 2007 Feb 7.PMID: 17287471 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

Damcott CM, Pollin TI, Reinhart LJ, Ott SH, Shen H, Silver KD, Mitchell BD, Shuldiner AR.

Diabetes. 2006 Sep;55(9):2654-9.PMID: 16936218 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphism in the calsequestrin 1 (CASQ1) gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish.

Fu M, Damcott CM, Sabra M, Pollin TI, Ott SH, Wang J, Garant MJ, O'Connell JR, Mitchell BD, Shuldiner AR.

Diabetes. 2004 Dec;53(12):3292-9.PMID: 15561962 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish.

Damcott CM, Hoppman N, Ott SH, Reinhart LJ, Wang J, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR.

Diabetes. 2004 Dec;53(12):3337-41.PMID: 15561969 [PubMed - indexed for MEDLINE]Related articlesFree article

R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians.

Böttcher Y, Schleinitz D, Tönjes A, Blüher M, Stumvoll M, Kovacs P.

J Hum Genet. 2008;53(4):365-7. Epub 2008 Jan 31.PMID: 18231709 [PubMed - indexed for MEDLINE]Related articles

Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians.

Muller YL, Hanson RL, Zimmerman C, Harper I, Sutherland J, Kobes S; International Type 2 Diabetes 1q Consortium, Knowler WC, Bogardus C, Baier LJ.

Diabetes. 2007 Dec;56(12):3089-94. Epub 2007 Aug 24.PMID: 17720895 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.

Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR.

Diabetes. 2007 Dec;56(12):3053-62. Epub 2007 Sep 10.PMID: 17846126 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.

Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'connell JR, Mitchell BD, Shuldiner AR.

Diabetes. 2005 Jul;54(7):2245-50.PMID: 15983228 [PubMed - indexed for MEDLINE]Related articlesFree article

Betacellulin variants and type 2 diabetes in the Old Order Amish.

Silver KD, Shi X, Mitchell BD.

Exp Clin Endocrinol Diabetes. 2007 Apr;115(4):229-31.PMID: 17479438 [PubMed - indexed for MEDLINE]Related articles

Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians.

Das SK, Chu W, Zhang Z, Hasstedt SJ, Elbein SC.

Diabetes. 2004 Dec;53(12):3300-6.PMID: 15561963 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation in the lamin A/C gene: associations with metabolic syndrome.

Steinle NI, Kazlauskaite R, Imumorin IG, Hsueh WC, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR.

Arterioscler Thromb Vasc Biol. 2004 Sep;24(9):1708-13. Epub 2004 Jun 17.PMID: 15205219 [PubMed - indexed for MEDLINE]Related articlesFree article

Vesicle-associated membrane protein 4, a positional candidate gene on 1q24-q25, is not associated with type 2 diabetes in the Old Order Amish.

Sabra MM, Damcott C, Fu M, Ott S, O'Connell JR, Mitchell BD, Shuldiner AR.

Mol Genet Metab. 2005 Jun;85(2):133-9.PMID: 15896658 [PubMed - indexed for MEDLINE]Related articles

Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study).

Holzapfel C, Klopp N, Grallert H, Huth C, Gieger C, Meisinger C, Strassburger K, Giani G, Wichmann HE, Laumen H, Hauner H, Herder C, Rathmann W, Illig T.

Eur J Endocrinol. 2007 Sep;157(3):R1-5.PMID: 17766704 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians.

Långberg EC, Gu HF, Nordman S, Efendic S, Ostenson CG.

Eur J Endocrinol. 2007 Oct;157(4):459-64.PMID: 17893260 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression.

Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, Stumvoll M.

Diabetes. 2007 Dec;56(12):3095-100. Epub 2007 Aug 29.PMID: 17728376 [PubMed - indexed for MEDLINE]Related articlesFree article

Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.

Wang L, Hauser ER, Shah SH, Pericak-Vance MA, Haynes C, Crosslin D, Harris M, Nelson S, Hale AB, Granger CB, Haines JL, Jones CJ, Crossman D, Seo D, Gregory SG, Kraus WE, Goldschmidt-Clermont PJ, Vance JM.

Am J Hum Genet. 2007 Apr;80(4):650-63. Epub 2007 Feb 8.PMID: 17357071 [PubMed - indexed for MEDLINE]Related articlesFree article

Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians.

Gu HF, Abulaiti A, Ostenson CG, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S.

Diabetes. 2004 Feb;53 Suppl 1:S31-5.PMID: 14749263 [PubMed - indexed for MEDLINE]Related articlesFree article

A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.

Horikoshi M, Hara K, Ohashi J, Miyake K, Tokunaga K, Ito C, Kasuga M, Nagai R, Kadowaki T.

Diabetes. 2006 Apr;55(4):919-23.PMID: 16567511 [PubMed - indexed for MEDLINE]Related articlesFree article

Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.

Muller YL, Infante AM, Hanson RL, Love-Gregory L, Knowler W, Bogardus C, Baier LJ.

Diabetes. 2005 Oct;54(10):3035-9.PMID: 16186411 [PubMed - indexed for MEDLINE]Related articlesFree article