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    Results: 1 to 20 of 399

    1.

    Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice.

    Flowers JB, Rabaglia ME, Schueler KL, Flowers MT, Lan H, Keller MP, Ntambi JM, Attie AD.

    Diabetes. 2007 May;56(5):1228-39. Epub 2007 Mar 16.PMID: 17369521 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice.

    Miyazaki M, Sampath H, Liu X, Flowers MT, Chu K, Dobrzyn A, Ntambi JM.

    Biochem Biophys Res Commun. 2009 Mar 20;380(4):818-22. Epub 2009 Feb 5.PMID: 19338759 [PubMed - indexed for MEDLINE]Related articles

    3.

    Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.

    Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR.

    Diabetes. 2006 Jul;55(7):2032-41.PMID: 16804073 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation.

    Dobrzyń A, Dobrzyń P.

    J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. Review.PMID: 17242489 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes.

    Attie AD, Flowers MT, Flowers JB, Groen AK, Kuipers F, Ntambi JM.

    Novartis Found Symp. 2007;286:47-53; discussion 54-7, 162-3, 196-203.PMID: 18269173 [PubMed - indexed for MEDLINE]Related articles

    6.

    Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity.

    Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD.

    Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11482-6. Epub 2002 Aug 12.PMID: 12177411 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.

    Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

    Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E599-607. Epub 2004 Nov 23.PMID: 15562249 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Stearoyl-CoA desaturase as a new drug target for obesity treatment.

    Dobrzyn A, Ntambi JM.

    Obes Rev. 2005 May;6(2):169-74. Review.PMID: 15836467 [PubMed - indexed for MEDLINE]Related articles

    9.

    Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.

    Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi JM.

    Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E357-64. Epub 2007 Nov 27.PMID: 18042664 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    The role of stearoyl-CoA desaturase in body weight regulation.

    Dobrzyn A, Ntambi JM.

    Trends Cardiovasc Med. 2004 Feb;14(2):77-81. Review.PMID: 15030794 [PubMed - indexed for MEDLINE]Related articles

    11.

    Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors.

    Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, Ntambi JM.

    J Biol Chem. 2003 Sep 5;278(36):33904-11. Epub 2003 Jun 18.PMID: 12815040 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Stearoyl-CoA desaturase-1 and the metabolic syndrome.

    Cohen P, Ntambi JM, Friedman JM.

    Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):271-80. Review.PMID: 14683458 [PubMed - indexed for MEDLINE]Related articles

    13.

    Gene expression profiling in skeletal muscle of Zucker diabetic fatty rats: implications for a role of stearoyl-CoA desaturase 1 in insulin resistance.

    Voss MD, Beha A, Tennagels N, Tschank G, Herling AW, Quint M, Gerl M, Metz-Weidmann C, Haun G, Korn M.

    Diabetologia. 2005 Dec;48(12):2622-30. Epub 2005 Nov 12.PMID: 16284748 [PubMed - indexed for MEDLINE]Related articles

    14.

    Recent insights into stearoyl-CoA desaturase-1.

    Ntambi JM, Miyazaki M.

    Curr Opin Lipidol. 2003 Jun;14(3):255-61. Review.PMID: 12840656 [PubMed - indexed for MEDLINE]Related articles

    15.

    Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

    Jiang G, Li Z, Liu F, Ellsworth K, Dallas-Yang Q, Wu M, Ronan J, Esau C, Murphy C, Szalkowski D, Bergeron R, Doebber T, Zhang BB.

    J Clin Invest. 2005 Apr;115(4):1030-8. Epub 2005 Mar 10. Erratum in: J Clin Invest. 2005 Aug;115(8):2297. PMID: 15761499 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Stearoyl-coenzyme A desaturase 1 gene expression increases after pioglitazone treatment and is associated with peroxisomal proliferator-activated receptor-gamma responsiveness.

    Yao-Borengasser A, Rassouli N, Varma V, Bodles AM, Rasouli N, Unal R, Phanavanh B, Ranganathan G, McGehee RE Jr, Kern PA.

    J Clin Endocrinol Metab. 2008 Nov;93(11):4431-9. Epub 2008 Aug 12.PMID: 18697866 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.

    Xu H, Wilcox D, Nguyen P, Voorbach M, Smith H, Brodjian S, Suhar T, Reilly RM, Jacobson PB, Collins CA, Landschulz K, Surowy TK.

    Front Biosci. 2007 May 1;12:3781-94.PMID: 17485339 [PubMed - indexed for MEDLINE]Related articles

    18.

    Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.

    Matsusue K, Gavrilova O, Lambert G, Brewer HB Jr, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ.

    Mol Endocrinol. 2004 Nov;18(11):2751-64. Epub 2004 Aug 19.PMID: 15319454 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.

    Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS.

    Diabetes. 2006 Jul;55(7):1915-22.PMID: 16804058 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes.

    Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ.

    J Clin Invest. 2003 Mar;111(5):737-47.PMID: 12618528 [PubMed - indexed for MEDLINE]Related articlesFree article

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