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    Results: 1 to 20 of 65

    1.
    2.

    Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.

    Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H.

    Exp Neurol. 2008 Apr;210(2):409-20. Epub 2007 Dec 3.

    PMID:
    18164295
    [PubMed - indexed for MEDLINE]
    3.

    Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders?

    Windisch M, Wolf HJ, Hutter-Paier B, Hofmeister A, Wronski R.

    Curr Alzheimer Res. 2007 Sep;4(4):446-57. Review.

    PMID:
    17908049
    [PubMed - indexed for MEDLINE]
    4.

    Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

    Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R.

    J Neurosci. 2007 Apr 4;27(14):3639-49.

    PMID:
    17409228
    [PubMed - indexed for MEDLINE]
    Free Article
    5.

    Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients.

    Lashley T, Holton JL, Gray E, Kirkham K, O'Sullivan SS, Hilbig A, Wood NW, Lees AJ, Revesz T.

    Acta Neuropathol. 2008 Apr;115(4):417-25. Epub 2008 Jan 8.

    PMID:
    18185940
    [PubMed - indexed for MEDLINE]
    6.

    A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides.

    Gallardo G, Schlüter OM, Südhof TC.

    Nat Neurosci. 2008 Mar;11(3):301-8. Epub 2008 Feb 24.

    PMID:
    18297066
    [PubMed - indexed for MEDLINE]
    7.

    In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.

    Fodero-Tavoletti MT, Mulligan RS, Okamura N, Furumoto S, Rowe CC, Kudo Y, Masters CL, Cappai R, Yanai K, Villemagne VL.

    Eur J Pharmacol. 2009 Sep 1;617(1-3):54-8. Epub 2009 Jul 1.

    PMID:
    19576880
    [PubMed - indexed for MEDLINE]
    8.

    Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

    McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

    J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.

    PMID:
    17616527
    [PubMed - indexed for MEDLINE]
    Free Article
    9.

    Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease.

    Liu Y, Yoo MJ, Savonenko A, Stirling W, Price DL, Borchelt DR, Mamounas L, Lyons WE, Blue ME, Lee MK.

    J Neurosci. 2008 Dec 17;28(51):13805-14.

    PMID:
    19091971
    [PubMed - indexed for MEDLINE]
    Free Article
    10.

    Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease.

    Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG.

    Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1213-21. Epub 2009 Mar 7.

    PMID:
    19271231
    [PubMed - indexed for MEDLINE]
    11.

    Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases.

    Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E.

    PLoS One. 2008 Sep 4;3(9):e3135.

    PMID:
    18769546
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    12.

    Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.

    Halford RW, Russell DW.

    Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3502-6. Epub 2009 Feb 9.

    PMID:
    19204288
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    13.

    Transthyretin accelerates vascular Abeta deposition in a mouse model of Alzheimer's disease.

    Wati H, Kawarabayashi T, Matsubara E, Kasai A, Hirasawa T, Kubota T, Harigaya Y, Shoji M, Maeda S.

    Brain Pathol. 2009 Jan;19(1):48-57. Epub 2008 Apr 22.

    PMID:
    18429966
    [PubMed - indexed for MEDLINE]
    14.

    Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes.

    Hermann D, Both M, Ebert U, Gross G, Schoemaker H, Draguhn A, Wicke K, Nimmrich V.

    Neuroscience. 2009 Sep 15;162(4):1081-90. Epub 2009 May 27.

    PMID:
    19477243
    [PubMed - indexed for MEDLINE]
    15.

    Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level.

    Lippa SM, Lippa CF, Mori H.

    Am J Alzheimers Dis Other Demen. 2005 Sep-Oct;20(5):315-8.

    PMID:
    16273997
    [PubMed - indexed for MEDLINE]
    16.

    Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.

    Howlett DR, Bowler K, Soden PE, Riddell D, Davis JB, Richardson JC, Burbidge SA, Gonzalez MI, Irving EA, Lawman A, Miglio G, Dawson EL, Howlett ER, Hussain I.

    Histol Histopathol. 2008 Jan;23(1):67-76.

    PMID:
    17952859
    [PubMed - indexed for MEDLINE]
    17.

    Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.

    Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y.

    Brain Res. 2008 Jun 24;1216:92-103. Epub 2008 Apr 10.

    PMID:
    18486110
    [PubMed - indexed for MEDLINE]
    18.

    CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease.

    Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, El-Agnaf OM, Yamada M.

    Brain Res. 2009 Jan 28;1251:1-6. Epub 2008 Nov 28.

    PMID:
    19071095
    [PubMed - indexed for MEDLINE]
    19.

    Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

    Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T.

    J Neurosci. 2007 Nov 28;27(48):13092-7.

    PMID:
    18045903
    [PubMed - indexed for MEDLINE]
    Free Article
    20.

    In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

    Fodero-Tavoletti MT, Smith DP, McLean CA, Adlard PA, Barnham KJ, Foster LE, Leone L, Perez K, Cortés M, Culvenor JG, Li QX, Laughton KM, Rowe CC, Masters CL, Cappai R, Villemagne VL.

    J Neurosci. 2007 Sep 26;27(39):10365-71.

    PMID:
    17898208
    [PubMed - indexed for MEDLINE]
    Free Article

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