PubMed

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance.

del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO.

Diabetes. 2007 Jun;56(6):1638-46. Epub 2007 Mar 15.PMID: 17363744 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B.

J Biol Chem. 2005 Nov 11;280(45):37489-94. Epub 2005 Sep 8.PMID: 16166093 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes.

Takano A, Haruta T, Iwata M, Usui I, Uno T, Kawahara J, Ueno E, Sasaoka T, Kobayashi M.

Diabetes. 2001 Aug;50(8):1891-900.PMID: 11473053 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde AM, Kahn CR, Benito M.

Diabetes. 1999 Nov;48(11):2122-31.PMID: 10535444 [PubMed - indexed for MEDLINE]Related articlesFree article

Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of phosphatidylinositol 3-kinase and S6K1 kinase.

Adochio R, Leitner JW, Hedlund R, Draznin B.

Endocrinology. 2009 Mar;150(3):1165-73. Epub 2008 Oct 23.PMID: 18948408 [PubMed - indexed for MEDLINE]Related articles

Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

Arribas M, Valverde AM, Benito M.

J Biol Chem. 2003 Nov 14;278(46):45189-99. Epub 2003 Aug 27.PMID: 12944402 [PubMed - indexed for MEDLINE]Related articlesFree article

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.

Ueki K, Algenstaedt P, Mauvais-Jarvis F, Kahn CR.

Mol Cell Biol. 2000 Nov;20(21):8035-46.PMID: 11027274 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase.

Terauchi Y, Matsui J, Kamon J, Yamauchi T, Kubota N, Komeda K, Aizawa S, Akanuma Y, Tomita M, Kadowaki T.

Diabetes. 2004 Sep;53(9):2261-70.PMID: 15331535 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling.

Johansen T, Laurino C, Barreca A, Malmlöf K.

Growth Horm IGF Res. 2005 Feb;15(1):55-63. Epub 2005 Jan 22.PMID: 15701573 [PubMed - indexed for MEDLINE]Related articles

Loss of sensitivity to insulin at early events of the insulin signaling pathway in the liver of growth hormone-transgenic mice.

Dominici FP, Cifone D, Bartke A, Turyn D.

J Endocrinol. 1999 Jun;161(3):383-92.PMID: 10333541 [PubMed - indexed for MEDLINE]Related articlesFree article

Body composition of inactivated growth hormone (oMt1a-oGH) transgenic mice: generation of an obese phenotype.

Oberbauer AM, Stern JS, Johnson PR, Horwitz BA, German JB, Phinney SD, Beermann DH, Pomp D, Murray JD.

Growth Dev Aging. 1997 Fall-Winter;61(3-4):169-79.PMID: 9546108 [PubMed - indexed for MEDLINE]Related articles

Evidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion.

Jessen N, Djurhuus CB, Jørgensen JO, Jensen LS, Møller N, Lund S, Schmitz O.

Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E194-9. Epub 2004 Aug 31.PMID: 15339744 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients.

Lefai E, Roques M, Vega N, Laville M, Vidal H.

Biochem J. 2001 Nov 15;360(Pt 1):117-26.PMID: 11695998 [PubMed - indexed for MEDLINE]Related articlesFree article

The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes.

Rieusset J, Chambrier C, Bouzakri K, Dusserre E, Auwerx J, Riou JP, Laville M, Vidal H.

Diabetologia. 2001 May;44(5):544-54.PMID: 11380072 [PubMed - indexed for MEDLINE]Related articles

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR.

J Clin Invest. 2002 Jan;109(1):141-9.PMID: 11781359 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine.

de Castro Barbosa T, de Carvalho JE, Poyares LL, Bordin S, Machado UF, Nunes MT.

Endocrinology. 2009 May;150(5):2080-6. Epub 2008 Dec 23.PMID: 19106217 [PubMed - indexed for MEDLINE]Related articles

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.

Deng Y, Bhattacharya S, Swamy OR, Tandon R, Wang Y, Janda R, Riedel H.

J Biol Chem. 2003 Oct 10;278(41):39311-22. Epub 2003 Jun 3.PMID: 12783867 [PubMed - indexed for MEDLINE]Related articlesFree article

Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.

Tsuji Y, Kaburagi Y, Terauchi Y, Satoh S, Kubota N, Tamemoto H, Kraemer FB, Sekihara H, Aizawa S, Akanuma Y, Tobe K, Kimura S, Kadowaki T.

Diabetes. 2001 Jun;50(6):1455-63.PMID: 11375348 [PubMed - indexed for MEDLINE]Related articlesFree article

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.

Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y.

Nat Med. 2002 Jul;8(7):731-7. Epub 2002 Jun 17.PMID: 12068289 [PubMed - indexed for MEDLINE]Related articles

Expression of insulin target genes in skeletal muscle and adipose tissue in adult patients with growth hormone deficiency: effect of one year recombinant human growth hormone therapy.

Khalfallah Y, Sassolas G, Borson-Chazot F, Vega N, Vidal H.

J Endocrinol. 2001 Nov;171(2):285-92.PMID: 11691648 [PubMed - indexed for MEDLINE]Related articlesFree article