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    Results: 1 to 20 of 196

    1.

    Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.

    Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S.

    Diabetes. 2007 Jun;56(6):1551-8. Epub 2007 Mar 14.PMID: 17360984 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.

    Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA.

    Diabetes. 2001 May;50(5):1004-11.PMID: 11334402 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.

    Hansotia T, Drucker DJ.

    Regul Pept. 2005 Jun 15;128(2):125-34. Review.PMID: 15780432 [PubMed - indexed for MEDLINE]Related articles

    4.

    Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

    Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K.

    Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21.PMID: 19386626 [PubMed - indexed for MEDLINE]Related articles

    5.

    The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.

    Vilsbøll T, Knop FK, Krarup T, Johansen A, Madsbad S, Larsen S, Hansen T, Pedersen O, Holst JJ.

    J Clin Endocrinol Metab. 2003 Oct;88(10):4897-903.PMID: 14557471 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

    Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

    Diabetes. 2001 Feb;50(2):308-14.PMID: 11272141 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    The incretin hormones GIP and GLP-1 in diabetic rats: effects on insulin secretion and small bowel motility.

    Edholm T, Cejvan K, Abdel-Halim SM, Efendic S, Schmidt PT, Hellström PM.

    Neurogastroenterol Motil. 2009 Mar;21(3):313-21. Epub 2008 Dec 18.PMID: 19126188 [PubMed - indexed for MEDLINE]Related articles

    8.

    Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.

    Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA.

    Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. Epub 2003 Jan 21.PMID: 12540373 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight.

    Schou JH, Pilgaard K, Vilsbøll T, Jensen CB, Deacon CF, Holst JJ, Vølund A, Madsbad S, Vaag AA.

    J Clin Endocrinol Metab. 2005 Aug;90(8):4912-9. Epub 2005 May 17.PMID: 15899957 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

    Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F, Drucker DJ.

    Diabetes. 2004 May;53(5):1326-35.PMID: 15111503 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.

    Preitner F, Ibberson M, Franklin I, Binnert C, Pende M, Gjinovci A, Hansotia T, Drucker DJ, Wollheim C, Burcelin R, Thorens B.

    J Clin Invest. 2004 Feb;113(4):635-45.PMID: 14966573 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.

    Almind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ, Gromada J, Thorens B, Pedersen O.

    Diabetologia. 1998 Oct;41(10):1194-8.PMID: 9794107 [PubMed - indexed for MEDLINE]Related articles

    13.

    Glucagon receptors on human islet cells contribute to glucose competence of insulin release.

    Huypens P, Ling Z, Pipeleers D, Schuit F.

    Diabetologia. 2000 Aug;43(8):1012-9.PMID: 10990079 [PubMed - indexed for MEDLINE]Related articles

    14.

    Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets.

    Zhou J, Livak MF, Bernier M, Muller DC, Carlson OD, Elahi D, Maudsley S, Egan JM.

    Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E538-47. Epub 2007 May 15.PMID: 17505054 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells.

    Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA.

    FASEB J. 2003 Jan;17(1):91-3. Epub 2002 Nov 15.PMID: 12475913 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells.

    Nakagawa A, Satake H, Nakabayashi H, Nishizawa M, Furuya K, Nakano S, Kigoshi T, Nakayama K, Uchida K.

    Auton Neurosci. 2004 Jan 30;110(1):36-43.PMID: 14766323 [PubMed - indexed for MEDLINE]Related articles

    17.

    Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats.

    Tseng CC, Boylan MO, Jarboe LA, Usdin TB, Wolfe MM.

    Am J Physiol. 1996 Apr;270(4 Pt 1):E661-6.PMID: 8928774 [PubMed - indexed for MEDLINE]Related articles

    18.

    Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas.

    Heller RS, Kieffer TJ, Habener JF.

    Diabetes. 1997 May;46(5):785-91.PMID: 9133545 [PubMed - indexed for MEDLINE]Related articles

    19.

    Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans.

    Holst JJ, Gromada J.

    Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206. Review.PMID: 15271645 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Differential Importance of GIP Versus GLP-1 Receptor Signaling for Beta Cell Survival in Mice.

    Maida A, Hansotia T, Longuet C, Seino Y, Drucker DJ.

    Gastroenterology. 2009 Sep 17. [Epub ahead of print]PMID: 19766644 [PubMed - as supplied by publisher]Related articles

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