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    Results: 1 to 20 of 407

    1.

    Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice.

    Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC.

    Diabetes. 2007 May;56(5):1324-32. Epub 2007 Mar 12.PMID: 17353506 [PubMed - indexed for MEDLINE]Related articlesFree article

    2.

    Islet amyloid polypeptide (IAPP) transgenic rodents as models for type 2 diabetes.

    Matveyenko AV, Butler PC.

    ILAR J. 2006;47(3):225-33. Review.PMID: 16804197 [PubMed - indexed for MEDLINE]Related articlesFree article

    3.

    Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

    Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC.

    Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1317-24. Epub 2006 Jul 18.PMID: 16849627 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.

    Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC.

    Diabetes. 2004 Jun;53(6):1509-16.PMID: 15161755 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide.

    Huang CJ, Haataja L, Gurlo T, Butler AE, Wu X, Soeller WC, Butler PC.

    Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1656-62. Epub 2007 Oct 2.PMID: 17911343 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

    Butler AE, Janson J, Soeller WC, Butler PC.

    Diabetes. 2003 Sep;52(9):2304-14.PMID: 12941770 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.

    Paulsson JF, Andersson A, Westermark P, Westermark GT.

    Diabetologia. 2006 Jun;49(6):1237-46. Epub 2006 Mar 29.PMID: 16570161 [PubMed - indexed for MEDLINE]Related articles

    8.

    High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes.

    Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA, Butler PC.

    Diabetes. 2007 Aug;56(8):2016-27. Epub 2007 May 2.PMID: 17475933 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis.

    Ritzel RA, Butler PC.

    Diabetes. 2003 Jul;52(7):1701-8.PMID: 12829636 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.

    Matveyenko AV, Gurlo T, Daval M, Butler AE, Butler PC.

    Diabetes. 2009 Apr;58(4):906-16. Epub 2009 Jan 16.PMID: 19151199 [PubMed - indexed for MEDLINE]Related articlesFree article

    11.

    Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

    Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC.

    J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. Epub 2005 Oct 4.PMID: 16204373 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

    Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC.

    Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7283-8.PMID: 8692984 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets.

    Udayasankar J, Kodama K, Hull RL, Zraika S, Aston-Mourney K, Subramanian SL, Tong J, Faulenbach MV, Vidal J, Kahn SE.

    Diabetologia. 2009 Jan;52(1):145-53. Epub 2008 Nov 11.PMID: 19002432 [PubMed - indexed for MEDLINE]Related articles

    14.

    Amyloid formation in response to beta cell stress occurs in vitro, but not in vivo, in islets of transgenic mice expressing human islet amyloid polypeptide.

    Westermark G, Arora MB, Fox N, Carroll R, Chan SJ, Westermark P, Steiner DF.

    Mol Med. 1995 Jul;1(5):542-53.PMID: 8529120 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

    Yagui K, Yamaguchi T, Kanatsuka A, Shimada F, Huang CI, Tokuyama Y, Ohsawa H, Yamamura K, Miyazaki J, Mikata A, et al.

    Eur J Endocrinol. 1995 Apr;132(4):487-96.PMID: 7711888 [PubMed - indexed for MEDLINE]Related articles

    16.

    Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

    Haataja L, Gurlo T, Huang CJ, Butler PC.

    Endocr Rev. 2008 May;29(3):303-16. Epub 2008 Feb 26. Review.PMID: 18314421 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

    Jaikaran ET, Clark A.

    Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203. Review.PMID: 11731221 [PubMed - indexed for MEDLINE]Related articles

    18.

    Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model.

    Höppener JW, Oosterwijk C, Nieuwenhuis MG, Posthuma G, Thijssen JH, Vroom TM, Ahrén B, Lips CJ.

    Diabetologia. 1999 Apr;42(4):427-34.PMID: 10230646 [PubMed - indexed for MEDLINE]Related articles

    19.

    beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

    Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE.

    Diabetes. 2000 Dec;49(12):2056-62.PMID: 11118007 [PubMed - indexed for MEDLINE]Related articlesFree article

    20.

    Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

    Matveyenko AV, Butler PC.

    Diabetes. 2006 Jul;55(7):2106-14.PMID: 16804082 [PubMed - indexed for MEDLINE]Related articlesFree article

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